Lack Of Association Between Jak3 Gene Polymorphisms And Cardiovascular Disease In Spanish Patients With Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a polygenic disease associated with accelerated atherosclerosis and increased cardiovascular (CV) mortality. JAK/STAT signalling pathway is involved in autoimmune diseases and in the atherosclerotic process. JAK3 is a highly promising target for immunomodulatory drugs an...

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Detalles Bibliográficos
Autores: García Bermúdez, Mercedes, López Mejías, Raquel, Genre, Fernanda, Castañeda, Santos, Corrales, Alfonso, Llorca Díaz, Javier, González Juanatey, Carlos, Ubilla, Begoña, Miranda-Filloy, José A., Pina, Trinitario, Gómez Vaquero, Carmen, Rodríguez-Rodríguez, Luis, Fernández Gutiérrez, Benjamín, Balsa, Alejandro, Pascual-Salcedo, Dora, López Longo, Francisco J., Carreira, Patricia, Blanco, Ricardo, Martín, Javier, González-Gay, Miguel A.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/126169
Acceso en línea:https://hdl.handle.net/2445/126169
Access Level:acceso abierto
Palabra clave:Artritis reumatoide
Malalties cardiovasculars
Rheumatoid arthritis
Cardiovascular diseases
Descripción
Sumario:Rheumatoid arthritis (RA) is a polygenic disease associated with accelerated atherosclerosis and increased cardiovascular (CV) mortality. JAK/STAT signalling pathway is involved in autoimmune diseases and in the atherosclerotic process. JAK3 is a highly promising target for immunomodulatory drugs and polymorphisms in JAK3 gene have been associated with CV events in incident dialysis patients. Therefore, the aim of this study was to assess the potential role of JAK3 polymorphisms in the development of CV disease in patients with RA. 2136 Spanish RA patients were genotyped for the rs3212780 and rs3212752 JAK3 gene polymorphisms by TaqMan assays. Subclinical atherosclerosis was evaluated in 539 of these patients by carotid ultrasonography (US). No statistically significant differences were found when each polymorphism was assessed according to carotid intima-media thickness values and presence/absence of carotid plaques in RA, after adjusting the results for potential confounders. Moreover, no significant differences were obtained when RA patients were stratified according to the presence/absence of CV events after adjusting for potential confounders. In conclusion, our results do not confirm association between JAK3 polymorphisms and CV disease in RA.

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