Booster Effect of a Natural Extract of Polypodium leucotomos (Fernblock®) That Improves the UV Barrier Function and Immune Protection Capability of Sunscreen Formulations

© 2021 Aguilera, Vicente-Manzanares, de Gálvez, Herrera-Ceballos, Rodríguez-Luna and González.

Detalles Bibliográficos
Autores: Aguilera, Jose, Vicente-Manzanares, Miguel, Gálvez, María Victoria de, Herrera-Ceballos, Enrique, Rodríguez-Luna, Azahara, González, Salvador
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/261074
Acceso en línea:http://hdl.handle.net/10261/261074
Access Level:acceso abierto
Palabra clave:Ultraviolet radiation
Sunscreens
Polypodium leucotomos extract
Booster effect
Human immunoprotection factor
Sun protection factor
UVA protection factor
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spelling Booster Effect of a Natural Extract of Polypodium leucotomos (Fernblock®) That Improves the UV Barrier Function and Immune Protection Capability of Sunscreen FormulationsAguilera, JoseVicente-Manzanares, MiguelGálvez, María Victoria deHerrera-Ceballos, EnriqueRodríguez-Luna, AzaharaGonzález, SalvadorUltraviolet radiationSunscreensPolypodium leucotomos extractBooster effectHuman immunoprotection factorSun protection factorUVA protection factor© 2021 Aguilera, Vicente-Manzanares, de Gálvez, Herrera-Ceballos, Rodríguez-Luna and González.[Background]: Novel approaches to photoprotection must go beyond classical MED measurements, as discoveries on the effect of UV radiation on skin paints a more complex and multi-pronged scenario with multitude of skin cell types involved. Of these, photoimmunoprotection emerges as a crucial factor that protects against skin cancer and photoaging. A novel immune parameter is enabled by the precise knowledge of the wavelength and dose of solar radiation that induces photoimmunosupression. Natural substances, that can play different roles in photoprotection as antioxidant, immune regulation, and DNA protection as well as its possible ability as sunscreen are the new goals in cosmetic industry.[Objective]: To analyze the effect of a specific natural extract from Polypodium leucotomos (PLE, Fernblock®), as part of topical sunscreen formulations to protect from photoimmunosuppression, as well as other deleterious biological effects of UV radiation.[Methods]: The possible sunscreen effect of PLE was analyzed by including 1% (w/w) PLE in four different galenic formulations containing different combinations of UVB and UVA organic and mineral filters. In vitro sun protection factor (SPF), UVA protection factor (UVA-PF), contact hypersensitivity factor (CHS), and human immunoprotection factor (HIF) were estimated following the same protocol as ISO 24443:2012 for in vitro UVA-PF determination.[Results]: PLE-containing formulations significantly reduced UV radiation reaching to skin. Combination of UVB and UVA filters with PLE increased SPF and UVAPF significantly. PLE also increased UV immune protection, by elevating the contact hypersensitivity factor and the human immunoprotective factor of the sunscreen formulations. [Conclusion]: This study confirms the double role of PLE in photoprotection. Together to the biological activity shown in previous works, the UV absorption properties of PLE confers a booster effect when it is supplemented in topical sunscreens increasing the protection not only at level of erythema and permanent pigment darkening but also against two photoimmunoprotection factors.This research was funded by Cantabria Labs.Frontiers MediaCantabria LabsConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2022202220212022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/261074reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.3389/fmed.2021.684665Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2610742026-05-22T06:33:51Z
dc.title.none.fl_str_mv Booster Effect of a Natural Extract of Polypodium leucotomos (Fernblock®) That Improves the UV Barrier Function and Immune Protection Capability of Sunscreen Formulations
title Booster Effect of a Natural Extract of Polypodium leucotomos (Fernblock®) That Improves the UV Barrier Function and Immune Protection Capability of Sunscreen Formulations
spellingShingle Booster Effect of a Natural Extract of Polypodium leucotomos (Fernblock®) That Improves the UV Barrier Function and Immune Protection Capability of Sunscreen Formulations
Aguilera, Jose
Ultraviolet radiation
Sunscreens
Polypodium leucotomos extract
Booster effect
Human immunoprotection factor
Sun protection factor
UVA protection factor
title_short Booster Effect of a Natural Extract of Polypodium leucotomos (Fernblock®) That Improves the UV Barrier Function and Immune Protection Capability of Sunscreen Formulations
title_full Booster Effect of a Natural Extract of Polypodium leucotomos (Fernblock®) That Improves the UV Barrier Function and Immune Protection Capability of Sunscreen Formulations
title_fullStr Booster Effect of a Natural Extract of Polypodium leucotomos (Fernblock®) That Improves the UV Barrier Function and Immune Protection Capability of Sunscreen Formulations
title_full_unstemmed Booster Effect of a Natural Extract of Polypodium leucotomos (Fernblock®) That Improves the UV Barrier Function and Immune Protection Capability of Sunscreen Formulations
title_sort Booster Effect of a Natural Extract of Polypodium leucotomos (Fernblock®) That Improves the UV Barrier Function and Immune Protection Capability of Sunscreen Formulations
dc.creator.none.fl_str_mv Aguilera, Jose
Vicente-Manzanares, Miguel
Gálvez, María Victoria de
Herrera-Ceballos, Enrique
Rodríguez-Luna, Azahara
González, Salvador
author Aguilera, Jose
author_facet Aguilera, Jose
Vicente-Manzanares, Miguel
Gálvez, María Victoria de
Herrera-Ceballos, Enrique
Rodríguez-Luna, Azahara
González, Salvador
author_role author
author2 Vicente-Manzanares, Miguel
Gálvez, María Victoria de
Herrera-Ceballos, Enrique
Rodríguez-Luna, Azahara
González, Salvador
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Cantabria Labs
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Ultraviolet radiation
Sunscreens
Polypodium leucotomos extract
Booster effect
Human immunoprotection factor
Sun protection factor
UVA protection factor
topic Ultraviolet radiation
Sunscreens
Polypodium leucotomos extract
Booster effect
Human immunoprotection factor
Sun protection factor
UVA protection factor
description © 2021 Aguilera, Vicente-Manzanares, de Gálvez, Herrera-Ceballos, Rodríguez-Luna and González.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/261074
url http://hdl.handle.net/10261/261074
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.3389/fmed.2021.684665
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869406352619601920
score 15.81155

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