Functional cure of a chronic virus infection by shifting the virus - host equilibrium state
The clinical handling of chronic virus infections remains a challenge. Here we describe recent progress in the understanding of virus - host interaction dynamics. Based on the systems biology concept of multi-stability and the prediction of multiplicative cooperativity between virus-specific cytotox...
| Autores: | , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universitat Pompeu Fabra |
| Repositorio: | Repositorio Digital de la UPF |
| OAI Identifier: | oai:repositori.upf.edu:10230/54831 |
| Acceso en línea: | http://hdl.handle.net/10230/54831 http://dx.doi.org/10.3389/fimmu.2022.904342 |
| Access Level: | acceso abierto |
| Palabra clave: | Chronic virus infections HIV (human immunodeficiency virus) LCMV (lymphocytic choriomeningitis virus) Cure strategies Multi-stability Shifting equilibrium states |
| Sumario: | The clinical handling of chronic virus infections remains a challenge. Here we describe recent progress in the understanding of virus - host interaction dynamics. Based on the systems biology concept of multi-stability and the prediction of multiplicative cooperativity between virus-specific cytotoxic T cells and neutralising antibodies, we argue for the requirements to engage multiple immune system components for functional cure strategies. Our arguments are derived from LCMV model system studies and are translated to HIV-1 infection. |
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