Longitudinal association of shorter leukocyte telomere length with CSF biomarker dynamics across early Alzheimer's disease stages in at-risk individuals

Short telomere length (TL), a hallmark of biological ageing, has been associated with an increased risk of Alzheimer's disease (AD), but its pathophysiological role remains unclear. This study explored the relationship between blood leukocyte TL (LTL), cerebrospinal fluid (CSF) AD biomarkers ch...

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Detalhes bibliográficos
Autores: Rodríguez-Fernández, Blanca, González-Escalante, Armand, Genius, Patricia, Evans, Tavia E., Ortiz-Romero, Paula, Minguillón, Carolina, Kollmorgen, Gwendlyn, Ashton, Nicholas J, Zetterberg, Henrik, Blennow, Kaj, Gispert, Juan Domingo, Navarro, Arcadi, Suárez-Calvet, Marc, Sala-Vila, Aleix, Crous-Bou, Marta, Vilor-Tejedor, Natàlia, ALFA study
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2025
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositório:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:dnet:digitalcsic_::8a346439b8273751655e2e63ae74e253
Acesso em linha:http://hdl.handle.net/10261/426885
https://api.elsevier.com/content/abstract/scopus_id/105013242962
Access Level:Acceso aberto
Palavra-chave:Alzheimer's disease
Cortical thickness
Glial biomarkers
Leukocyte telomere length
Preclinical
Descrição
Resumo:Short telomere length (TL), a hallmark of biological ageing, has been associated with an increased risk of Alzheimer's disease (AD), but its pathophysiological role remains unclear. This study explored the relationship between blood leukocyte TL (LTL), cerebrospinal fluid (CSF) AD biomarkers changes, and brain structure across early stages of the AD continuum.

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