The novel MFS efflux pump SxtP, regulated by the LysR-type transcriptional activator SxtR, is involved in the susceptibility to sulfamethoxazole/trimethoprim (SXT) and the pathogenesis of Acinetobacter baumannii

Acinetobacter baumannii is a notorious opportunistic pathogen responsible for healthcare-associated infections worldwide. Efflux pumps play crucial roles in mediating antimicrobial resistance, motility, and virulence. In this study, we present the identification and characterization of the new A. ba...

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Detalles Bibliográficos
Autores: Gaona Soler, Marc, Corral, Jordi|||0000-0003-2047-6156, Campoy Sánchez, Susana|||0000-0003-1369-0197, Barbé García, Jordi|||0000-0003-4408-013X, Pérez-Varela, María|||0000-0003-0990-4041, Aranda Rodríguez, Jesús|||0000-0002-1135-095X
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:311233
Acceso en línea:https://ddd.uab.cat/record/311233
https://dx.doi.org/urn:doi:10.1128/aac.00712-24
Access Level:acceso abierto
Palabra clave:Acinetobacter
MFS efflux pump
LysR-type transcriptional regulator
Co-trimoxazole
Descripción
Sumario:Acinetobacter baumannii is a notorious opportunistic pathogen responsible for healthcare-associated infections worldwide. Efflux pumps play crucial roles in mediating antimicrobial resistance, motility, and virulence. In this study, we present the identification and characterization of the new A. baumannii efflux pump SxtP belonging to the MFS superfamily (major facilitator superfamily), along with its associated activator LysR-type transcriptional regulator (LTTR) SxtR, demonstrating their roles in sulfamethoxazole/trimethoprim (also known as co-trimoxazole or SXT) resistance, surface-associated motility and virulence.

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