Functional cure of a chronic virus infection by shifting the virus - host equilibrium state
The clinical handling of chronic virus infections remains a challenge. Here we describe recent progress in the understanding of virus - host interaction dynamics. Based on the systems biology concept of multi-stability and the prediction of multiplicative cooperativity between virus-specific cytotox...
| Autores: | , , , , , |
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| Tipo de documento: | artigo |
| Estado: | Versão publicada |
| Data de publicação: | 2022 |
| País: | España |
| Recursos: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositório: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10230/54831 |
| Acesso em linha: | http://hdl.handle.net/10230/54831 http://dx.doi.org/10.3389/fimmu.2022.904342 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Chronic virus infections HIV (human immunodeficiency virus) LCMV (lymphocytic choriomeningitis virus) Cure strategies Multi-stability Shifting equilibrium states |
| Resumo: | The clinical handling of chronic virus infections remains a challenge. Here we describe recent progress in the understanding of virus - host interaction dynamics. Based on the systems biology concept of multi-stability and the prediction of multiplicative cooperativity between virus-specific cytotoxic T cells and neutralising antibodies, we argue for the requirements to engage multiple immune system components for functional cure strategies. Our arguments are derived from LCMV model system studies and are translated to HIV-1 infection. |
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