Additional file 3 of Aβ oligomers trigger necroptosis-mediated neurodegeneration via microglia activation in Alzheimer’s disease
Additional file 3: Fig. S3. Validation of the pMLKL antibody and assessment of cell specificity. Representative micrographs of (A) the dentate gyrus (DG) and (B) CA1 brain regions from wild-type and MLKL knockout mice subjected to intracerebral injection of Aβo, immunostained with anti-pMLKL antibod...
| Autores: | , , , , , , , , , , |
|---|---|
| Tipo de recurso: | conjunto de datos |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/331097 |
| Acceso en línea: | http://hdl.handle.net/10261/331097 |
| Access Level: | acceso abierto |
| Palabra clave: | Alzheimer’s disease Amyloid-β oligomers Necroptosis Microglia Neurodegeneration Neuroprotection |
| Sumario: | Additional file 3: Fig. S3. Validation of the pMLKL antibody and assessment of cell specificity. Representative micrographs of (A) the dentate gyrus (DG) and (B) CA1 brain regions from wild-type and MLKL knockout mice subjected to intracerebral injection of Aβo, immunostained with anti-pMLKL antibody (scale bar, DG: 100 μm, CA1: 150 μm). (C, D) Representative images of the hilus of wild-type mice treated with Aβo, labeled with the indicated antibodies (scale bar, 50 μm and 25 μm for magnifications). |
|---|