Lack Of Association Between Jak3 Gene Polymorphisms And Cardiovascular Disease In Spanish Patients With Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a polygenic disease associated with accelerated atherosclerosis and increased cardiovascular (CV) mortality. JAK/STAT signalling pathway is involved in autoimmune diseases and in the atherosclerotic process. JAK3 is a highly promising target for immunomodulatory drugs an...

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Autores: García Bermúdez, Mercedes, López Mejías, Raquel, Genre, Fernanda, Castañeda, Santos, Corrales, Alfonso, Llorca Díaz, Javier, González Juanatey, Carlos, Ubilla, Begoña, Miranda-Filloy, José A., Pina, Trinitario, Gómez Vaquero, Carmen, Rodríguez-Rodríguez, Luis, Fernández Gutiérrez, Benjamín, Balsa, Alejandro, Pascual-Salcedo, Dora, López Longo, Francisco J., Carreira, Patricia, Blanco, Ricardo, Martín, Javier, González-Gay, Miguel A.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/126169
Acceso en línea:https://hdl.handle.net/2445/126169
Access Level:acceso abierto
Palabra clave:Artritis reumatoide
Malalties cardiovasculars
Rheumatoid arthritis
Cardiovascular diseases
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spelling Lack Of Association Between Jak3 Gene Polymorphisms And Cardiovascular Disease In Spanish Patients With Rheumatoid ArthritisGarcía Bermúdez, MercedesLópez Mejías, RaquelGenre, FernandaCastañeda, SantosCorrales, AlfonsoLlorca Díaz, JavierGonzález Juanatey, CarlosUbilla, BegoñaMiranda-Filloy, José A.Pina, TrinitarioGómez Vaquero, CarmenRodríguez-Rodríguez, LuisFernández Gutiérrez, BenjamínBalsa, AlejandroPascual-Salcedo, DoraLópez Longo, Francisco J.Carreira, PatriciaBlanco, RicardoMartín, JavierGonzález-Gay, Miguel A.Artritis reumatoideMalalties cardiovascularsRheumatoid arthritisCardiovascular diseasesRheumatoid arthritis (RA) is a polygenic disease associated with accelerated atherosclerosis and increased cardiovascular (CV) mortality. JAK/STAT signalling pathway is involved in autoimmune diseases and in the atherosclerotic process. JAK3 is a highly promising target for immunomodulatory drugs and polymorphisms in JAK3 gene have been associated with CV events in incident dialysis patients. Therefore, the aim of this study was to assess the potential role of JAK3 polymorphisms in the development of CV disease in patients with RA. 2136 Spanish RA patients were genotyped for the rs3212780 and rs3212752 JAK3 gene polymorphisms by TaqMan assays. Subclinical atherosclerosis was evaluated in 539 of these patients by carotid ultrasonography (US). No statistically significant differences were found when each polymorphism was assessed according to carotid intima-media thickness values and presence/absence of carotid plaques in RA, after adjusting the results for potential confounders. Moreover, no significant differences were obtained when RA patients were stratified according to the presence/absence of CV events after adjusting for potential confounders. In conclusion, our results do not confirm association between JAK3 polymorphisms and CV disease in RA.Hindawi Publishing Corporation2018201820152018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion11 p.application/pdfhttps://hdl.handle.net/2445/126169Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1155/2015/318364BioMed Research International, 2015,https://doi.org/10.1155/2015/318364cc by (c) García Bermúdez et al., 2015http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1261692026-05-29T05:05:01Z
dc.title.none.fl_str_mv Lack Of Association Between Jak3 Gene Polymorphisms And Cardiovascular Disease In Spanish Patients With Rheumatoid Arthritis
title Lack Of Association Between Jak3 Gene Polymorphisms And Cardiovascular Disease In Spanish Patients With Rheumatoid Arthritis
spellingShingle Lack Of Association Between Jak3 Gene Polymorphisms And Cardiovascular Disease In Spanish Patients With Rheumatoid Arthritis
García Bermúdez, Mercedes
Artritis reumatoide
Malalties cardiovasculars
Rheumatoid arthritis
Cardiovascular diseases
title_short Lack Of Association Between Jak3 Gene Polymorphisms And Cardiovascular Disease In Spanish Patients With Rheumatoid Arthritis
title_full Lack Of Association Between Jak3 Gene Polymorphisms And Cardiovascular Disease In Spanish Patients With Rheumatoid Arthritis
title_fullStr Lack Of Association Between Jak3 Gene Polymorphisms And Cardiovascular Disease In Spanish Patients With Rheumatoid Arthritis
title_full_unstemmed Lack Of Association Between Jak3 Gene Polymorphisms And Cardiovascular Disease In Spanish Patients With Rheumatoid Arthritis
title_sort Lack Of Association Between Jak3 Gene Polymorphisms And Cardiovascular Disease In Spanish Patients With Rheumatoid Arthritis
dc.creator.none.fl_str_mv García Bermúdez, Mercedes
López Mejías, Raquel
Genre, Fernanda
Castañeda, Santos
Corrales, Alfonso
Llorca Díaz, Javier
González Juanatey, Carlos
Ubilla, Begoña
Miranda-Filloy, José A.
Pina, Trinitario
Gómez Vaquero, Carmen
Rodríguez-Rodríguez, Luis
Fernández Gutiérrez, Benjamín
Balsa, Alejandro
Pascual-Salcedo, Dora
López Longo, Francisco J.
Carreira, Patricia
Blanco, Ricardo
Martín, Javier
González-Gay, Miguel A.
author García Bermúdez, Mercedes
author_facet García Bermúdez, Mercedes
López Mejías, Raquel
Genre, Fernanda
Castañeda, Santos
Corrales, Alfonso
Llorca Díaz, Javier
González Juanatey, Carlos
Ubilla, Begoña
Miranda-Filloy, José A.
Pina, Trinitario
Gómez Vaquero, Carmen
Rodríguez-Rodríguez, Luis
Fernández Gutiérrez, Benjamín
Balsa, Alejandro
Pascual-Salcedo, Dora
López Longo, Francisco J.
Carreira, Patricia
Blanco, Ricardo
Martín, Javier
González-Gay, Miguel A.
author_role author
author2 López Mejías, Raquel
Genre, Fernanda
Castañeda, Santos
Corrales, Alfonso
Llorca Díaz, Javier
González Juanatey, Carlos
Ubilla, Begoña
Miranda-Filloy, José A.
Pina, Trinitario
Gómez Vaquero, Carmen
Rodríguez-Rodríguez, Luis
Fernández Gutiérrez, Benjamín
Balsa, Alejandro
Pascual-Salcedo, Dora
López Longo, Francisco J.
Carreira, Patricia
Blanco, Ricardo
Martín, Javier
González-Gay, Miguel A.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Artritis reumatoide
Malalties cardiovasculars
Rheumatoid arthritis
Cardiovascular diseases
topic Artritis reumatoide
Malalties cardiovasculars
Rheumatoid arthritis
Cardiovascular diseases
description Rheumatoid arthritis (RA) is a polygenic disease associated with accelerated atherosclerosis and increased cardiovascular (CV) mortality. JAK/STAT signalling pathway is involved in autoimmune diseases and in the atherosclerotic process. JAK3 is a highly promising target for immunomodulatory drugs and polymorphisms in JAK3 gene have been associated with CV events in incident dialysis patients. Therefore, the aim of this study was to assess the potential role of JAK3 polymorphisms in the development of CV disease in patients with RA. 2136 Spanish RA patients were genotyped for the rs3212780 and rs3212752 JAK3 gene polymorphisms by TaqMan assays. Subclinical atherosclerosis was evaluated in 539 of these patients by carotid ultrasonography (US). No statistically significant differences were found when each polymorphism was assessed according to carotid intima-media thickness values and presence/absence of carotid plaques in RA, after adjusting the results for potential confounders. Moreover, no significant differences were obtained when RA patients were stratified according to the presence/absence of CV events after adjusting for potential confounders. In conclusion, our results do not confirm association between JAK3 polymorphisms and CV disease in RA.
publishDate 2015
dc.date.none.fl_str_mv 2015
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/126169
url https://hdl.handle.net/2445/126169
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1155/2015/318364
BioMed Research International, 2015,
https://doi.org/10.1155/2015/318364
dc.rights.none.fl_str_mv cc by (c) García Bermúdez et al., 2015
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) García Bermúdez et al., 2015
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11 p.
application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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