Longer telomeres are associated with cancer risk in MMR-proficient hereditary non-polyposis colorectal cancer

Aberrant telomere length measured in blood has been associated with increased risk of several cancer types. In the field of hereditary non-polyposis colorectal cancer (CRC), and more particularly in Lynch syndrome, caused by germline mutations in the mismatch repair (MMR) genes, we recently found th...

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Autores: Seguí Gracia, Nuria, Guinó, Elisabet, Pineda Riu, Marta, Navarro, Matilde, Bellido Molías, Fernando, Lázaro García, Conxi, Blanco Guillermo, Ignacio, Moreno Aguado, Víctor, Capellá, G. (Gabriel), Valle Velasco, Laura
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/103197
Acceso en línea:https://hdl.handle.net/2445/103197
Access Level:acceso abierto
Palabra clave:Telòmer
ADN
Genètica humana
Càncer colorectal
Malalties hereditàries
Factors de risc en les malalties
Telomere
DNA
Human genetics
Colorectal cancer
Genetic diseases
Risk factors in diseases
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repository_id_str
spelling Longer telomeres are associated with cancer risk in MMR-proficient hereditary non-polyposis colorectal cancerSeguí Gracia, NuriaGuinó, ElisabetPineda Riu, MartaNavarro, MatildeBellido Molías, FernandoLázaro García, ConxiBlanco Guillermo, IgnacioMoreno Aguado, VíctorCapellá, G. (Gabriel)Valle Velasco, LauraTelòmerADNGenètica humanaCàncer colorectalMalalties hereditàriesFactors de risc en les malaltiesTelomereDNAHuman geneticsColorectal cancerGenetic diseasesRisk factors in diseasesAberrant telomere length measured in blood has been associated with increased risk of several cancer types. In the field of hereditary non-polyposis colorectal cancer (CRC), and more particularly in Lynch syndrome, caused by germline mutations in the mismatch repair (MMR) genes, we recently found that cancer-affected MMR gene mutation carriers had shorter telomeres and more pronounced shortening of telomere length with age than controls and unaffected MMR gene mutation carriers. Here we evaluate blood telomere length in MMR-proficient hereditary non-polyposis CRC, i.e. familial CRC type X (fCRC-X). A total of 57 cancer-affected and 57 cancer-free individuals from 34 Amsterdam-positive fCRC-X families were analyzed and compared to the data previously published on 144 cancer-affected and 100 cancer-free MMR gene mutation carriers, and 234 controls. Relative telomere length was measured using a monochrome multiplex quantitative PCR method, following strict measures to avoid sources of bias and adjusting by age. Despite the retrospective nature of our study, the results show that longer telomeres associate with cancer risk in fCRC-X, thus identifying different patterns of telomere length according to the status of the MMR system.Public Library of Science (PLoS)2014info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/103197Articles publicats en revistes (Ciències Clíniques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1371/journal.pone.0086063PLoS One, 2014, vol. 9, num. 2, p. e86063https://doi.org/10.1371/journal.pone.0086063cc-by (c) Seguí Gracia, Nuria et al., 2014http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1031972026-05-27T06:46:51Z
dc.title.none.fl_str_mv Longer telomeres are associated with cancer risk in MMR-proficient hereditary non-polyposis colorectal cancer
title Longer telomeres are associated with cancer risk in MMR-proficient hereditary non-polyposis colorectal cancer
spellingShingle Longer telomeres are associated with cancer risk in MMR-proficient hereditary non-polyposis colorectal cancer
Seguí Gracia, Nuria
Telòmer
ADN
Genètica humana
Càncer colorectal
Malalties hereditàries
Factors de risc en les malalties
Telomere
DNA
Human genetics
Colorectal cancer
Genetic diseases
Risk factors in diseases
title_short Longer telomeres are associated with cancer risk in MMR-proficient hereditary non-polyposis colorectal cancer
title_full Longer telomeres are associated with cancer risk in MMR-proficient hereditary non-polyposis colorectal cancer
title_fullStr Longer telomeres are associated with cancer risk in MMR-proficient hereditary non-polyposis colorectal cancer
title_full_unstemmed Longer telomeres are associated with cancer risk in MMR-proficient hereditary non-polyposis colorectal cancer
title_sort Longer telomeres are associated with cancer risk in MMR-proficient hereditary non-polyposis colorectal cancer
dc.creator.none.fl_str_mv Seguí Gracia, Nuria
Guinó, Elisabet
Pineda Riu, Marta
Navarro, Matilde
Bellido Molías, Fernando
Lázaro García, Conxi
Blanco Guillermo, Ignacio
Moreno Aguado, Víctor
Capellá, G. (Gabriel)
Valle Velasco, Laura
author Seguí Gracia, Nuria
author_facet Seguí Gracia, Nuria
Guinó, Elisabet
Pineda Riu, Marta
Navarro, Matilde
Bellido Molías, Fernando
Lázaro García, Conxi
Blanco Guillermo, Ignacio
Moreno Aguado, Víctor
Capellá, G. (Gabriel)
Valle Velasco, Laura
author_role author
author2 Guinó, Elisabet
Pineda Riu, Marta
Navarro, Matilde
Bellido Molías, Fernando
Lázaro García, Conxi
Blanco Guillermo, Ignacio
Moreno Aguado, Víctor
Capellá, G. (Gabriel)
Valle Velasco, Laura
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Telòmer
ADN
Genètica humana
Càncer colorectal
Malalties hereditàries
Factors de risc en les malalties
Telomere
DNA
Human genetics
Colorectal cancer
Genetic diseases
Risk factors in diseases
topic Telòmer
ADN
Genètica humana
Càncer colorectal
Malalties hereditàries
Factors de risc en les malalties
Telomere
DNA
Human genetics
Colorectal cancer
Genetic diseases
Risk factors in diseases
description Aberrant telomere length measured in blood has been associated with increased risk of several cancer types. In the field of hereditary non-polyposis colorectal cancer (CRC), and more particularly in Lynch syndrome, caused by germline mutations in the mismatch repair (MMR) genes, we recently found that cancer-affected MMR gene mutation carriers had shorter telomeres and more pronounced shortening of telomere length with age than controls and unaffected MMR gene mutation carriers. Here we evaluate blood telomere length in MMR-proficient hereditary non-polyposis CRC, i.e. familial CRC type X (fCRC-X). A total of 57 cancer-affected and 57 cancer-free individuals from 34 Amsterdam-positive fCRC-X families were analyzed and compared to the data previously published on 144 cancer-affected and 100 cancer-free MMR gene mutation carriers, and 234 controls. Relative telomere length was measured using a monochrome multiplex quantitative PCR method, following strict measures to avoid sources of bias and adjusting by age. Despite the retrospective nature of our study, the results show that longer telomeres associate with cancer risk in fCRC-X, thus identifying different patterns of telomere length according to the status of the MMR system.
publishDate 2014
dc.date.none.fl_str_mv 2014
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/103197
url https://hdl.handle.net/2445/103197
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0086063
PLoS One, 2014, vol. 9, num. 2, p. e86063
https://doi.org/10.1371/journal.pone.0086063
dc.rights.none.fl_str_mv cc-by (c) Seguí Gracia, Nuria et al., 2014
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Seguí Gracia, Nuria et al., 2014
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300724

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