Epidemiology of sepsis in Catalonia: analysis of incidence and outcomes in a European setting

Background: Up-to-date identification of local trends in sepsis incidence and outcomes is of considerable public health importance. The aim of our study was to estimate annual incidence rates and in-hospital mortality trends for hospitalized patients with sepsis in a European setting, while avoiding...

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Authors: Yébenes, JC, Ruiz-Rodriguez, JC, Ferrer, R, Clèries, M, Bosch, A, Lorencio, C, Rodriguez, A, Nuvials, X, Martin-Loeches, I, Artigas, A
Format: article
Status:Published version
Publication Date:2017
Country:España
Institution:Institut d'Investigació i Innovació Parc Taulí (I3PT)
Repository:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
OAI Identifier:oai:i3pt.fundanetsuite.com:p4608
Online Access:https://i3pt.portalinvestigacion.com/publicaciones/4608
Access Level:Open access
Keyword:Sepsis
Septic shock
Mortality
Epidemiology
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spelling Epidemiology of sepsis in Catalonia: analysis of incidence and outcomes in a European settingYébenes, JCRuiz-Rodriguez, JCFerrer, RClèries, MBosch, ALorencio, CRodriguez, ANuvials, XMartin-Loeches, IArtigas, ASepsisSeptic shockMortalityEpidemiologyBackground: Up-to-date identification of local trends in sepsis incidence and outcomes is of considerable public health importance. The aim of our study was to estimate annual incidence rates and in-hospital mortality trends for hospitalized patients with sepsis in a European setting, while avoiding selection bias in relation to different complexity hospitals. Methods: A large retrospective analysis of a 5-year period (2008-2012) was conducted of hospital discharge records obtained from the Catalan Health System (CatSalut) Minimum Basic Data Set for Acute-Care Hospitals (a mandatory population-based register of admissions to all public and private acute-care hospitals in Catalonia). Patients hospitalized with sepsis were detected on the basis of ICD-9-CM codes used to identify acute organ dysfunction and infectious processes. Results: Of 4,761,726 discharges from all acute-care hospitals in Catalonia, 82,300 cases (1.72%) had sepsis diagnoses. Annual incidence was 212.7 per 100,000 inhabitants/year, rising from 167.2 in 2008 to 261.8 in 2012. Length of hospital stay fell from 18.4 to 15.3 days (p < .00001), representing a relative reduction of 17%. Hospital mortality fell from 23.7 to 19.7% (p < .0001), representing a relative reduction of 16.9%. These differences were confirmed in the multi-variate analysis (adjusted for age group, sex, comorbidities, ICU admission, emergency admission, organ dysfunction, number of organ failures, sepsis source and bacteraemia). Conclusions: Sepsis incidence has risen in recent years, whereas mortality has fallen. Our findings confirm reports for other parts of the world, in the context of scarce administrative data on sepsis in Europe.ELSEVIER2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://i3pt.portalinvestigacion.com/publicaciones/4608Annals of Intensive CareISSN: 21105820reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulíinstname:Institut d'Investigació i Innovació Parc Taulí (I3PT)Inglésinfo:eu-repo/semantics/openAccessoai:i3pt.fundanetsuite.com:p46082026-06-21T15:30:37Z
dc.title.none.fl_str_mv Epidemiology of sepsis in Catalonia: analysis of incidence and outcomes in a European setting
title Epidemiology of sepsis in Catalonia: analysis of incidence and outcomes in a European setting
spellingShingle Epidemiology of sepsis in Catalonia: analysis of incidence and outcomes in a European setting
Yébenes, JC
Sepsis
Septic shock
Mortality
Epidemiology
title_short Epidemiology of sepsis in Catalonia: analysis of incidence and outcomes in a European setting
title_full Epidemiology of sepsis in Catalonia: analysis of incidence and outcomes in a European setting
title_fullStr Epidemiology of sepsis in Catalonia: analysis of incidence and outcomes in a European setting
title_full_unstemmed Epidemiology of sepsis in Catalonia: analysis of incidence and outcomes in a European setting
title_sort Epidemiology of sepsis in Catalonia: analysis of incidence and outcomes in a European setting
dc.creator.none.fl_str_mv Yébenes, JC
Ruiz-Rodriguez, JC
Ferrer, R
Clèries, M
Bosch, A
Lorencio, C
Rodriguez, A
Nuvials, X
Martin-Loeches, I
Artigas, A
author Yébenes, JC
author_facet Yébenes, JC
Ruiz-Rodriguez, JC
Ferrer, R
Clèries, M
Bosch, A
Lorencio, C
Rodriguez, A
Nuvials, X
Martin-Loeches, I
Artigas, A
author_role author
author2 Ruiz-Rodriguez, JC
Ferrer, R
Clèries, M
Bosch, A
Lorencio, C
Rodriguez, A
Nuvials, X
Martin-Loeches, I
Artigas, A
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Sepsis
Septic shock
Mortality
Epidemiology
topic Sepsis
Septic shock
Mortality
Epidemiology
description Background: Up-to-date identification of local trends in sepsis incidence and outcomes is of considerable public health importance. The aim of our study was to estimate annual incidence rates and in-hospital mortality trends for hospitalized patients with sepsis in a European setting, while avoiding selection bias in relation to different complexity hospitals. Methods: A large retrospective analysis of a 5-year period (2008-2012) was conducted of hospital discharge records obtained from the Catalan Health System (CatSalut) Minimum Basic Data Set for Acute-Care Hospitals (a mandatory population-based register of admissions to all public and private acute-care hospitals in Catalonia). Patients hospitalized with sepsis were detected on the basis of ICD-9-CM codes used to identify acute organ dysfunction and infectious processes. Results: Of 4,761,726 discharges from all acute-care hospitals in Catalonia, 82,300 cases (1.72%) had sepsis diagnoses. Annual incidence was 212.7 per 100,000 inhabitants/year, rising from 167.2 in 2008 to 261.8 in 2012. Length of hospital stay fell from 18.4 to 15.3 days (p < .00001), representing a relative reduction of 17%. Hospital mortality fell from 23.7 to 19.7% (p < .0001), representing a relative reduction of 16.9%. These differences were confirmed in the multi-variate analysis (adjusted for age group, sex, comorbidities, ICU admission, emergency admission, organ dysfunction, number of organ failures, sepsis source and bacteraemia). Conclusions: Sepsis incidence has risen in recent years, whereas mortality has fallen. Our findings confirm reports for other parts of the world, in the context of scarce administrative data on sepsis in Europe.
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://i3pt.portalinvestigacion.com/publicaciones/4608
url https://i3pt.portalinvestigacion.com/publicaciones/4608
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ELSEVIER
publisher.none.fl_str_mv ELSEVIER
dc.source.none.fl_str_mv Annals of Intensive Care
ISSN: 21105820
reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
instname:Institut d'Investigació i Innovació Parc Taulí (I3PT)
instname_str Institut d'Investigació i Innovació Parc Taulí (I3PT)
reponame_str r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
collection r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
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