A Straightforward Synthesis of Functionalized cis-Perhydroisoquinolin-1-ones

Base-catalyzed annulation reactions of 5,6-dihydro-2(1H)-pyridones with Nazarov-type reagents are reported. The effect of the solvent polarity and the concentration of the reagents is studied. The process involves two successive Michael additions and stereoselectively provides functionalized cis-per...

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Detalles Bibliográficos
Autores: Arioli, Federica, Pérez Bosch, Maria, Are, Celeste, Molins i Grau, Elies, Bosch Cartes, Joan, Amat Tusón, Mercedes
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/174410
Acceso en línea:https://hdl.handle.net/2445/174410
Access Level:acceso abierto
Palabra clave:Indicadors (Química)
Proves i reactius químics
Lactames
Química orgànica
Indicators and test-papers
Chemical tests and reagents
Lactams
Organic chemistry
Descripción
Sumario:Base-catalyzed annulation reactions of 5,6-dihydro-2(1H)-pyridones with Nazarov-type reagents are reported. The effect of the solvent polarity and the concentration of the reagents is studied. The process involves two successive Michael additions and stereoselectively provides functionalized cis-perhydroisoquinolin-1-ones.