Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients

Previous studies comparing immigrant ethnic groups and native patients with IBD have yielded clinical and phenotypic differences. To date, no study has focused on the immigrant IBD population in Spain. Prospective, observational, multicenter study comparing cohorts of IBD patients from ENEIDA-regist...

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Autores: Gutiérrez Casbas, Ana|||0000-0002-5460-4139, Zapater, Pedro, Ricart, Elena, González Vivó, María|||0000-0001-5857-3766, Gordillo, Jordi|||0000-0001-6418-0715, Olivares, David, Vera-Mendoza, Isabel, Mañosa i Ciria, Míriam|||0000-0002-9051-2581, P. Gisbert, Javier|||0000-0003-2090-3445, Aguas, Mariam|||0000-0003-4353-569X, Sánchez-Rodríguez, Eugenia, Bosca-Watts, Marta Maia|||0000-0001-7495-8797, Laredo, Viviana, Camps, Blau, Marín Jiménez, Ignacio|||0000-0001-5424-2484, Zabana, Yamile|||0000-0003-4023-8868, Martín-Arranz, María Dolores|||0000-0002-1872-0917, Muñoz, Roser, Navarro, Mercè, Sierra, Eva, Madero, Lucía, Vela, Milagros|||0000-0003-4537-9133, Pérez-Calle, José Lázaro|||0000-0002-8724-2760, Sainz, Empar, Calvet, Xavier|||0000-0002-6278-9663, Arias García, Lara, Morales, Victor, Bermejo, Fernando|||0000-0003-4610-0886, Fernández-Salazar, Luis|||0000-0002-9951-7979, Van Domselaar, Manuel|||0000-0002-9950-2216, De Castro, Luisa, Rodríguez Gutiérrez, Cristina|||0000-0003-3954-0736, Muñoz-Villafranca, Carmen|||0000-0002-8060-8889, Lorente Poyatos, Rufo|||0000-0003-0709-2932, Rivero, Montserrat|||0000-0002-5834-1559, Iglesias-Flores, Eva, Herreros Martínez, Belén, Busquets, David|||0000-0002-9385-1415, Riera, Joan, Martínez Montiel, Pilar|||0000-0002-8688-8244, Roldón, Marta, Roncero, Oscar, Hinojosa, Esther, Sierra Ausín, Mónica|||0000-0003-3342-8209, Barrio, Jesús|||0000-0001-7087-3921, de Francisco, Ruth|||0000-0001-8476-1672, Huguet, José María|||0000-0001-6486-1262, Merino, Olga|||0000-0002-1362-4475, Carpio, Daniel|||0000-0001-7929-1151, Ginard, Daniel, Muñoz, Fernando, Piqueras, Marta|||0000-0002-3874-2638, Almela, Pedro, Argüelles-Arias, Federico|||0000-0003-3646-8919, Alcaín, Guillermo, Bujanda, Luis|||0000-0002-4353-9968, Manceñido, Noemí|||0000-0002-8089-9858, Lucendo, Alfredo J.|||0000-0003-1183-1072, Varela, Pilar|||0000-0003-1737-3236, Rodríguez-Lago, Iago|||0000-0003-1133-4578, Ramos López, Laura|||0000-0001-7015-1742, Sempere, Laura, Sesé Abizanda, Eva, Barreiro de-Acosta, Manuel|||0000-0001-5915-1477, Domènech, Eugeni|||0000-0002-2315-7196, Francés, Rubén
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:256078
Acceso en línea:https://ddd.uab.cat/record/256078
https://dx.doi.org/urn:doi:10.3389/fmed.2022.823900
Access Level:acceso abierto
Palabra clave:Immigrant
Phenotype
Biologics
Inflammatory bowel disease
Crohn's disease
Ulcerative colitis
Descripción
Sumario:Previous studies comparing immigrant ethnic groups and native patients with IBD have yielded clinical and phenotypic differences. To date, no study has focused on the immigrant IBD population in Spain. Prospective, observational, multicenter study comparing cohorts of IBD patients from ENEIDA-registry who were born outside Spain with a cohort of native patients. We included 13,524 patients (1,864 immigrant and 11,660 native). The immigrants were younger (45 ± 12 vs. 54 ± 16 years, p < 0.001), had been diagnosed younger (31 ± 12 vs. 36 ± 15 years, p < 0.001), and had a shorter disease duration (14 ± 7 vs. 18 ± 8 years, p < 0.001) than native patients. Family history of IBD (9 vs. 14%, p < 0.001) and smoking (30 vs. 40%, p < 0.001) were more frequent among native patients. The most prevalent ethnic groups among immigrants were Caucasian (41.5%), followed by Latin American (30.8%), Arab (18.3%), and Asian (6.7%). Extraintestinal manifestations, mainly musculoskeletal affections, were more frequent in immigrants (19 vs. 11%, p < 0.001). Use of biologics, mainly anti-TNF, was greater in immigrants (36 vs. 29%, p < 0.001). The risk of having extraintestinal manifestations [OR: 2.23 (1.92-2.58, p < 0.001)] and using biologics [OR: 1.13 (1.0-1.26, p = 0.042)] was independently associated with immigrant status in the multivariate analyses. Compared with native-born patients, first-generation-immigrant IBD patients in Spain were younger at disease onset and showed an increased risk of having extraintestinal manifestations and using biologics. Our study suggests a featured phenotype of immigrant IBD patients in Spain, and constitutes a new landmark in the epidemiological characterization of immigrant IBD populations in Southern Europe.

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