Adverse prognostic impact of complex karyotype (≥3 cytogenetic alterations) in adult T-cell acute lymphoblastic leukemia (T-ALL)

The potential prognostic value of conventional karyotyping in adult T-cell acute lymphoblastic leukemia (T-ALL) remains an open question. We hypothesized that a modified cytogenetic classification, based on the number and type of cytogenetic abnormalities, would allow the identification of high-risk...

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Autores: Genescà, Eulàlia|||0000-0002-5657-4842, Morgades, Mireia|||0000-0003-0295-2534, González-Gil, Celia, Fuster-Tormo, Francisco|||0000-0002-1220-6183, Haferlach, Claudia, Meggendorfer, Manja, Montesinos, Pau|||0000-0002-3275-5593, Barba, Pere|||0000-0001-7076-7969, Gil, Cristina, Coll, Rosa|||0000-0003-0560-1254, Moreno, Maria José, Martínez-Carballeira, Daniel|||0000-0003-4840-7822, García Cadenas, Irene|||0000-0002-2994-9055, Vives Polo, Susana|||0000-0003-2217-5285, Ribera Salas, Jordi|||0000-0002-0288-4220, González Campos, José, Díaz-Beyá, Marina|||0000-0001-9624-2597, Mercadal, Santiago|||0000-0003-4741-7885, Artola, Maria Teresa, Cladera, Antonia, Tormo, Mar|||0000-0001-9622-1649, Bermúdez, Arancha, Vall-Llovera, Ferran|||0000-0002-0718-5955, Martínez Sánchez, Pilar|||0000-0002-7334-140X, Amigo, María-Luz|||0000-0002-3356-9290, Monsalvo, Silvia, Novo, Andrés, Cervera, Marta, García-Guiñon, Antonio, Ciudad Pizarro, Juana, Cervera, José|||0000-0001-8252-1106, Hernández Rivas, Jesús María|||0000-0002-9661-9371, Granada, Isabel|||0000-0002-4275-0104, Haferlach, T.|||0000-0003-0196-2837, Orfao, Alberto|||0000-0002-0007-7230, Sole, F.|||0000-0002-3251-2161, Ribera, Jose-Maria|||0000-0003-1042-6024
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:270259
Acceso en línea:https://ddd.uab.cat/record/270259
https://dx.doi.org/urn:doi:10.1016/j.leukres.2021.106612
Access Level:acceso abierto
Palabra clave:Prognosis
Cytogenetics
Adult T-ALL
NGS
Therapy
Descripción
Sumario:The potential prognostic value of conventional karyotyping in adult T-cell acute lymphoblastic leukemia (T-ALL) remains an open question. We hypothesized that a modified cytogenetic classification, based on the number and type of cytogenetic abnormalities, would allow the identification of high-risk adult T-ALL patients. Complex karyotype defined by the presence of ≥3 cytogenetic alterations identified T-ALL patients with poor prognosis in this study. Karyotypes with ≥3 abnormalities accounted for 16 % (22/139) of all evaluable karyotypes, corresponding to the largest poor prognosis cytogenetic subgroup of T-ALL identified so far. Patients carrying karyotypes with ≥3 cytogenetic alterations showed a significantly inferior response to therapy, and a poor outcome in terms of event-free survival (EFS), overall survival (OS) and cumulative incidence of relapse (CIR), independently of other baseline characteristics and the end-induction minimal residual disease (MRD) level. Additional molecular analyses of patients carrying ≥3 cytogenetic alterations showed a unique molecular profile that could contribute to understand the underlying molecular mechanisms of resistance and to evaluate novel targeted therapies (e.g. IL7R directed) with potential impact on outcome of adult T-ALL patients.

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