Cerebral changes and disrupted gray-matter cortical networks in asymptomatic older adults at risk for Alzheimer's disease

The diagnostic value of cerebrospinal fluid (CSF) biomarkers is well established in Alzheimer's disease, but our current knowledge about how abnormal CSF levels affect cerebral integrity, at local and network levels, is incomplete in asymptomatic older adults. Here, we have collected CSF sample...

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Autores: Cantero, José L., Atienza, Mercedes, Sánchez-Juan, Pascual|||0000-0002-6081-8037, Rodríguez Rodríguez, Eloy Manuel, Vázquez Higuera, José Luis, Pozueta Cantudo, Ana, González Suárez, Andrea, Vilaplana, Eduard, Pegueroles, Jordi, Montal, Víctor, Blesa, Rafael, Alcolea, Daniel, Lleo, Alberto, Fortea, Juan
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universidad de Cantabria (UC)
Repositorio:UCrea Repositorio Abierto de la Universidad de Cantabria
Idioma:inglés
OAI Identifier:oai:repositorio.unican.es:10902/12928
Acceso en línea:http://hdl.handle.net/10902/12928
Access Level:acceso abierto
Palabra clave:Preclinical Alzheimer's disease
SNAP
CSF biomarkers
Cortical thickness
Structural cortical networks
White matter
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spelling Cerebral changes and disrupted gray-matter cortical networks in asymptomatic older adults at risk for Alzheimer's diseaseCantero, José L.Atienza, MercedesSánchez-Juan, Pascual|||0000-0002-6081-8037Rodríguez Rodríguez, Eloy ManuelVázquez Higuera, José LuisPozueta Cantudo, AnaGonzález Suárez, AndreaVilaplana, EduardPegueroles, JordiMontal, VíctorBlesa, RafaelAlcolea, DanielLleo, AlbertoFortea, JuanPreclinical Alzheimer's diseaseSNAPCSF biomarkersCortical thicknessStructural cortical networksWhite matterThe diagnostic value of cerebrospinal fluid (CSF) biomarkers is well established in Alzheimer's disease, but our current knowledge about how abnormal CSF levels affect cerebral integrity, at local and network levels, is incomplete in asymptomatic older adults. Here, we have collected CSF samples and performed structural magnetic resonance imaging scans in cognitively normal elderly as part of a cross-sectional multicenter study (SIGNAL project). To identify group differences in cortical thickness, white matter volume, and properties of structural networks, participants were split into controls (N = 20), positive amyloid-? (A?1?42 +) (N = 19), and positive phosphorylated tau (N = 18). The A?1?42 + group exhibited thickening of middle temporal regions, while positive phosphorylated tau individuals showed thinning in the superior parietal and orbitofrontal cortices. Subjects with abnormal CSF biomarkers further showed regional white matter atrophy and more segregated cortical networks, the A?1?42 + group showing heightened isolation of cingulate and temporal cortices. Collectively, these findings highlight the relevance of combining structural brain imaging and connectomics for in vivo tracking of Alzheimer's disease lesions in asymptomatic stages.This work was supported by research grants from the Spanish Ministry of Economy and Competitiveness (SAF2011-25463 to J.L.C., PSI2014-55747-R to M.A.), the Carlos III Institute of Health, Spain (PI11/02425 and PI14/01126 to J.F.; PI11/3035 and PI14/1561 to A.L.; PI08/0139, PI12/02288 and PI16/01652 to P.S.J.), jointly funded by Fondo Europeo de Desarrollo Regional (FEDER), Unión Europea, “Una manera de hacer Europa”, the Joint Programming in Neurodegenerative Disease Research (DEMTEST to P.S.J.), “Marató TV3” (project 20141210 to J.F. and 20142610 to A.L.), the Regional Ministry of Innovation, Science and Enterprise, Junta de Andalucia (P12- CTS-2327 to J.C.L.), and the CIBERNED program (Signal project).ElsevierUniversidad de Cantabria20182018-04-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttp://hdl.handle.net/10902/12928Neurobiology of Aging Volume 64, April 2018, Pages 58-67reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/129282026-06-02T12:39:31Z
dc.title.none.fl_str_mv Cerebral changes and disrupted gray-matter cortical networks in asymptomatic older adults at risk for Alzheimer's disease
title Cerebral changes and disrupted gray-matter cortical networks in asymptomatic older adults at risk for Alzheimer's disease
spellingShingle Cerebral changes and disrupted gray-matter cortical networks in asymptomatic older adults at risk for Alzheimer's disease
Cantero, José L.
Preclinical Alzheimer's disease
SNAP
CSF biomarkers
Cortical thickness
Structural cortical networks
White matter
title_short Cerebral changes and disrupted gray-matter cortical networks in asymptomatic older adults at risk for Alzheimer's disease
title_full Cerebral changes and disrupted gray-matter cortical networks in asymptomatic older adults at risk for Alzheimer's disease
title_fullStr Cerebral changes and disrupted gray-matter cortical networks in asymptomatic older adults at risk for Alzheimer's disease
title_full_unstemmed Cerebral changes and disrupted gray-matter cortical networks in asymptomatic older adults at risk for Alzheimer's disease
title_sort Cerebral changes and disrupted gray-matter cortical networks in asymptomatic older adults at risk for Alzheimer's disease
dc.creator.none.fl_str_mv Cantero, José L.
Atienza, Mercedes
Sánchez-Juan, Pascual|||0000-0002-6081-8037
Rodríguez Rodríguez, Eloy Manuel
Vázquez Higuera, José Luis
Pozueta Cantudo, Ana
González Suárez, Andrea
Vilaplana, Eduard
Pegueroles, Jordi
Montal, Víctor
Blesa, Rafael
Alcolea, Daniel
Lleo, Alberto
Fortea, Juan
author Cantero, José L.
author_facet Cantero, José L.
Atienza, Mercedes
Sánchez-Juan, Pascual|||0000-0002-6081-8037
Rodríguez Rodríguez, Eloy Manuel
Vázquez Higuera, José Luis
Pozueta Cantudo, Ana
González Suárez, Andrea
Vilaplana, Eduard
Pegueroles, Jordi
Montal, Víctor
Blesa, Rafael
Alcolea, Daniel
Lleo, Alberto
Fortea, Juan
author_role author
author2 Atienza, Mercedes
Sánchez-Juan, Pascual|||0000-0002-6081-8037
Rodríguez Rodríguez, Eloy Manuel
Vázquez Higuera, José Luis
Pozueta Cantudo, Ana
González Suárez, Andrea
Vilaplana, Eduard
Pegueroles, Jordi
Montal, Víctor
Blesa, Rafael
Alcolea, Daniel
Lleo, Alberto
Fortea, Juan
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad de Cantabria
dc.subject.none.fl_str_mv Preclinical Alzheimer's disease
SNAP
CSF biomarkers
Cortical thickness
Structural cortical networks
White matter
topic Preclinical Alzheimer's disease
SNAP
CSF biomarkers
Cortical thickness
Structural cortical networks
White matter
description The diagnostic value of cerebrospinal fluid (CSF) biomarkers is well established in Alzheimer's disease, but our current knowledge about how abnormal CSF levels affect cerebral integrity, at local and network levels, is incomplete in asymptomatic older adults. Here, we have collected CSF samples and performed structural magnetic resonance imaging scans in cognitively normal elderly as part of a cross-sectional multicenter study (SIGNAL project). To identify group differences in cortical thickness, white matter volume, and properties of structural networks, participants were split into controls (N = 20), positive amyloid-? (A?1?42 +) (N = 19), and positive phosphorylated tau (N = 18). The A?1?42 + group exhibited thickening of middle temporal regions, while positive phosphorylated tau individuals showed thinning in the superior parietal and orbitofrontal cortices. Subjects with abnormal CSF biomarkers further showed regional white matter atrophy and more segregated cortical networks, the A?1?42 + group showing heightened isolation of cingulate and temporal cortices. Collectively, these findings highlight the relevance of combining structural brain imaging and connectomics for in vivo tracking of Alzheimer's disease lesions in asymptomatic stages.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-04-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10902/12928
url http://hdl.handle.net/10902/12928
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Neurobiology of Aging Volume 64, April 2018, Pages 58-67
reponame:UCrea Repositorio Abierto de la Universidad de Cantabria
instname:Universidad de Cantabria (UC)
instname_str Universidad de Cantabria (UC)
reponame_str UCrea Repositorio Abierto de la Universidad de Cantabria
collection UCrea Repositorio Abierto de la Universidad de Cantabria
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300724

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