Sex-Specific Ventricular Arrhythmias and Mortality in Cardiac Resynchronization Therapy Recipients

OBJECTIVES The study goal was to examine whether there are sex-related differences in the incidence of ventricular arrhythmias and mortality in CRT-defibrillator (CRT-D) recipients. BACKGROUND Few studies have evaluated sex-related benefits of cardiac resynchronization therapy (CRT). Moreover, data...

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Detalles Bibliográficos
Autores: Quesada Dorador, Aurelio, Arteaga Moreno, Francisco Javier, Romero Villafranca, Rafael, Pérez Álvarez, Luisa, Martínez Ferrer, José, Alzueta Rodríguez, Javier, Fernández de la Concha, Joaquín, Martínez, Juan G., Viñolas, Xavier, Porres, José M., Anguera, Ignasi, Porro Fernández, Rosa, Quesada Ocete, Blanca, de la Guía Galipienso, Fernando, Palanca Gil, Víctor, Jiménez, Javier, Quesada Ocete, Francisco Javier, Sanchis Gomar, Fabian
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad Católica de Valencia San Vicente Mártir
Repositorio:RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
Idioma:inglés
OAI Identifier:oai:riucv.ucv.es:20.500.12466/3953
Acceso en línea:http://hdl.handle.net/20.500.12466/3953
Access Level:acceso abierto
Palabra clave:Cardiac resynchronization therapy
Heart failure
Mortality
Sex
Ventricular tachyarrhythmia
3205.01 Cardiología
Descripción
Sumario:OBJECTIVES The study goal was to examine whether there are sex-related differences in the incidence of ventricular arrhythmias and mortality in CRT-defibrillator (CRT-D) recipients. BACKGROUND Few studies have evaluated sex-related benefits of cardiac resynchronization therapy (CRT). Moreover, data on sex-related differences in the occurrence of ventricular tachyarrhythmias in this population are limited. METHODS A multicenter retrospective study was conducted in 460 patients (355 male subjects and 105 female sub- jects) from the UMBRELLA (Incidence of Arrhythmia in Spanish Population With a Medtronic Implantable Cardiac Defi- brillator Implant) national registry. Patients were followed up through remote monitoring after the first implantation of a CRT-D during a median follow-up of 2.2 1.0 years. Sex differences were analyzed in terms of ventricular arrhythmia– treated incidence and death during the follow-up period, with a particular focus on primary prevention patients. RESULTS Baseline New York Heart Association functional class was worse in women compared with that in men (67.0% of women in New York Heart Association functional class III vs. 49.7% of men; p ¼ 0.003), whereas women had less ischemic cardiac disease (20.8% vs. 41.7%; p < 0.001). Female sex was an independent predictor of ventricular ar- rhythmias (hazard ratio: 0.40; 95% confidence interval: 0.19 to 0.86; p ¼ 0.020), as well as left ventricular ejection fraction and nonischemic cardiomyopathy. Mortality in women was one-half that of men, although events were scarce and without significant differences (2.9% vs. 5.6%; p ¼ 0.25). CONCLUSIONS Women with left bundle branch block and implanted CRT have a lower rate of ventricular tachyarrhythmias than men. All-cause mortality in patients is, at least, similar between female and male subjects.

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