Candida Periprosthetic Joint Infection

Candida periprosthetic joint infection (CPJI) is a rare and very difficult to treat infection, and high-quality evidence regarding the best management is scarce. Candida spp. adhere to medical devices and grow forming biofilms, which contribute to the persistence and relapse of this infection. Typic...

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Autores: Escolà-Vergé, Laura|||0000-0002-5608-3090, Rodriguez-Pardo, Dolors|||0000-0001-6781-5405, Corona Pérez-Cardona, Pablo S|||0000-0003-4128-3142, Pigrau, Carlos|||0000-0003-4232-4049
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:255512
Acceso en línea:https://ddd.uab.cat/record/255512
https://dx.doi.org/urn:doi:10.3390/antibiotics10040458
Access Level:acceso abierto
Palabra clave:Candida spp
Periprosthetic joint infection
Fungus
Biofilm
Antifungal-loaded cement spacer
Two-stage exchange surgery
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spelling Candida Periprosthetic Joint InfectionIs It Curable?Escolà-Vergé, Laura|||0000-0002-5608-3090Rodriguez-Pardo, Dolors|||0000-0001-6781-5405Corona Pérez-Cardona, Pablo S|||0000-0003-4128-3142Pigrau, Carlos|||0000-0003-4232-4049Candida sppPeriprosthetic joint infectionFungusBiofilmAntifungal-loaded cement spacerTwo-stage exchange surgeryCandida periprosthetic joint infection (CPJI) is a rare and very difficult to treat infection, and high-quality evidence regarding the best management is scarce. Candida spp. adhere to medical devices and grow forming biofilms, which contribute to the persistence and relapse of this infection. Typically, CPJI presents as a chronic infection in a patient with multiple previous surgeries and long courses of antibiotic therapy. In a retrospective series of cases, the surgical approach with higher rates of success consists of a two-stage exchange surgery, but the best antifungal treatment and duration of antifungal treatment are still unclear, and the efficacy of using an antifungal agent-loaded cement spacer is still controversial. Until more evidence is available, focusing on prevention and identifying patients at risk of CPJI seems more than reasonableUniversitat Autònoma de Barcelona 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/255512https://dx.doi.org/urn:doi:10.3390/antibiotics10040458reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2555122026-06-06T12:50:31Z
dc.title.none.fl_str_mv Candida Periprosthetic Joint Infection
Is It Curable?
title Candida Periprosthetic Joint Infection
spellingShingle Candida Periprosthetic Joint Infection
Escolà-Vergé, Laura|||0000-0002-5608-3090
Candida spp
Periprosthetic joint infection
Fungus
Biofilm
Antifungal-loaded cement spacer
Two-stage exchange surgery
title_short Candida Periprosthetic Joint Infection
title_full Candida Periprosthetic Joint Infection
title_fullStr Candida Periprosthetic Joint Infection
title_full_unstemmed Candida Periprosthetic Joint Infection
title_sort Candida Periprosthetic Joint Infection
dc.creator.none.fl_str_mv Escolà-Vergé, Laura|||0000-0002-5608-3090
Rodriguez-Pardo, Dolors|||0000-0001-6781-5405
Corona Pérez-Cardona, Pablo S|||0000-0003-4128-3142
Pigrau, Carlos|||0000-0003-4232-4049
author Escolà-Vergé, Laura|||0000-0002-5608-3090
author_facet Escolà-Vergé, Laura|||0000-0002-5608-3090
Rodriguez-Pardo, Dolors|||0000-0001-6781-5405
Corona Pérez-Cardona, Pablo S|||0000-0003-4128-3142
Pigrau, Carlos|||0000-0003-4232-4049
author_role author
author2 Rodriguez-Pardo, Dolors|||0000-0001-6781-5405
Corona Pérez-Cardona, Pablo S|||0000-0003-4128-3142
Pigrau, Carlos|||0000-0003-4232-4049
author2_role author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Candida spp
Periprosthetic joint infection
Fungus
Biofilm
Antifungal-loaded cement spacer
Two-stage exchange surgery
topic Candida spp
Periprosthetic joint infection
Fungus
Biofilm
Antifungal-loaded cement spacer
Two-stage exchange surgery
description Candida periprosthetic joint infection (CPJI) is a rare and very difficult to treat infection, and high-quality evidence regarding the best management is scarce. Candida spp. adhere to medical devices and grow forming biofilms, which contribute to the persistence and relapse of this infection. Typically, CPJI presents as a chronic infection in a patient with multiple previous surgeries and long courses of antibiotic therapy. In a retrospective series of cases, the surgical approach with higher rates of success consists of a two-stage exchange surgery, but the best antifungal treatment and duration of antifungal treatment are still unclear, and the efficacy of using an antifungal agent-loaded cement spacer is still controversial. Until more evidence is available, focusing on prevention and identifying patients at risk of CPJI seems more than reasonable
publishDate 2021
dc.date.none.fl_str_mv 2
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/255512
https://dx.doi.org/urn:doi:10.3390/antibiotics10040458
url https://ddd.uab.cat/record/255512
https://dx.doi.org/urn:doi:10.3390/antibiotics10040458
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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