Preventive Effects of an var. Extract on Lipid Metabolism in a High-Fat High-Fructose Diet-Induced Obesity Animal Model
Due to the continuous global rise in obesity prevalence, foods rich in bioactive compounds are increasingly recognised for the management of several diseases. The present study aims to investigate whether an var. fruit peel extract, rich in betalains and phenolic compounds, is able to prevent obesit...
| Autores: | , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Conselleria de Salut i Consum del Govern de les Illes Balears |
| Repositorio: | Docusalut |
| Idioma: | inglés |
| OAI Identifier: | oai:docusalut.com:20.500.13003/26123 |
| Acceso en línea: | https://hdl.handle.net/20.500.13003/26123 |
| Access Level: | acceso abierto |
| Palabra clave: | Opuntia Adipose Tissue Betalains Fructose Diet, High-Fat Obesity Phenolic Compounds Tejido Adiposo Betalaínas Fructosa Dieta Alta en Grasa Obesidad Compuestos Fenólicos Opuntia stricta var. dillenii adipose tissue betalains high-fat high-fructose diet obesity phenolic compounds prickly pear |
| Sumario: | Due to the continuous global rise in obesity prevalence, foods rich in bioactive compounds are increasingly recognised for the management of several diseases. The present study aims to investigate whether an var. fruit peel extract, rich in betalains and phenolic compounds, is able to prevent obesity induced by a high-fat high-fructose diet in rats, along with the potential mechanisms of action underlying this effect. The supplementation with var. extract obtained from the peel fruit partially prevents obesity development by attenuating HFHF-induced fat accumulation. This effect was observed predominantly in visceral adipose tissue, rather than in the subcutaneous depot. The obesity prevention was accompanied by the improvement of serum lipid profile. The mechanisms underlying the extract anti-obesity effect which were analysed in epididymal adipose tissue, involve preventing the rise in the availability of triglyceride synthesis substrates induced by high-fat high-fructose feeding, the inhibition of triglyceride assembly, and in the case of the high dose, increased lipolysis. According to these results, the peel wastes of var. fruit represent a promising natural source of bioactive compounds for obesity prevention. Nevertheless, these preclinical effects should be replicated in further studies in human beings. |
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