Inflammatory potential of diet and bone mineral density in a senior Mediterranean population: a cross-sectional analysis of PREDIMED-Plus study
[EN] Purpose: Inflammation could play a key role in tissue damage and bone metabolism. The modified dietary inflammatory score (M-DIS) is a validated tool to estimate the inflammatory potential of the diet. In the present study, we evaluate the associations between the M-DIS and bone mineral density...
| Autores: | , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universidad Rey Juan Carlos |
| Repositorio: | BULERIA. Repositorio Institucional de la Universidad de León |
| OAI Identifier: | oai:buleria.unileon.es:10612/18231 |
| Acceso en línea: | https://link.springer.com/article/10.1007/s00394-021-02751-5 https://hdl.handle.net/10612/18231 |
| Access Level: | acceso abierto |
| Palabra clave: | Medicina. Salud Bone mineral density Diet Inflammation Osteoporosis 32 Ciencias Médicas |
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España |
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| dc.title.none.fl_str_mv |
Inflammatory potential of diet and bone mineral density in a senior Mediterranean population: a cross-sectional analysis of PREDIMED-Plus study Potencial inflamatorio de la dieta y densidad mineral ósea en una población mediterránea senior: un análisis transversal del estudio PREDIMED-Plus |
| title |
Inflammatory potential of diet and bone mineral density in a senior Mediterranean population: a cross-sectional analysis of PREDIMED-Plus study |
| spellingShingle |
Inflammatory potential of diet and bone mineral density in a senior Mediterranean population: a cross-sectional analysis of PREDIMED-Plus study García Gavilán, Jesús Francisco Medicina. Salud Bone mineral density Diet Inflammation Osteoporosis 32 Ciencias Médicas |
| title_short |
Inflammatory potential of diet and bone mineral density in a senior Mediterranean population: a cross-sectional analysis of PREDIMED-Plus study |
| title_full |
Inflammatory potential of diet and bone mineral density in a senior Mediterranean population: a cross-sectional analysis of PREDIMED-Plus study |
| title_fullStr |
Inflammatory potential of diet and bone mineral density in a senior Mediterranean population: a cross-sectional analysis of PREDIMED-Plus study |
| title_full_unstemmed |
Inflammatory potential of diet and bone mineral density in a senior Mediterranean population: a cross-sectional analysis of PREDIMED-Plus study |
| title_sort |
Inflammatory potential of diet and bone mineral density in a senior Mediterranean population: a cross-sectional analysis of PREDIMED-Plus study |
| dc.creator.none.fl_str_mv |
García Gavilán, Jesús Francisco Paz Graniel, Indira Babio, Nancy Romaguera, Dora Martínez, José Alfredo Martín Sánchez, Vicente Martínez, María Ángeles Konieczna, Jadwiga Ruiz Canela, Miguel Paz Fernández, José Antonio de Goday, Albert Martínez González, Miguel Ángel Bulló, Mònica Salas Salvadó, Jordi |
| author |
García Gavilán, Jesús Francisco |
| author_facet |
García Gavilán, Jesús Francisco Paz Graniel, Indira Babio, Nancy Romaguera, Dora Martínez, José Alfredo Martín Sánchez, Vicente Martínez, María Ángeles Konieczna, Jadwiga Ruiz Canela, Miguel Paz Fernández, José Antonio de Goday, Albert Martínez González, Miguel Ángel Bulló, Mònica Salas Salvadó, Jordi |
| author_role |
author |
| author2 |
Paz Graniel, Indira Babio, Nancy Romaguera, Dora Martínez, José Alfredo Martín Sánchez, Vicente Martínez, María Ángeles Konieczna, Jadwiga Ruiz Canela, Miguel Paz Fernández, José Antonio de Goday, Albert Martínez González, Miguel Ángel Bulló, Mònica Salas Salvadó, Jordi |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Medicina Preventiva Instituto Universitario de Biomedicina (IBIOMED) |
| dc.subject.none.fl_str_mv |
Medicina. Salud Bone mineral density Diet Inflammation Osteoporosis 32 Ciencias Médicas |
| topic |
Medicina. Salud Bone mineral density Diet Inflammation Osteoporosis 32 Ciencias Médicas |
| description |
[EN] Purpose: Inflammation could play a key role in tissue damage and bone metabolism. The modified dietary inflammatory score (M-DIS) is a validated tool to estimate the inflammatory potential of the diet. In the present study, we evaluate the associations between the M-DIS and bone mineral density (BMD) in a senior Mediterranean population with overweight/obesity and metabolic syndrome. Methods: Baseline cross-sectional association between the M-DIS and bone mineral density was assessed in 1134 participants of the multicenter PREDIMED-Plus trial (aged 55-75 with overweight/obesity and metabolic syndrome). BMD was measured using Dual-energy X-ray Absorptiometry scans and participants answered a food frequency questionnaire to determine the M-DIS. BMD was categorized as low BMD when T score was equal or lower than -1 and normal BMD in another case. Associations between BMD and M-DIS were evaluated by using linear and logistic regressions adjusted by other co-variates. Results: Participants in the top tertile of the M-DIS had a lower BMD at total femur [β (95% CI) - 0.02 (- 0.04, - 0.01)], trochanter areas [β (95% CI) - 0.03 (- 0.05, - 0.01)] and lumbar spine area [β (95% CI) - 0.03 (- 0.07, 0.01)] (but in the last case, measures were less precise and hence not statistically significant) compared to those in the lower M-DIS tertile. Multiple logistic regression analyses showed that the odds of the total femur and femoral trochanter osteopenia/osteoporosis were higher in participants in the top tertile compared to those in the lowest tertile of M-DIS [OR (95% CI) 1.71 (1.12, 2.64), P for trend 0.015; 2.02 (1.29, 3.21), P for trend 0.002, respectively]. Conclusion: A high pro-inflammatory diet, measured by the M-DIS, is associated with lower BMD in a senior Mediterranean population with metabolic syndrome. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://link.springer.com/article/10.1007/s00394-021-02751-5 https://hdl.handle.net/10612/18231 |
| url |
https://link.springer.com/article/10.1007/s00394-021-02751-5 https://hdl.handle.net/10612/18231 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.rights.none.fl_str_mv |
http://creativecommons.org/licenses/by-nd/4.0/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nd/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Springer |
| publisher.none.fl_str_mv |
Springer |
| dc.source.none.fl_str_mv |
reponame:BULERIA. Repositorio Institucional de la Universidad de León instname:Universidad Rey Juan Carlos |
| instname_str |
Universidad Rey Juan Carlos |
| reponame_str |
BULERIA. Repositorio Institucional de la Universidad de León |
| collection |
BULERIA. Repositorio Institucional de la Universidad de León |
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| _version_ |
1869406561778008064 |
| spelling |
Inflammatory potential of diet and bone mineral density in a senior Mediterranean population: a cross-sectional analysis of PREDIMED-Plus studyPotencial inflamatorio de la dieta y densidad mineral ósea en una población mediterránea senior: un análisis transversal del estudio PREDIMED-PlusGarcía Gavilán, Jesús FranciscoPaz Graniel, IndiraBabio, NancyRomaguera, DoraMartínez, José AlfredoMartín Sánchez, VicenteMartínez, María ÁngelesKonieczna, JadwigaRuiz Canela, MiguelPaz Fernández, José Antonio deGoday, AlbertMartínez González, Miguel ÁngelBulló, MònicaSalas Salvadó, JordiMedicina. SaludBone mineral densityDietInflammationOsteoporosis32 Ciencias Médicas[EN] Purpose: Inflammation could play a key role in tissue damage and bone metabolism. The modified dietary inflammatory score (M-DIS) is a validated tool to estimate the inflammatory potential of the diet. In the present study, we evaluate the associations between the M-DIS and bone mineral density (BMD) in a senior Mediterranean population with overweight/obesity and metabolic syndrome. Methods: Baseline cross-sectional association between the M-DIS and bone mineral density was assessed in 1134 participants of the multicenter PREDIMED-Plus trial (aged 55-75 with overweight/obesity and metabolic syndrome). BMD was measured using Dual-energy X-ray Absorptiometry scans and participants answered a food frequency questionnaire to determine the M-DIS. BMD was categorized as low BMD when T score was equal or lower than -1 and normal BMD in another case. Associations between BMD and M-DIS were evaluated by using linear and logistic regressions adjusted by other co-variates. Results: Participants in the top tertile of the M-DIS had a lower BMD at total femur [β (95% CI) - 0.02 (- 0.04, - 0.01)], trochanter areas [β (95% CI) - 0.03 (- 0.05, - 0.01)] and lumbar spine area [β (95% CI) - 0.03 (- 0.07, 0.01)] (but in the last case, measures were less precise and hence not statistically significant) compared to those in the lower M-DIS tertile. Multiple logistic regression analyses showed that the odds of the total femur and femoral trochanter osteopenia/osteoporosis were higher in participants in the top tertile compared to those in the lowest tertile of M-DIS [OR (95% CI) 1.71 (1.12, 2.64), P for trend 0.015; 2.02 (1.29, 3.21), P for trend 0.002, respectively]. Conclusion: A high pro-inflammatory diet, measured by the M-DIS, is associated with lower BMD in a senior Mediterranean population with metabolic syndrome.SIWe acknowledge and appreciate all the work of the PREDIMED-Plus personnel, and are grateful for all support received from Rovira i Virgili University (URV), Pere Virgili Institute (IISPV), and Sant Joan Hospital.Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. The PREDIMED-Plus study was supported by the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund of the Spanish Ministry of Health (ISCIII) (PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332, PI20/01802, PI20/00138, PI20/01532, PI20/00456, PI20/00339, PI20/00557, PI20/00886, PI20/01158); the European Research Council (Advanced Research Grant 2013–2018, 340918); the Recercaixa grant 2013 (2013ACUP00194); the Consejería de Salud de la Junta de Andalucía (PI0458/2013); and the Semergen grant; the National Institutes of Health (R01DK127601); the ‘FOLIUM’ programme within the FUTURMed project from the Fundación Instituto de Investigación Sanitaria Illes Balears (fnanced by 2017annual plan of the sustainable tourism tax and at 50% with charge to the ESF Operational Program 2014–2020 of the Balearic Islands) to J. Konieczna. Consorcio Ciber de Obesidad y Nutrición (CIBEROBN), Consorcio Ciber de Epidemiología y Salud Pública (CIBERESP), and Consorcio de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM) are initiatives of ISCIII, Spain. Jordi Salas-Salvadó, senior author of this study, is partially supported by ICREA under the ICREA Academia programme. JFG-G has received the Contratos Pre-doctorales de Formación en Investigación en Salud (PFIS FI17/00255) of the Acción Estratégica en Salud program (AES) from the Carlos III Health Institute (ISCIII), Spanish Ministry of Health. IP-G receives a grant from the Ministerio de Ciencia, Innovación y Universidades (MICINN) (FPU 17/01925)SpringerMedicina PreventivaInstituto Universitario de Biomedicina (IBIOMED)2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://link.springer.com/article/10.1007/s00394-021-02751-5https://hdl.handle.net/10612/18231reponame:BULERIA. Repositorio Institucional de la Universidad de Leóninstname:Universidad Rey Juan CarlosIngléshttp://creativecommons.org/licenses/by-nd/4.0/info:eu-repo/semantics/openAccessoai:buleria.unileon.es:10612/182312026-06-24T12:43:27Z |
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15,301603 |