Polysaccharide-Based In Situ Self-Healing Hydrogels for Tissue Engineering Applications

In situ hydrogels have attracted increasing interest in recent years due to the need to develop effective and practical implantable platforms. Traditional hydrogels require surgical interventions to be implanted and are far from providing personalized medicine applications. However, in situ hydrogel...

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Autores: Maiz Fernández, Sheila, Pérez Álvarez, Leyre, Ruiz Rubio, Leire, Vilas Vilela, José Luis, Lanceros Méndez, Senentxu
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/47527
Acceso en línea:http://hdl.handle.net/10810/47527
Access Level:acceso abierto
Palabra clave:polysaccharide
self-healing
in situ hydrogels
dynamic bonds
injectability
tissue engineering
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spelling Polysaccharide-Based In Situ Self-Healing Hydrogels for Tissue Engineering ApplicationsMaiz Fernández, SheilaPérez Álvarez, LeyreRuiz Rubio, LeireVilas Vilela, José LuisLanceros Méndez, Senentxupolysaccharideself-healingin situ hydrogelsdynamic bondsinjectabilitytissue engineeringIn situ hydrogels have attracted increasing interest in recent years due to the need to develop effective and practical implantable platforms. Traditional hydrogels require surgical interventions to be implanted and are far from providing personalized medicine applications. However, in situ hydrogels offer a wide variety of advantages, such as a non-invasive nature due to their localized action or the ability to perfectly adapt to the place to be replaced regardless the size, shape or irregularities. In recent years, research has particularly focused on in situ hydrogels based on natural polysaccharides due to their promising properties such as biocompatibility, biodegradability and their ability to self-repair. This last property inspired in nature gives them the possibility of maintaining their integrity even after damage, owing to specific physical interactions or dynamic covalent bonds that provide reversible linkages. In this review, the different self-healing mechanisms, as well as the latest research on in situ self-healing hydrogels, is presented, together with the potential applications of these materials in tissue regeneration.This research was funded by the Spanish State Research Agency (AEI) and the European Regional Development Fund (ERFD) through the project PID2019-106099RB-C43/AEI/10.13039/501100011033. Spanish Ministry of Economy and Competitiveness (MINECO) through the project MAT2016-76039-C4-3-R (AEI/FEDER, UE) and from the Basque Government Industry and Education Department under the ELKARTEK (KK-2020/00068, KK-2020/00099, KK2019/00039 and KK2019/00101), HAZITEK and PIBA (PIBA-2018-06) programs, respectively.MDPI2020202020202020info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/47527reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoInglésinfo:eu-repo/grantAgreement/MINECO/MAT2016-76039-C4-3-R/https://www.mdpi.com/2073-4360/12/10/2261/htminfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/es/2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).oai:addi.ehu.eus:10810/475272026-06-18T09:23:17Z
dc.title.none.fl_str_mv Polysaccharide-Based In Situ Self-Healing Hydrogels for Tissue Engineering Applications
title Polysaccharide-Based In Situ Self-Healing Hydrogels for Tissue Engineering Applications
spellingShingle Polysaccharide-Based In Situ Self-Healing Hydrogels for Tissue Engineering Applications
Maiz Fernández, Sheila
polysaccharide
self-healing
in situ hydrogels
dynamic bonds
injectability
tissue engineering
title_short Polysaccharide-Based In Situ Self-Healing Hydrogels for Tissue Engineering Applications
title_full Polysaccharide-Based In Situ Self-Healing Hydrogels for Tissue Engineering Applications
title_fullStr Polysaccharide-Based In Situ Self-Healing Hydrogels for Tissue Engineering Applications
title_full_unstemmed Polysaccharide-Based In Situ Self-Healing Hydrogels for Tissue Engineering Applications
title_sort Polysaccharide-Based In Situ Self-Healing Hydrogels for Tissue Engineering Applications
dc.creator.none.fl_str_mv Maiz Fernández, Sheila
Pérez Álvarez, Leyre
Ruiz Rubio, Leire
Vilas Vilela, José Luis
Lanceros Méndez, Senentxu
author Maiz Fernández, Sheila
author_facet Maiz Fernández, Sheila
Pérez Álvarez, Leyre
Ruiz Rubio, Leire
Vilas Vilela, José Luis
Lanceros Méndez, Senentxu
author_role author
author2 Pérez Álvarez, Leyre
Ruiz Rubio, Leire
Vilas Vilela, José Luis
Lanceros Méndez, Senentxu
author2_role author
author
author
author
dc.subject.none.fl_str_mv polysaccharide
self-healing
in situ hydrogels
dynamic bonds
injectability
tissue engineering
topic polysaccharide
self-healing
in situ hydrogels
dynamic bonds
injectability
tissue engineering
description In situ hydrogels have attracted increasing interest in recent years due to the need to develop effective and practical implantable platforms. Traditional hydrogels require surgical interventions to be implanted and are far from providing personalized medicine applications. However, in situ hydrogels offer a wide variety of advantages, such as a non-invasive nature due to their localized action or the ability to perfectly adapt to the place to be replaced regardless the size, shape or irregularities. In recent years, research has particularly focused on in situ hydrogels based on natural polysaccharides due to their promising properties such as biocompatibility, biodegradability and their ability to self-repair. This last property inspired in nature gives them the possibility of maintaining their integrity even after damage, owing to specific physical interactions or dynamic covalent bonds that provide reversible linkages. In this review, the different self-healing mechanisms, as well as the latest research on in situ self-healing hydrogels, is presented, together with the potential applications of these materials in tissue regeneration.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/47527
url http://hdl.handle.net/10810/47527
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/MINECO/MAT2016-76039-C4-3-R/
https://www.mdpi.com/2073-4360/12/10/2261/htm
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/3.0/es/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
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