Preventive Effects of an var. Extract on Lipid Metabolism in a High-Fat High-Fructose Diet-Induced Obesity Animal Model

Due to the continuous global rise in obesity prevalence, foods rich in bioactive compounds are increasingly recognised for the management of several diseases. The present study aims to investigate whether an var. fruit peel extract, rich in betalains and phenolic compounds, is able to prevent obesit...

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Authors: Gómez-García, Iker, Fernández-Quintela, Alfredo, Oliver, Paula, Picó, Catalina, Cano, M Pilar, Portillo, María P, Trepiana, Jenifer
Format: article
Publication Date:2025
Country:España
Institution:Conselleria de Salut i Consum del Govern de les Illes Balears
Repository:Docusalut
Language:English
OAI Identifier:oai:docusalut.com:20.500.13003/26123
Online Access:https://hdl.handle.net/20.500.13003/26123
Access Level:Open access
Keyword:Opuntia
Adipose Tissue
Betalains
Fructose
Diet, High-Fat
Obesity
Phenolic Compounds
Tejido Adiposo
Betalaínas
Fructosa
Dieta Alta en Grasa
Obesidad
Compuestos Fenólicos
Opuntia stricta var. dillenii
adipose tissue
betalains
high-fat high-fructose diet
obesity
phenolic compounds
prickly pear
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spelling Preventive Effects of an var. Extract on Lipid Metabolism in a High-Fat High-Fructose Diet-Induced Obesity Animal ModelGómez-García, IkerFernández-Quintela, AlfredoOliver, PaulaPicó, CatalinaCano, M PilarPortillo, María PTrepiana, JeniferOpuntiaAdipose TissueBetalainsFructoseDiet, High-FatObesityPhenolic CompoundsOpuntiaTejido AdiposoBetalaínasFructosaDieta Alta en GrasaObesidadCompuestos FenólicosOpuntia stricta var. dilleniiadipose tissuebetalainshigh-fat high-fructose dietobesityphenolic compoundsprickly pearDue to the continuous global rise in obesity prevalence, foods rich in bioactive compounds are increasingly recognised for the management of several diseases. The present study aims to investigate whether an var. fruit peel extract, rich in betalains and phenolic compounds, is able to prevent obesity induced by a high-fat high-fructose diet in rats, along with the potential mechanisms of action underlying this effect. The supplementation with var. extract obtained from the peel fruit partially prevents obesity development by attenuating HFHF-induced fat accumulation. This effect was observed predominantly in visceral adipose tissue, rather than in the subcutaneous depot. The obesity prevention was accompanied by the improvement of serum lipid profile. The mechanisms underlying the extract anti-obesity effect which were analysed in epididymal adipose tissue, involve preventing the rise in the availability of triglyceride synthesis substrates induced by high-fat high-fructose feeding, the inhibition of triglyceride assembly, and in the case of the high dose, increased lipolysis. According to these results, the peel wastes of var. fruit represent a promising natural source of bioactive compounds for obesity prevention. Nevertheless, these preclinical effects should be replicated in further studies in human beings.MDPI20252025-01-0120252025-01-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.13003/26123reponame:Docusalutinstname:Conselleria de Salut i Consum del Govern de les Illes BalearsInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docusalut.com:20.500.13003/261232026-06-22T12:44:07Z
dc.title.none.fl_str_mv Preventive Effects of an var. Extract on Lipid Metabolism in a High-Fat High-Fructose Diet-Induced Obesity Animal Model
title Preventive Effects of an var. Extract on Lipid Metabolism in a High-Fat High-Fructose Diet-Induced Obesity Animal Model
spellingShingle Preventive Effects of an var. Extract on Lipid Metabolism in a High-Fat High-Fructose Diet-Induced Obesity Animal Model
Gómez-García, Iker
Opuntia
Adipose Tissue
Betalains
Fructose
Diet, High-Fat
Obesity
Phenolic Compounds
Opuntia
Tejido Adiposo
Betalaínas
Fructosa
Dieta Alta en Grasa
Obesidad
Compuestos Fenólicos
Opuntia stricta var. dillenii
adipose tissue
betalains
high-fat high-fructose diet
obesity
phenolic compounds
prickly pear
title_short Preventive Effects of an var. Extract on Lipid Metabolism in a High-Fat High-Fructose Diet-Induced Obesity Animal Model
title_full Preventive Effects of an var. Extract on Lipid Metabolism in a High-Fat High-Fructose Diet-Induced Obesity Animal Model
title_fullStr Preventive Effects of an var. Extract on Lipid Metabolism in a High-Fat High-Fructose Diet-Induced Obesity Animal Model
title_full_unstemmed Preventive Effects of an var. Extract on Lipid Metabolism in a High-Fat High-Fructose Diet-Induced Obesity Animal Model
title_sort Preventive Effects of an var. Extract on Lipid Metabolism in a High-Fat High-Fructose Diet-Induced Obesity Animal Model
dc.creator.none.fl_str_mv Gómez-García, Iker
Fernández-Quintela, Alfredo
Oliver, Paula
Picó, Catalina
Cano, M Pilar
Portillo, María P
Trepiana, Jenifer
author Gómez-García, Iker
author_facet Gómez-García, Iker
Fernández-Quintela, Alfredo
Oliver, Paula
Picó, Catalina
Cano, M Pilar
Portillo, María P
Trepiana, Jenifer
author_role author
author2 Fernández-Quintela, Alfredo
Oliver, Paula
Picó, Catalina
Cano, M Pilar
Portillo, María P
Trepiana, Jenifer
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Opuntia
Adipose Tissue
Betalains
Fructose
Diet, High-Fat
Obesity
Phenolic Compounds
Opuntia
Tejido Adiposo
Betalaínas
Fructosa
Dieta Alta en Grasa
Obesidad
Compuestos Fenólicos
Opuntia stricta var. dillenii
adipose tissue
betalains
high-fat high-fructose diet
obesity
phenolic compounds
prickly pear
topic Opuntia
Adipose Tissue
Betalains
Fructose
Diet, High-Fat
Obesity
Phenolic Compounds
Opuntia
Tejido Adiposo
Betalaínas
Fructosa
Dieta Alta en Grasa
Obesidad
Compuestos Fenólicos
Opuntia stricta var. dillenii
adipose tissue
betalains
high-fat high-fructose diet
obesity
phenolic compounds
prickly pear
description Due to the continuous global rise in obesity prevalence, foods rich in bioactive compounds are increasingly recognised for the management of several diseases. The present study aims to investigate whether an var. fruit peel extract, rich in betalains and phenolic compounds, is able to prevent obesity induced by a high-fat high-fructose diet in rats, along with the potential mechanisms of action underlying this effect. The supplementation with var. extract obtained from the peel fruit partially prevents obesity development by attenuating HFHF-induced fat accumulation. This effect was observed predominantly in visceral adipose tissue, rather than in the subcutaneous depot. The obesity prevention was accompanied by the improvement of serum lipid profile. The mechanisms underlying the extract anti-obesity effect which were analysed in epididymal adipose tissue, involve preventing the rise in the availability of triglyceride synthesis substrates induced by high-fat high-fructose feeding, the inhibition of triglyceride assembly, and in the case of the high dose, increased lipolysis. According to these results, the peel wastes of var. fruit represent a promising natural source of bioactive compounds for obesity prevention. Nevertheless, these preclinical effects should be replicated in further studies in human beings.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-01-01
2025
2025-01-01
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.13003/26123
url https://hdl.handle.net/20.500.13003/26123
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docusalut
instname:Conselleria de Salut i Consum del Govern de les Illes Balears
instname_str Conselleria de Salut i Consum del Govern de les Illes Balears
reponame_str Docusalut
collection Docusalut
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869406401157136384
score 15,81155

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