Protective Effect of the Hydrophilic Extract of Polypodium leucotomos, Fernblock®, against the Synergistic Action of UVA Radiation and Benzo[a]pyrene Pollutant
Oxidative stress is a harmful effect induced on the skin by polycyclic aromatic hydrocarbons Citation: Gallego-Rentero, M.; Nicolás-Morala, J.; Alonso-Juarranz, M.; Carrasco, E.; Portillo-Esnaola, M.; Rodríguez-Luna, A.; González, S. Protective Effect of the Hydrophilic Extract of Polypodium leucoto...
| Autores: | , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universidad Autónoma de Madrid |
| Repositorio: | Biblos-e Archivo. Repositorio Institucional de la UAM |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.uam.es:10486/706354 |
| Acceso en línea: | http://hdl.handle.net/10486/706354 https://dx.doi.org/10.3390/antiox11112185 |
| Access Level: | acceso abierto |
| Palabra clave: | photopollution benzo[a]pyrene ultraviolet A radiation oxidative stress Polypodium leucotomos photoprotection keratinocytes melanocytes Biología y Biomedicina / Biología |
| Sumario: | Oxidative stress is a harmful effect induced on the skin by polycyclic aromatic hydrocarbons Citation: Gallego-Rentero, M.; Nicolás-Morala, J.; Alonso-Juarranz, M.; Carrasco, E.; Portillo-Esnaola, M.; Rodríguez-Luna, A.; González, S. Protective Effect of the Hydrophilic Extract of Polypodium leucotomos, Fernblock®, against the Synergistic Action of UVA Radiation and Benzo[a]pyrene Pollutant. Antioxidants 2022, 11, 2185. https://doi.org/10.3390/ antiox11112185 Academic Editor: Stanley Omaye Received: 8 October 2022 Accepted: 28 October 2022 Published: 4 November 2022 Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). (PAH), including benzo[a]pyrene (BaP) air pollutants. This effect is amplified by the additive damaging effect of the sun, especially through the UVA light component. Besides being one of the main compounds that make up air pollution, BaP can also be found in tar, tobacco smoke, and various foods. In addition to its direct carcinogenic potential, BaP can act as a photosensitizer absorbing sunlight in the UVA range and thus generating ROS and 8-hydroxy-2-deoxyguanosine (8-OHdG). Fernblock® (FB) is an aqueous extract from the leaves of Polypodium leucotomos that has been proven to exert photoprotective and antioxidant effects on skin cells. In this study, we evaluate the potential of FB to prevent the damage induced by a combination of BaP and UVA light on human keratinocyte and mouse melanocyte cell lines (HaCaT and B16-F10, respectively). In particular, we have analyzed the capacity of FB to counteract the alterations caused on cellular morphology, viability, oxidative stress and melanogenic signaling pathway activation. Our data indicate that FB prevented cell damage and reduced oxidative stress and melanogenic signaling pathway activation caused by a combination of BaP and UVAlightirradiation. Altogether, our findings support the fact that FB is able to prevent skin damage caused by the exposure to a combination of UVA and the air pollutant BaP |
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