Chaperone-mediated autophagy regulates adipocyte differentiation

Adipogenesis is a tightly orchestrated multistep process wherein preadipocytes differentiate into adipocytes. The most studied aspect of adipogenesis is its transcriptional regulation through timely expression and silencing of a vast number of genes. However, whether turnover of key regulatory prote...

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Detalles Bibliográficos
Autores: Macho González, Adrián, Kaushik, Susmita, Juste, Yves, Lindenau, Kristen, Dong, Suxhian, Santiago-Fernández, Olaya, McCabe, Mericka, Singh, Rajat, Gavathiotis, Evris, Cuervo, Ana María
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/116187
Acceso en línea:https://hdl.handle.net/20.500.14352/116187
Access Level:acceso abierto
Palabra clave:577.1
612.015
Autophagy
Bioquímica (Farmacia)
2403 Bioquímica
id ES_3cf5d4519a5b9f10bdca7da2d445b0cf
oai_identifier_str oai:docta.ucm.es:20.500.14352/116187
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repository_id_str
spelling Chaperone-mediated autophagy regulates adipocyte differentiationMacho González, AdriánKaushik, SusmitaJuste, YvesLindenau, KristenDong, SuxhianSantiago-Fernández, OlayaMcCabe, MerickaSingh, RajatGavathiotis, EvrisCuervo, Ana María577.1612.015AutophagyBioquímica (Farmacia)2403 BioquímicaAdipogenesis is a tightly orchestrated multistep process wherein preadipocytes differentiate into adipocytes. The most studied aspect of adipogenesis is its transcriptional regulation through timely expression and silencing of a vast number of genes. However, whether turnover of key regulatory proteins per se controls adipogenesis remains largely understudied. Chaperone-mediated autophagy (CMA) is a selective form of lysosomal protein degradation that, in response to diverse cues, remodels the proteome for regulatory purposes. We report here the activation of CMA during adipocyte differentiation and show that CMA regulates adipogenesis at different steps through timely degradation of key regulatory signaling proteins and transcription factors that dictate proliferation, energetic adaptation, and signaling changes required for adipogenesis.ScienceUniversidad Complutense de Madrid20222022-01-0120222022-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/116187reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1161872026-06-02T12:44:21Z
dc.title.none.fl_str_mv Chaperone-mediated autophagy regulates adipocyte differentiation
title Chaperone-mediated autophagy regulates adipocyte differentiation
spellingShingle Chaperone-mediated autophagy regulates adipocyte differentiation
Macho González, Adrián
577.1
612.015
Autophagy
Bioquímica (Farmacia)
2403 Bioquímica
title_short Chaperone-mediated autophagy regulates adipocyte differentiation
title_full Chaperone-mediated autophagy regulates adipocyte differentiation
title_fullStr Chaperone-mediated autophagy regulates adipocyte differentiation
title_full_unstemmed Chaperone-mediated autophagy regulates adipocyte differentiation
title_sort Chaperone-mediated autophagy regulates adipocyte differentiation
dc.creator.none.fl_str_mv Macho González, Adrián
Kaushik, Susmita
Juste, Yves
Lindenau, Kristen
Dong, Suxhian
Santiago-Fernández, Olaya
McCabe, Mericka
Singh, Rajat
Gavathiotis, Evris
Cuervo, Ana María
author Macho González, Adrián
author_facet Macho González, Adrián
Kaushik, Susmita
Juste, Yves
Lindenau, Kristen
Dong, Suxhian
Santiago-Fernández, Olaya
McCabe, Mericka
Singh, Rajat
Gavathiotis, Evris
Cuervo, Ana María
author_role author
author2 Kaushik, Susmita
Juste, Yves
Lindenau, Kristen
Dong, Suxhian
Santiago-Fernández, Olaya
McCabe, Mericka
Singh, Rajat
Gavathiotis, Evris
Cuervo, Ana María
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 577.1
612.015
Autophagy
Bioquímica (Farmacia)
2403 Bioquímica
topic 577.1
612.015
Autophagy
Bioquímica (Farmacia)
2403 Bioquímica
description Adipogenesis is a tightly orchestrated multistep process wherein preadipocytes differentiate into adipocytes. The most studied aspect of adipogenesis is its transcriptional regulation through timely expression and silencing of a vast number of genes. However, whether turnover of key regulatory proteins per se controls adipogenesis remains largely understudied. Chaperone-mediated autophagy (CMA) is a selective form of lysosomal protein degradation that, in response to diverse cues, remodels the proteome for regulatory purposes. We report here the activation of CMA during adipocyte differentiation and show that CMA regulates adipogenesis at different steps through timely degradation of key regulatory signaling proteins and transcription factors that dictate proliferation, energetic adaptation, and signaling changes required for adipogenesis.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-01-01
2022
2022-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/116187
url https://hdl.handle.net/20.500.14352/116187
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Science
publisher.none.fl_str_mv Science
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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