Adverse prognostic impact of complex karyotype (≥3 cytogenetic alterations) in adult T-cell acute lymphoblastic leukemia (T-ALL)

The potential prognostic value of conventional karyotyping in adult T-cell acute lymphoblastic leukemia (T-ALL) remains an open question. We hypothesized that a modified cytogenetic classification, based on the number and type of cytogenetic abnormalities, would allow the identification of high-risk...

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Detalles Bibliográficos
Autores: Genescà, Eulàlia, Morgades, Mireia, González Gil, Celia, Fuster Tormo, Francisco, Haferlach, Claudia, Meggendorfer, Manja, Montesinos, Pau, Barba, Pere, Gil, Cristina, Coll, Rosa, Moreno, María José, Martínez Carballeira, Daniel, García Cadenas, Irene, Vives, Susana, Ribera, Jordi, González Campos, José, Díaz Beyà, Marina, Mercadal, Santiago, Artola, María Teresa, Cladera, Antonia, Tormo, Mar, Bermúdez, Arancha, Vall Llovera, Ferran, Martínez Sánchez, Pilar, Amigo, María Luz, Monsalvo, Silvia, Novo, Andrés, Cervera, Marta, García Guiñon, Antonio, Ciudad, Juana, Cervera, José, Hernández Rivas, Jesús María, Granada, Isabel, Haferlach, Torsten, Orfao, Alberto, Solé, Francesc, Ribera, Josep Maria
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/180372
Acceso en línea:https://hdl.handle.net/2445/180372
Access Level:acceso abierto
Palabra clave:Citogenètica humana
Leucèmia
Pronòstic mèdic
Human cytogenetics
Leukemia
Prognosis
Descripción
Sumario:The potential prognostic value of conventional karyotyping in adult T-cell acute lymphoblastic leukemia (T-ALL) remains an open question. We hypothesized that a modified cytogenetic classification, based on the number and type of cytogenetic abnormalities, would allow the identification of high-risk adult T-ALL patients. Complex karyotype defined by the presence of ≥3 cytogenetic alterations identified T-ALL patients with poor prognosis in this study. Karyotypes with ≥3 abnormalities accounted for 16 % (22/139) of all evaluable karyotypes, corresponding to the largest poor prognosis cytogenetic subgroup of T-ALL identified so far. Patients carrying karyotypes with ≥3 cytogenetic alterations showed a significantly inferior response to therapy, and a poor outcome in terms of event-free survival (EFS), overall survival (OS) and cumulative incidence of relapse (CIR), independently of other baseline characteristics and the end-induction minimal residual disease (MRD) level. Additional molecular analyses of patients carrying ≥3 cytogenetic alterations showed a unique molecular profile that could contribute to understand the underlying molecular mechanisms of resistance and to evaluate novel targeted therapies (e.g. IL7R directed) with potential impact on outcome of adult T-ALL patients.

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