Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients
BackgroundPrevious studies comparing immigrant ethnic groups and native patients with IBD have yielded clinical and phenotypic differences. To date, no study has focused on the immigrant IBD population in Spain. MethodsProspective, observational, multicenter study comparing cohorts of IBD patients f...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau) |
| Repositorio: | r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau |
| OAI Identifier: | oai:iibsantpau.fundanetsuite.com:p7677 |
| Acceso en línea: | https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=7677 |
| Access Level: | acceso abierto |
| Palabra clave: | immigrant phenotype biologics inflammatory bowel disease Crohn's disease ulcerative colitis |
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Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native PatientsGutierrez, AZapater, PRicart, EGonzalez-Vivo, MGordillo, JOlivares, DVera, IManosa, MGisbert, JPAguas, MSanchez-Rodriguez, EBosca-Watts, MLaredo, VCamps, BMarin-Jimenez, IZabana, YMartin-Arranz, MDMunoz, RNavarro, MSierra, EMadero, LVela, MPerez-Calle, JLSainz, ECalvet, XArias, LMorales, VBermejo, FFernandez-Salazar, LVan Domselaar, MDe Castro, LRodriguez, CMunoz-Villafranca, CLorente, RRivero, MIglesias, EHerreros, BBusquets, DRiera, JMartinez-Montiel, MPRoldon, MRoncero, OHinojosa, ESierra, MBarrio, JDe Francisco, RHuguet, JMerino, OCarpio, DGinard, DMunoz, FMarta, PAlmela, PArgueelles-Arias, FAlcain, GLuis, BMancenido, NLucendo, AJVarela, PRodriguez-Lago, IRamos, LLaura, SSese, EAcosta, MBDDomenech, EFrances, Rimmigrantphenotypebiologicsinflammatory bowel diseaseCrohn's diseaseulcerative colitisBackgroundPrevious studies comparing immigrant ethnic groups and native patients with IBD have yielded clinical and phenotypic differences. To date, no study has focused on the immigrant IBD population in Spain. MethodsProspective, observational, multicenter study comparing cohorts of IBD patients from ENEIDA-registry who were born outside Spain with a cohort of native patients. ResultsWe included 13,524 patients (1,864 immigrant and 11,660 native). The immigrants were younger (45 +/- 12 vs. 54 +/- 16 years, p < 0.001), had been diagnosed younger (31 +/- 12 vs. 36 +/- 15 years, p < 0.001), and had a shorter disease duration (14 +/- 7 vs. 18 +/- 8 years, p < 0.001) than native patients. Family history of IBD (9 vs. 14%, p < 0.001) and smoking (30 vs. 40%, p < 0.001) were more frequent among native patients. The most prevalent ethnic groups among immigrants were Caucasian (41.5%), followed by Latin American (30.8%), Arab (18.3%), and Asian (6.7%). Extraintestinal manifestations, mainly musculoskeletal affections, were more frequent in immigrants (19 vs. 11%, p < 0.001). Use of biologics, mainly anti-TNF, was greater in immigrants (36 vs. 29%, p < 0.001). The risk of having extraintestinal manifestations [OR: 2.23 (1.92-2.58, p < 0.001)] and using biologics [OR: 1.13 (1.0-1.26, p = 0.042)] was independently associated with immigrant status in the multivariate analyses. ConclusionsCompared with native-born patients, first-generation-immigrant IBD patients in Spain were younger at disease onset and showed an increased risk of having extraintestinal manifestations and using biologics. Our study suggests a featured phenotype of immigrant IBD patients in Spain, and constitutes a new landmark in the epidemiological characterization of immigrant IBD populations in Southern Europe.FRONTIERS MEDIA SA2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=7677Frontiers in MedicineISSN: 2296858Xreponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p76772026-06-14T12:41:47Z |
| dc.title.none.fl_str_mv |
Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients |
| title |
Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients |
| spellingShingle |
Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients Gutierrez, A immigrant phenotype biologics inflammatory bowel disease Crohn's disease ulcerative colitis |
| title_short |
Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients |
| title_full |
Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients |
| title_fullStr |
Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients |
| title_full_unstemmed |
Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients |
| title_sort |
Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients |
| dc.creator.none.fl_str_mv |
Gutierrez, A Zapater, P Ricart, E Gonzalez-Vivo, M Gordillo, J Olivares, D Vera, I Manosa, M Gisbert, JP Aguas, M Sanchez-Rodriguez, E Bosca-Watts, M Laredo, V Camps, B Marin-Jimenez, I Zabana, Y Martin-Arranz, MD Munoz, R Navarro, M Sierra, E Madero, L Vela, M Perez-Calle, JL Sainz, E Calvet, X Arias, L Morales, V Bermejo, F Fernandez-Salazar, L Van Domselaar, M De Castro, L Rodriguez, C Munoz-Villafranca, C Lorente, R Rivero, M Iglesias, E Herreros, B Busquets, D Riera, J Martinez-Montiel, MP Roldon, M Roncero, O Hinojosa, E Sierra, M Barrio, J De Francisco, R Huguet, J Merino, O Carpio, D Ginard, D Munoz, F Marta, P Almela, P Argueelles-Arias, F Alcain, G Luis, B Mancenido, N Lucendo, AJ Varela, P Rodriguez-Lago, I Ramos, L Laura, S Sese, E Acosta, MBD Domenech, E Frances, R |
| author |
Gutierrez, A |
| author_facet |
Gutierrez, A Zapater, P Ricart, E Gonzalez-Vivo, M Gordillo, J Olivares, D Vera, I Manosa, M Gisbert, JP Aguas, M Sanchez-Rodriguez, E Bosca-Watts, M Laredo, V Camps, B Marin-Jimenez, I Zabana, Y Martin-Arranz, MD Munoz, R Navarro, M Sierra, E Madero, L Vela, M Perez-Calle, JL Sainz, E Calvet, X Arias, L Morales, V Bermejo, F Fernandez-Salazar, L Van Domselaar, M De Castro, L Rodriguez, C Munoz-Villafranca, C Lorente, R Rivero, M Iglesias, E Herreros, B Busquets, D Riera, J Martinez-Montiel, MP Roldon, M Roncero, O Hinojosa, E Sierra, M Barrio, J De Francisco, R Huguet, J Merino, O Carpio, D Ginard, D Munoz, F Marta, P Almela, P Argueelles-Arias, F Alcain, G Luis, B Mancenido, N Lucendo, AJ Varela, P Rodriguez-Lago, I Ramos, L Laura, S Sese, E Acosta, MBD Domenech, E Frances, R |
| author_role |
author |
| author2 |
Zapater, P Ricart, E Gonzalez-Vivo, M Gordillo, J Olivares, D Vera, I Manosa, M Gisbert, JP Aguas, M Sanchez-Rodriguez, E Bosca-Watts, M Laredo, V Camps, B Marin-Jimenez, I Zabana, Y Martin-Arranz, MD Munoz, R Navarro, M Sierra, E Madero, L Vela, M Perez-Calle, JL Sainz, E Calvet, X Arias, L Morales, V Bermejo, F Fernandez-Salazar, L Van Domselaar, M De Castro, L Rodriguez, C Munoz-Villafranca, C Lorente, R Rivero, M Iglesias, E Herreros, B Busquets, D Riera, J Martinez-Montiel, MP Roldon, M Roncero, O Hinojosa, E Sierra, M Barrio, J De Francisco, R Huguet, J Merino, O Carpio, D Ginard, D Munoz, F Marta, P Almela, P Argueelles-Arias, F Alcain, G Luis, B Mancenido, N Lucendo, AJ Varela, P Rodriguez-Lago, I Ramos, L Laura, S Sese, E Acosta, MBD Domenech, E Frances, R |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
immigrant phenotype biologics inflammatory bowel disease Crohn's disease ulcerative colitis |
| topic |
immigrant phenotype biologics inflammatory bowel disease Crohn's disease ulcerative colitis |
| description |
BackgroundPrevious studies comparing immigrant ethnic groups and native patients with IBD have yielded clinical and phenotypic differences. To date, no study has focused on the immigrant IBD population in Spain. MethodsProspective, observational, multicenter study comparing cohorts of IBD patients from ENEIDA-registry who were born outside Spain with a cohort of native patients. ResultsWe included 13,524 patients (1,864 immigrant and 11,660 native). The immigrants were younger (45 +/- 12 vs. 54 +/- 16 years, p < 0.001), had been diagnosed younger (31 +/- 12 vs. 36 +/- 15 years, p < 0.001), and had a shorter disease duration (14 +/- 7 vs. 18 +/- 8 years, p < 0.001) than native patients. Family history of IBD (9 vs. 14%, p < 0.001) and smoking (30 vs. 40%, p < 0.001) were more frequent among native patients. The most prevalent ethnic groups among immigrants were Caucasian (41.5%), followed by Latin American (30.8%), Arab (18.3%), and Asian (6.7%). Extraintestinal manifestations, mainly musculoskeletal affections, were more frequent in immigrants (19 vs. 11%, p < 0.001). Use of biologics, mainly anti-TNF, was greater in immigrants (36 vs. 29%, p < 0.001). The risk of having extraintestinal manifestations [OR: 2.23 (1.92-2.58, p < 0.001)] and using biologics [OR: 1.13 (1.0-1.26, p = 0.042)] was independently associated with immigrant status in the multivariate analyses. ConclusionsCompared with native-born patients, first-generation-immigrant IBD patients in Spain were younger at disease onset and showed an increased risk of having extraintestinal manifestations and using biologics. Our study suggests a featured phenotype of immigrant IBD patients in Spain, and constitutes a new landmark in the epidemiological characterization of immigrant IBD populations in Southern Europe. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=7677 |
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https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=7677 |
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Inglés |
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Inglés |
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info:eu-repo/semantics/openAccess |
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openAccess |
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FRONTIERS MEDIA SA |
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FRONTIERS MEDIA SA |
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Frontiers in Medicine ISSN: 2296858X reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau) |
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Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau) |
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r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau |
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r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau |
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