Sex-Specific Ventricular Arrhythmias and Mortality in Cardiac Resynchronization Therapy Recipients

OBJECTIVES The study goal was to examine whether there are sex-related differences in the incidence of ventricular arrhythmias and mortality in CRT-defibrillator (CRT-D) recipients. BACKGROUND Few studies have evaluated sex-related benefits of cardiac resynchronization therapy (CRT). Moreover, data...

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Autores: Quesada, A, Arteaga, F, Romero-Villafranca, R, Perez-Alvarez, L, Martinez-Ferrer, J, Alzueta-Rodriguez, J, de la Concha, JF, Martinez, JG, Vinolas, X, Porres, JM, Anguera, I, Porro-Fernandez, R, Quesada-Ocete, B, de la Guia-Galipienso, F, Palanca, V, Jimenez, J, Quesada-Ocete, J, Sanchis-Gomar, F, UMBRELLA Res Grp
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p4662
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4662
Access Level:acceso abierto
Palabra clave:cardiac resynchronization therapy
heart failure
mortality
sex
ventricular tachyarrhythmia
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spelling Sex-Specific Ventricular Arrhythmias and Mortality in Cardiac Resynchronization Therapy RecipientsQuesada, AArteaga, FRomero-Villafranca, RPerez-Alvarez, LMartinez-Ferrer, JAlzueta-Rodriguez, Jde la Concha, JFMartinez, JGVinolas, XPorres, JMAnguera, IPorro-Fernandez, RQuesada-Ocete, Bde la Guia-Galipienso, FPalanca, VJimenez, JQuesada-Ocete, JSanchis-Gomar, FUMBRELLA Res Grpcardiac resynchronization therapyheart failuremortalitysexventricular tachyarrhythmiaOBJECTIVES The study goal was to examine whether there are sex-related differences in the incidence of ventricular arrhythmias and mortality in CRT-defibrillator (CRT-D) recipients. BACKGROUND Few studies have evaluated sex-related benefits of cardiac resynchronization therapy (CRT). Moreover, data on sex-related differences in the occurrence of ventricular tachyarrhythmias in this population are limited. METHODS A multicenter retrospective study was conducted in 460 patients (355 male subjects and 105 female subjects) from the UMBRELLA (Incidence of Arrhythmia in Spanish Population With a Medtronic Implantable Cardiac Defibrillator Implant) national registry. Patients were followed up through remote monitoring after the first implantation of a CRT-D during a median follow-up of 2.2 +/- 1.0 years. Sex differences were analyzed in terms of ventricular arrhythmia-treated incidence and death during the follow-up period, with a particular focus on primary prevention patients. RESULTS Baseline New York Heart Association functional class was worse in women compared with that in men (67.0% of women in New York Heart Association functional class III vs. 49.7% of men; p = 0.003), whereas women had less ischemic cardiac disease (20.8% vs. 41.7%; p < 0.001). Female sex was an independent predictor of ventricular arrhythmias (hazard ratio: 0.40; 95% confidence interval: 0.19 to 0.86; p = 0.020), as well as left ventricular ejection fraction and nonischemic cardiomyopathy. Mortality in women was one-half that of men, although events were scarce and without significant differences (2.9% vs. 5.6%; p = 0.25). CONCLUSIONS Women with left bundle branch block and implanted CRT have a lower rate of ventricular tachyarrhythmias than men. All-cause mortality in patients is, at least, similar between female and male subjects. (C) 2021 by the American College of Cardiology Foundation.ELSEVIER2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4662JACC-Clinical ElectrophysiologyISSN: 2405500XISSNe: 24055018reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p46622026-06-14T12:41:47Z
dc.title.none.fl_str_mv Sex-Specific Ventricular Arrhythmias and Mortality in Cardiac Resynchronization Therapy Recipients
title Sex-Specific Ventricular Arrhythmias and Mortality in Cardiac Resynchronization Therapy Recipients
spellingShingle Sex-Specific Ventricular Arrhythmias and Mortality in Cardiac Resynchronization Therapy Recipients
Quesada, A
cardiac resynchronization therapy
heart failure
mortality
sex
ventricular tachyarrhythmia
title_short Sex-Specific Ventricular Arrhythmias and Mortality in Cardiac Resynchronization Therapy Recipients
title_full Sex-Specific Ventricular Arrhythmias and Mortality in Cardiac Resynchronization Therapy Recipients
title_fullStr Sex-Specific Ventricular Arrhythmias and Mortality in Cardiac Resynchronization Therapy Recipients
title_full_unstemmed Sex-Specific Ventricular Arrhythmias and Mortality in Cardiac Resynchronization Therapy Recipients
title_sort Sex-Specific Ventricular Arrhythmias and Mortality in Cardiac Resynchronization Therapy Recipients
dc.creator.none.fl_str_mv Quesada, A
Arteaga, F
Romero-Villafranca, R
Perez-Alvarez, L
Martinez-Ferrer, J
Alzueta-Rodriguez, J
de la Concha, JF
Martinez, JG
Vinolas, X
Porres, JM
Anguera, I
Porro-Fernandez, R
Quesada-Ocete, B
de la Guia-Galipienso, F
Palanca, V
Jimenez, J
Quesada-Ocete, J
Sanchis-Gomar, F
UMBRELLA Res Grp
author Quesada, A
author_facet Quesada, A
Arteaga, F
Romero-Villafranca, R
Perez-Alvarez, L
Martinez-Ferrer, J
Alzueta-Rodriguez, J
de la Concha, JF
Martinez, JG
Vinolas, X
Porres, JM
Anguera, I
Porro-Fernandez, R
Quesada-Ocete, B
de la Guia-Galipienso, F
Palanca, V
Jimenez, J
Quesada-Ocete, J
Sanchis-Gomar, F
UMBRELLA Res Grp
author_role author
author2 Arteaga, F
Romero-Villafranca, R
Perez-Alvarez, L
Martinez-Ferrer, J
Alzueta-Rodriguez, J
de la Concha, JF
Martinez, JG
Vinolas, X
Porres, JM
Anguera, I
Porro-Fernandez, R
Quesada-Ocete, B
de la Guia-Galipienso, F
Palanca, V
Jimenez, J
Quesada-Ocete, J
Sanchis-Gomar, F
UMBRELLA Res Grp
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv cardiac resynchronization therapy
heart failure
mortality
sex
ventricular tachyarrhythmia
topic cardiac resynchronization therapy
heart failure
mortality
sex
ventricular tachyarrhythmia
description OBJECTIVES The study goal was to examine whether there are sex-related differences in the incidence of ventricular arrhythmias and mortality in CRT-defibrillator (CRT-D) recipients. BACKGROUND Few studies have evaluated sex-related benefits of cardiac resynchronization therapy (CRT). Moreover, data on sex-related differences in the occurrence of ventricular tachyarrhythmias in this population are limited. METHODS A multicenter retrospective study was conducted in 460 patients (355 male subjects and 105 female subjects) from the UMBRELLA (Incidence of Arrhythmia in Spanish Population With a Medtronic Implantable Cardiac Defibrillator Implant) national registry. Patients were followed up through remote monitoring after the first implantation of a CRT-D during a median follow-up of 2.2 +/- 1.0 years. Sex differences were analyzed in terms of ventricular arrhythmia-treated incidence and death during the follow-up period, with a particular focus on primary prevention patients. RESULTS Baseline New York Heart Association functional class was worse in women compared with that in men (67.0% of women in New York Heart Association functional class III vs. 49.7% of men; p = 0.003), whereas women had less ischemic cardiac disease (20.8% vs. 41.7%; p < 0.001). Female sex was an independent predictor of ventricular arrhythmias (hazard ratio: 0.40; 95% confidence interval: 0.19 to 0.86; p = 0.020), as well as left ventricular ejection fraction and nonischemic cardiomyopathy. Mortality in women was one-half that of men, although events were scarce and without significant differences (2.9% vs. 5.6%; p = 0.25). CONCLUSIONS Women with left bundle branch block and implanted CRT have a lower rate of ventricular tachyarrhythmias than men. All-cause mortality in patients is, at least, similar between female and male subjects. (C) 2021 by the American College of Cardiology Foundation.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4662
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4662
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ELSEVIER
publisher.none.fl_str_mv ELSEVIER
dc.source.none.fl_str_mv JACC-Clinical Electrophysiology
ISSN: 2405500X
ISSNe: 24055018
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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