Use of echocardiography reveals reestablishment of ventricular pumping efficiency and partial ventricular wall motion recovery upon ventricular cryoinjury in the zebrafish

The authors confirm that all data underlying the findings are fully available without restriction. All relevant data are within the paper and its Supporting Information files

Detalles Bibliográficos
Autores: González-Rosa, Juan, Guzmán-Martínez, Gabriela, Marqués, Inés Joao, Sánchez-Iranzo, Héctor, Jiménez-Borreguero, Luis Jesús, Mercader, Nadia
Tipo de recurso: artículo
Fecha de publicación:2014
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/667285
Acceso en línea:http://hdl.handle.net/10486/667285
https://dx.doi.org/10.1371/journal.pone.0115604
Access Level:acceso abierto
Palabra clave:2D-echocardiography
Ventricular
Medicina
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spelling Use of echocardiography reveals reestablishment of ventricular pumping efficiency and partial ventricular wall motion recovery upon ventricular cryoinjury in the zebrafishGonzález-Rosa, JuanGuzmán-Martínez, GabrielaMarqués, Inés JoaoSánchez-Iranzo, HéctorJiménez-Borreguero, Luis JesúsMercader, Nadia2D-echocardiographyVentricularMedicinaThe authors confirm that all data underlying the findings are fully available without restriction. All relevant data are within the paper and its Supporting Information filesAims: While zebrafish embryos are amenable to in vivo imaging, allowing the study of morphogenetic processes during development, intravital imaging of adults is hampered by their small size and loss of transparency. The use of adult zebrafish as a vertebrate model of cardiac disease and regeneration is increasing at high speed. It is therefore of great importance to establish appropriate and robust methods to measure cardiac function parameters. Methods and Results: Here we describe the use of 2D-echocardiography to study the fractional volume shortening and segmental wall motion of the ventricle. Our data show that 2D-echocardiography can be used to evaluate cardiac injury and also to study recovery of cardiac function. Interestingly, our results show that while global systolic function recovered following cardiac cryoinjury, ventricular wall motion was only partially restored. Conclusion: Cryoinjury leads to long-lasting impairment of cardiac contraction, partially mimicking the consequences of myocardial infarction in humans. Functional assessment of heart regeneration by echocardiography allows a deeper understanding of the mechanisms of cardiac regeneration and has the advantage of being easily transferable to other cardiovascular zebrafish disease modelsFunding was from the Fundación CNIC Carlos III, the Fundación ProCNIC, the Spanish Ministry of Economy and Competitiveness (Tercel and BFU2011-25297 to N.M., FPU AP2008-00546 to J.M.G.-R. and FPU12/03007 to H.S-I.), the Community of Madrid (FIBROTEAM S2010/BMD- 2321 to N.M), PIEF-GA-2012-330728 to I.J.M. and an ERC Starting grant 337703 – zebraHeart to N.M.Public Library of ScienceDepartamento de MedicinaFacultad de Medicina20142014-12-22research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/667285https://dx.doi.org/10.1371/journal.pone.0115604reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/6672852026-06-23T12:46:27Z
dc.title.none.fl_str_mv Use of echocardiography reveals reestablishment of ventricular pumping efficiency and partial ventricular wall motion recovery upon ventricular cryoinjury in the zebrafish
title Use of echocardiography reveals reestablishment of ventricular pumping efficiency and partial ventricular wall motion recovery upon ventricular cryoinjury in the zebrafish
spellingShingle Use of echocardiography reveals reestablishment of ventricular pumping efficiency and partial ventricular wall motion recovery upon ventricular cryoinjury in the zebrafish
González-Rosa, Juan
2D-echocardiography
Ventricular
Medicina
title_short Use of echocardiography reveals reestablishment of ventricular pumping efficiency and partial ventricular wall motion recovery upon ventricular cryoinjury in the zebrafish
title_full Use of echocardiography reveals reestablishment of ventricular pumping efficiency and partial ventricular wall motion recovery upon ventricular cryoinjury in the zebrafish
title_fullStr Use of echocardiography reveals reestablishment of ventricular pumping efficiency and partial ventricular wall motion recovery upon ventricular cryoinjury in the zebrafish
title_full_unstemmed Use of echocardiography reveals reestablishment of ventricular pumping efficiency and partial ventricular wall motion recovery upon ventricular cryoinjury in the zebrafish
title_sort Use of echocardiography reveals reestablishment of ventricular pumping efficiency and partial ventricular wall motion recovery upon ventricular cryoinjury in the zebrafish
dc.creator.none.fl_str_mv González-Rosa, Juan
Guzmán-Martínez, Gabriela
Marqués, Inés Joao
Sánchez-Iranzo, Héctor
Jiménez-Borreguero, Luis Jesús
Mercader, Nadia
author González-Rosa, Juan
author_facet González-Rosa, Juan
Guzmán-Martínez, Gabriela
Marqués, Inés Joao
Sánchez-Iranzo, Héctor
Jiménez-Borreguero, Luis Jesús
Mercader, Nadia
author_role author
author2 Guzmán-Martínez, Gabriela
Marqués, Inés Joao
Sánchez-Iranzo, Héctor
Jiménez-Borreguero, Luis Jesús
Mercader, Nadia
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Medicina
Facultad de Medicina
dc.subject.none.fl_str_mv 2D-echocardiography
Ventricular
Medicina
topic 2D-echocardiography
Ventricular
Medicina
description The authors confirm that all data underlying the findings are fully available without restriction. All relevant data are within the paper and its Supporting Information files
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-12-22
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/667285
https://dx.doi.org/10.1371/journal.pone.0115604
url http://hdl.handle.net/10486/667285
https://dx.doi.org/10.1371/journal.pone.0115604
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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