Challenges and recommendations for magnetic hyperthermia characterization measurements

[Purpose]: The localized heating of magnetic nanoparticles (MNPs) via the application of time-varying magnetic fields – a process known as magnetic field hyperthermia (MFH) – can greatly enhance existing options for cancer treatment; but for broad clinical uptake its optimization, reproducibility an...

Descripción completa

Detalles Bibliográficos
Autores: Wells, James, Ortega, Daniel, Steinhoff, Uwe, Dutz, Silvio, Garaio, E., Sandre, Olivier, Natividad, Eva, Cruz, Maria Margarida, Brero, Francesca, Southern, Paul, Pankhurst, Quentin A., Spassov, Simo, RADIOMAG consortium
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/265545
Acceso en línea:http://hdl.handle.net/10261/265545
https://doi.org/10.1080/02656736.2021.1892837
Access Level:acceso abierto
id ES_39ef3d09e3cae95982b0b4b59bf387a3
oai_identifier_str oai:digital.csic.es:10261/265545
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Challenges and recommendations for magnetic hyperthermia characterization measurements
title Challenges and recommendations for magnetic hyperthermia characterization measurements
spellingShingle Challenges and recommendations for magnetic hyperthermia characterization measurements
Wells, James
title_short Challenges and recommendations for magnetic hyperthermia characterization measurements
title_full Challenges and recommendations for magnetic hyperthermia characterization measurements
title_fullStr Challenges and recommendations for magnetic hyperthermia characterization measurements
title_full_unstemmed Challenges and recommendations for magnetic hyperthermia characterization measurements
title_sort Challenges and recommendations for magnetic hyperthermia characterization measurements
dc.creator.none.fl_str_mv Wells, James
Ortega, Daniel
Steinhoff, Uwe
Dutz, Silvio
Garaio, E.
Sandre, Olivier
Natividad, Eva
Cruz, Maria Margarida
Brero, Francesca
Southern, Paul
Pankhurst, Quentin A.
Spassov, Simo
RADIOMAG consortium
author Wells, James
author_facet Wells, James
Ortega, Daniel
Steinhoff, Uwe
Dutz, Silvio
Garaio, E.
Sandre, Olivier
Natividad, Eva
Cruz, Maria Margarida
Brero, Francesca
Southern, Paul
Pankhurst, Quentin A.
Spassov, Simo
RADIOMAG consortium
author_role author
author2 Ortega, Daniel
Steinhoff, Uwe
Dutz, Silvio
Garaio, E.
Sandre, Olivier
Natividad, Eva
Cruz, Maria Margarida
Brero, Francesca
Southern, Paul
Pankhurst, Quentin A.
Spassov, Simo
RADIOMAG consortium
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv European Cooperation in Science and Technology
German Research Foundation
Ministerio de Economía y Competitividad (España)
Agencia Estatal de Investigación (España)
Ministerio de Ciencia, Innovación y Universidades (España)
European Commission
Fundação para a Ciência e a Tecnologia (Portugal)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
description [Purpose]: The localized heating of magnetic nanoparticles (MNPs) via the application of time-varying magnetic fields – a process known as magnetic field hyperthermia (MFH) – can greatly enhance existing options for cancer treatment; but for broad clinical uptake its optimization, reproducibility and safety must be comprehensively proven. As part of this effort, the quantification of MNP heating – characterized by the specific loss power (SLP), measured in W/g, or by the intrinsic loss power (ILP), in Hm2/kg – is frequently reported. However, in SLP/ILP measurements to date, the apparatus, the analysis techniques and the field conditions used by different researchers have varied greatly, leading to questions as to the reproducibility of the measurements.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/265545
https://doi.org/10.1080/02656736.2021.1892837
url http://hdl.handle.net/10261/265545
https://doi.org/10.1080/02656736.2021.1892837
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI//RED2018-102626-T
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MAT2017-85617-R
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MAT2017-86826-R
info:eu-repo/grantAgreement/MINECO//SEV-2016-0686
https://doi.org/10.1080/02656736.2021.1892837
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869406202320912385
spelling Challenges and recommendations for magnetic hyperthermia characterization measurementsWells, JamesOrtega, DanielSteinhoff, UweDutz, SilvioGaraio, E.Sandre, OlivierNatividad, EvaCruz, Maria MargaridaBrero, FrancescaSouthern, PaulPankhurst, Quentin A.Spassov, SimoRADIOMAG consortium[Purpose]: The localized heating of magnetic nanoparticles (MNPs) via the application of time-varying magnetic fields – a process known as magnetic field hyperthermia (MFH) – can greatly enhance existing options for cancer treatment; but for broad clinical uptake its optimization, reproducibility and safety must be comprehensively proven. As part of this effort, the quantification of MNP heating – characterized by the specific loss power (SLP), measured in W/g, or by the intrinsic loss power (ILP), in Hm2/kg – is frequently reported. However, in SLP/ILP measurements to date, the apparatus, the analysis techniques and the field conditions used by different researchers have varied greatly, leading to questions as to the reproducibility of the measurements.[Materials and Methods]: An interlaboratory study (across N = 21 European sites) of calorimetry measurements that constitutes a snapshot of the current state-of-the-art within the MFH community has been undertaken. Identical samples of two stable nanoparticle systems were distributed to all participating laboratories. Raw measurement data as well as the results of in-house analysis techniques were collected along with details of the measurement apparatus used. Raw measurement data was further reanalyzed by universal application of the corrected-slope method to examine relative influences of apparatus and results processing.[Results]: The data show that although there is very good intralaboratory repeatability, the overall interlaboratory measurement accuracy is poor, with the consolidated ILP data having standard deviations on the mean of ca. ± 30% to ± 40%. There is a strong systematic component to the uncertainties, and a clear rank correlation between the measuring laboratory and the ILP. Both of these are indications of a current lack of normalization in this field. A number of possible sources of systematic uncertainties are identified, and means determined to alleviate or minimize them. However, no single dominant factor was identified, and significant work remains to ascertain and remove the remaining uncertainty sources.[Conclusion]: We conclude that the study reveals a current lack of harmonization in MFH characterization of MNPs, and highlights the growing need for standardized, quantitative characterization techniques for this emerging medical technology.This article is based upon work supported by the COST action [RADIOMAG TD1402], supported by COST (European Cooperation in Science and Technology). The financial support of the DFG research grants “quantMPI: Establishment of quantitative Magnetic Particle Imaging (MPI) application oriented phantoms for preclinical investigations “(TR 408/9-1) and ‘Matrix in Vision”. [SFB 1340/1 2018, no 372486779, projects A02 and B02] are also gratefully acknowledged. Additional financial support was received from the Spanish Ministry of Economy and Competitiveness through the grants RED2018-102626-T, MAT2017-85617-R, MAT2017-86826-R and the “Severo Ochoa” Program for Centers of Excellence in R&D [SEV-2016-0686]. Additional financial support was received from the Portuguese Foundation for Science and Technology (FCT) under UID/MULTI/04046/2019 (BioISI).Peer reviewedTaylor & FrancisEuropean Cooperation in Science and TechnologyGerman Research FoundationMinisterio de Economía y Competitividad (España)Agencia Estatal de Investigación (España)Ministerio de Ciencia, Innovación y Universidades (España)European CommissionFundação para a Ciência e a Tecnologia (Portugal)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202220222021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/265545https://doi.org/10.1080/02656736.2021.1892837reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI//RED2018-102626-Tinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MAT2017-85617-Rinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MAT2017-86826-Rinfo:eu-repo/grantAgreement/MINECO//SEV-2016-0686https://doi.org/10.1080/02656736.2021.1892837Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2655452026-05-22T06:33:51Z
score 15.812455

Similares en LA Referencia