Fucose dependent rotavirus and norovirus require fucosidase activity for optimal replication

Rotavirus (RV) and norovirus (NoV) are enteric viruses responsible for acute gastroenteritis that require fucosylated histo-blood group antigens for infection in humans. How the interaction of these viruses with fucosylated glycans modulates infection is not well understood. Treatment of target cell...

Descripción completa

Detalles Bibliográficos
Autores: Peña-Gil, Nazaret, Santos Ferreira, Nanci, Llanos Villatoro, Sonia, Melero, Ana, Cárcamo Calvo, Roberto, López Navarro, Sergi, Santiso Bellón, Cristina, Buesa, Javier, Monedero, Vicente, Yebra, María Jesús, Rocha Pereira, Joana, Gozalbo-Rovira, Roberto, Rodríguez-Díaz, Jesús
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/422879
Acceso en línea:http://hdl.handle.net/10261/422879
Access Level:acceso abierto
Palabra clave:Fucose
fucosidase
Viruses
Viral replication
viruses
viral replication
fucose
Descripción
Sumario:Rotavirus (RV) and norovirus (NoV) are enteric viruses responsible for acute gastroenteritis that require fucosylated histo-blood group antigens for infection in humans. How the interaction of these viruses with fucosylated glycans modulates infection is not well understood. Treatment of target cells with a bacterial α1,2 fucosidase enzyme reduced RV and NoV infection in vitro, but increased replication in vivo. Conversely, the fucosidase inhibitor 1-deoxyfuconojirimycin impaired viral replication in both models, highlighting the role of fucosidase activity in fucose-dependent enteric virus infection. This underscores the complexity of fucose interactions for these viruses and implicates fucosidase activity as a potential antiviral target for RV and NoV.

Similares en LA Referencia