Fucose dependent rotavirus and norovirus require fucosidase activity for optimal replication

Rotavirus (RV) and norovirus (NoV) are enteric viruses responsible for acute gastroenteritis that require fucosylated histo-blood group antigens for infection in humans. How the interaction of these viruses with fucosylated glycans modulates infection is not well understood. Treatment of target cell...

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Detalhes bibliográficos
Autores: Peña-Gil, Nazaret, Santos Ferreira, Nanci, Llanos Villatoro, Sonia, Melero, Ana, Cárcamo Calvo, Roberto, López Navarro, Sergi, Santiso Bellón, Cristina, Buesa, Javier, Monedero, Vicente, Yebra, María Jesús, Rocha Pereira, Joana, Gozalbo-Rovira, Roberto, Rodríguez-Díaz, Jesús
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/422879
Acesso em linha:http://hdl.handle.net/10261/422879
Access Level:acceso abierto
Palavra-chave:Fucose
fucosidase
Viruses
Viral replication
viruses
viral replication
fucose
Descrição
Resumo:Rotavirus (RV) and norovirus (NoV) are enteric viruses responsible for acute gastroenteritis that require fucosylated histo-blood group antigens for infection in humans. How the interaction of these viruses with fucosylated glycans modulates infection is not well understood. Treatment of target cells with a bacterial α1,2 fucosidase enzyme reduced RV and NoV infection in vitro, but increased replication in vivo. Conversely, the fucosidase inhibitor 1-deoxyfuconojirimycin impaired viral replication in both models, highlighting the role of fucosidase activity in fucose-dependent enteric virus infection. This underscores the complexity of fucose interactions for these viruses and implicates fucosidase activity as a potential antiviral target for RV and NoV.

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