The novel MFS efflux pump SxtP, regulated by the LysR-type transcriptional activator SxtR, is involved in the susceptibility to sulfamethoxazole/trimethoprim (SXT) and the pathogenesis of Acinetobacter baumannii

Acinetobacter baumannii is a notorious opportunistic pathogen responsible for healthcare-associated infections worldwide. Efflux pumps play crucial roles in mediating antimicrobial resistance, motility, and virulence. In this study, we present the identification and characterization of the new A. ba...

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Authors: Gaona Soler, Marc, Corral, Jordi|||0000-0003-2047-6156, Campoy Sánchez, Susana|||0000-0003-1369-0197, Barbé García, Jordi|||0000-0003-4408-013X, Pérez-Varela, María|||0000-0003-0990-4041, Aranda Rodríguez, Jesús|||0000-0002-1135-095X
Format: article
Publication Date:2024
Country:España
Institution:Universitat Autònoma de Barcelona
Repository:Dipòsit Digital de Documents de la UAB
Language:English
OAI Identifier:oai:ddd.uab.cat:311233
Online Access:https://ddd.uab.cat/record/311233
https://dx.doi.org/urn:doi:10.1128/aac.00712-24
Access Level:Open access
Keyword:Acinetobacter
MFS efflux pump
LysR-type transcriptional regulator
Co-trimoxazole
Description
Summary:Acinetobacter baumannii is a notorious opportunistic pathogen responsible for healthcare-associated infections worldwide. Efflux pumps play crucial roles in mediating antimicrobial resistance, motility, and virulence. In this study, we present the identification and characterization of the new A. baumannii efflux pump SxtP belonging to the MFS superfamily (major facilitator superfamily), along with its associated activator LysR-type transcriptional regulator (LTTR) SxtR, demonstrating their roles in sulfamethoxazole/trimethoprim (also known as co-trimoxazole or SXT) resistance, surface-associated motility and virulence.

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