Challenges and recommendations for magnetic hyperthermia characterization measurements

[Purpose]: The localized heating of magnetic nanoparticles (MNPs) via the application of time-varying magnetic fields – a process known as magnetic field hyperthermia (MFH) – can greatly enhance existing options for cancer treatment; but for broad clinical uptake its optimization, reproducibility an...

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Detalles Bibliográficos
Autores: Wells, James, Ortega, Daniel, Steinhoff, Uwe, Dutz, Silvio, Garaio, E., Sandre, Olivier, Natividad, Eva, Cruz, Maria Margarida, Brero, Francesca, Southern, Paul, Pankhurst, Quentin A., Spassov, Simo, RADIOMAG consortium
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/265545
Acceso en línea:http://hdl.handle.net/10261/265545
https://doi.org/10.1080/02656736.2021.1892837
Access Level:acceso abierto
Descripción
Sumario:[Purpose]: The localized heating of magnetic nanoparticles (MNPs) via the application of time-varying magnetic fields – a process known as magnetic field hyperthermia (MFH) – can greatly enhance existing options for cancer treatment; but for broad clinical uptake its optimization, reproducibility and safety must be comprehensively proven. As part of this effort, the quantification of MNP heating – characterized by the specific loss power (SLP), measured in W/g, or by the intrinsic loss power (ILP), in Hm2/kg – is frequently reported. However, in SLP/ILP measurements to date, the apparatus, the analysis techniques and the field conditions used by different researchers have varied greatly, leading to questions as to the reproducibility of the measurements.