Inflammatory potential of diet and bone mineral density in a senior Mediterranean population: a cross‑sectional analysis of PREDIMED‑Plus study

Purpose: Inflammation could play a key role in tissue damage and bone metabolism. The modified dietary inflammatory score (M-DIS) is a validated tool to estimate the inflammatory potential of the diet. In the present study, we evaluate the associations between the M-DIS and bone mineral density (BMD...

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Autores: García-Gavilán, J.F. (Jesús F.)|||/items/9718a7cb-f470-49b0-b6bf-7771720eb20a, Paz-Graniel, I. (Indira)|||/items/a7ab71d8-490e-4196-befe-165e8223aa6d, Babio, N. (Nancy)|||/items/5b6a2a17-b695-4712-9e4d-e9f3371dcc3c, Romaguera, D. (Dora)|||/items/54bd463f-ee9f-4c7a-b33e-78633766680a, Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131, Martin, V. (Vicente)|||/items/f5e6eab9-a1d6-488b-adc9-10bdb0e4a2a5, Martínez, M.A. (María Ángeles)|||/items/3ef242ee-a343-4c86-acc0-df0a38cc4817, Konieczna, J. (Jadwiga)|||/items/e556dd7a-a024-4f5a-8e4d-0f2c84b78aa1, Ruiz-Canela, M. (Miguel)|||/items/e333fb32-07a9-4253-a095-1cea0db0f7e9, Paz, J.A. (José Antonio) de|||/items/24121fed-bbf5-4d6c-b625-6c9d6d4a4196, Goday, A. (Albert)|||/items/81b2667a-289a-44b9-b057-66c15f307542, Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7, Bullo, M. (Monica)|||/items/d8fb42f6-4284-48ef-9dc1-e84db1841835, Salas-Salvado, J. (Jordi)|||/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dnet:dadun_______::45d2f7dbe82e7c6f392131414380a1e4
Acceso en línea:https://hdl.handle.net/10171/124543
Access Level:acceso abierto
Palabra clave:Bone mineral density
Diet
Inflammation
Osteoporosis
Descripción
Sumario:Purpose: Inflammation could play a key role in tissue damage and bone metabolism. The modified dietary inflammatory score (M-DIS) is a validated tool to estimate the inflammatory potential of the diet. In the present study, we evaluate the associations between the M-DIS and bone mineral density (BMD) in a senior Mediterranean population with overweight/obesity and metabolic syndrome. Methods: Baseline cross-sectional association between the M-DIS and bone mineral density was assessed in 1134 participants of the multicenter PREDIMED-Plus trial (aged 55-75 with overweight/obesity and metabolic syndrome). BMD was measured using Dual-energy X-ray Absorptiometry scans and participants answered a food frequency questionnaire to determine the M-DIS. BMD was categorized as low BMD when T score was equal or lower than -1 and normal BMD in another case. Associations between BMD and M-DIS were evaluated by using linear and logistic regressions adjusted by other co-variates. Results: Participants in the top tertile of the M-DIS had a lower BMD at total femur [β (95% CI) - 0.02 (- 0.04, - 0.01)], trochanter areas [β (95% CI) - 0.03 (- 0.05, - 0.01)] and lumbar spine area [β (95% CI) - 0.03 (- 0.07, 0.01)] (but in the last case, measures were less precise and hence not statistically significant) compared to those in the lower M-DIS tertile. Multiple logistic regression analyses showed that the odds of the total femur and femoral trochanter osteopenia/osteoporosis were higher in participants in the top tertile compared to those in the lowest tertile of M-DIS [OR (95% CI) 1.71 (1.12, 2.64), P for trend 0.015; 2.02 (1.29, 3.21), P for trend 0.002, respectively]. Conclusion: A high pro-inflammatory diet, measured by the M-DIS, is associated with lower BMD in a senior Mediterranean population with metabolic syndrome.

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