Longer telomeres are associated with cancer risk in MMR-proficient hereditary non-polyposis colorectal cancer

Aberrant telomere length measured in blood has been associated with increased risk of several cancer types. In the field of hereditary non-polyposis colorectal cancer (CRC), and more particularly in Lynch syndrome, caused by germline mutations in the mismatch repair (MMR) genes, we recently found th...

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Detalhes bibliográficos
Autores: Seguí Gracia, Nuria, Guinó, Elisabet, Pineda Riu, Marta, Navarro, Matilde, Bellido Molías, Fernando, Lázaro García, Conxi, Blanco Guillermo, Ignacio, Moreno Aguado, Víctor, Capellá, G. (Gabriel), Valle Velasco, Laura
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2014
País:España
Recursos:Universidad de Barcelona
Repositório:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/103197
Acesso em linha:https://hdl.handle.net/2445/103197
Access Level:Acceso aberto
Palavra-chave:Telòmer
ADN
Genètica humana
Càncer colorectal
Malalties hereditàries
Factors de risc en les malalties
Telomere
DNA
Human genetics
Colorectal cancer
Genetic diseases
Risk factors in diseases
Descrição
Resumo:Aberrant telomere length measured in blood has been associated with increased risk of several cancer types. In the field of hereditary non-polyposis colorectal cancer (CRC), and more particularly in Lynch syndrome, caused by germline mutations in the mismatch repair (MMR) genes, we recently found that cancer-affected MMR gene mutation carriers had shorter telomeres and more pronounced shortening of telomere length with age than controls and unaffected MMR gene mutation carriers. Here we evaluate blood telomere length in MMR-proficient hereditary non-polyposis CRC, i.e. familial CRC type X (fCRC-X). A total of 57 cancer-affected and 57 cancer-free individuals from 34 Amsterdam-positive fCRC-X families were analyzed and compared to the data previously published on 144 cancer-affected and 100 cancer-free MMR gene mutation carriers, and 234 controls. Relative telomere length was measured using a monochrome multiplex quantitative PCR method, following strict measures to avoid sources of bias and adjusting by age. Despite the retrospective nature of our study, the results show that longer telomeres associate with cancer risk in fCRC-X, thus identifying different patterns of telomere length according to the status of the MMR system.

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