Dopamine Pathway and Parkinson's Risk Variants Are Associated with Levodopa-Induced Dyskinesia

[Background] Levodopa-induced dyskinesia (LID) is a common adverse effect of levodopa, one of the main therapeutics used to treat the motor symptoms of Parkinson's disease (PD). Previous evidence suggests a connection between LID and a disruption of the dopaminergic system as well as genes impl...

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Detalhes bibliográficos
Autores: Sosero, Yuri L., Bandres-Ciga, Sara, Ferwerda, Bart, Tocino, Maria T. P., Díaz-Belloso, Rafael, Gómez-Garre, Pilar, Faouzi, Johann, Taba, Pille, Pavelka, Lukas, Marques, Tainà M., Gomes, Clarissa P. C., Kolodkin, Alexey, May, Patrick, Milanowski, Lukasz M., Wszolek, Zbigniew K., Uitti, Ryan J., Heutink, Peter, van Hilten, Jacobus J., Simon, David K., Eberly, Shirley, Álvarez, Ignacio, Krohn, Lynne, Yu, Eric, Freeman, Kathryn, Rudakou, Uladzislau, Ruskey, Jennifer A., Asayesh, Farnaz, Menéndez-González, Manuel, Pastor, Pau, Ross, Owen A., Krüger, Rejko, Corvol, Jean-Christophe, Koks, Sulev, Mir, Pablo, De Bie, Rob M. A., Iwaki, Hirotaka, Gan-Or, Ziv
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/385691
Acesso em linha:http://hdl.handle.net/10261/385691
https://api.elsevier.com/content/abstract/scopus_id/85201301987
Access Level:acceso abierto
Palavra-chave:Levodopa‐induced dyskinesia
GBA1
LRRK2
Parkinson's disease
Dopamine
Descrição
Resumo:[Background] Levodopa-induced dyskinesia (LID) is a common adverse effect of levodopa, one of the main therapeutics used to treat the motor symptoms of Parkinson's disease (PD). Previous evidence suggests a connection between LID and a disruption of the dopaminergic system as well as genes implicated in PD, including GBA1 and LRRK2.

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