Long-term efficacy of autologous bone marrow mesenchymal stromal cells for treatment of knee osteoarthritis
Knee osteoarthritis is the most prevalent joint disease and a frequent cause of pain, functional loss and disability. Conventional treatments have demonstrated only modest clinical benefits whereas cell-based therapies have shown encouraging results, but important details, such as dose needed, long-...
| Autores: | , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/116024 |
| Acceso en línea: | https://hdl.handle.net/10171/116024 |
| Access Level: | acceso abierto |
| Palabra clave: | Intraarticular injection Mesenchymal stem cells Osteoarthritis Regenerative medicine Stem cell therapy |
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Long-term efficacy of autologous bone marrow mesenchymal stromal cells for treatment of knee osteoarthritisLamo-de-Espinosa-Vázquez-de-Sola, J.M. (José María)|||/items/75feb837-6d53-41fe-808d-4b70661db44eProsper-Cardoso, F. (Felipe)|||/items/3d1b0b82-06c3-4e63-8280-e903dc4dc0c1Blanco‐Libreros, J.F. (Juan F.)|||/items/e0f931b1-805f-46ba-8190-9ec1f0657344Sanchez-Guijo, F.M. (Fermín M.)|||/items/b31fe6cf-bc6a-42fb-8a92-116c4f62dd49Alberca, M. (Mercedes)|||/items/4f3494b9-bdc5-459c-a852-390b600f4e14García-Díaz, V. (Verónica)|||/items/9be6712d-2429-4af3-8d46-5f2cec6754e6González‑Vallinas, M. (Margarita)|||/items/af3d91b5-081d-40f1-b4d4-f1cf5f1ca306García-Sancho, J. (Javier)|||/items/7cc25a28-bc44-4622-8011-76df4682eadaIntraarticular injectionMesenchymal stem cellsOsteoarthritisRegenerative medicineStem cell therapyKnee osteoarthritis is the most prevalent joint disease and a frequent cause of pain, functional loss and disability. Conventional treatments have demonstrated only modest clinical benefits whereas cell-based therapies have shown encouraging results, but important details, such as dose needed, long-term evolution or number of applications required are scarcely known. Here we have reanalyzed results from two recent pilot trials with autologous bone marrow-derived mesenchymal stromal cells using the Huskisson plot to enhance quantification of efficacy and comparability. We find that cell doses of 10, 40 and 100 million autologous cells per knee provided quite similar healing results and that much of the effect attained 1 year after cell application remained after 2 and 4 years. These results are encouraging because they indicate that, apart from safety and simplicity: (i) the beneficial effect is both significant and sizeable, (ii) it can be achieved with a single injection of cells, and (iii) the effect is perdurable for years.Trial registration: EudraCT 2009-017405-11; NCT02123368. Registered 25 April 2014-Prospectively registered, https://clinicaltrials.gov/ct2/show/NCT02123368?term=02123368&draw=2&rank=1.Springer NatureDadun. Depósito Académico Digital Universidad de Navarra20212021-01-0120212021-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/116024reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/1160242026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
Long-term efficacy of autologous bone marrow mesenchymal stromal cells for treatment of knee osteoarthritis |
| title |
Long-term efficacy of autologous bone marrow mesenchymal stromal cells for treatment of knee osteoarthritis |
| spellingShingle |
Long-term efficacy of autologous bone marrow mesenchymal stromal cells for treatment of knee osteoarthritis Lamo-de-Espinosa-Vázquez-de-Sola, J.M. (José María)|||/items/75feb837-6d53-41fe-808d-4b70661db44e Intraarticular injection Mesenchymal stem cells Osteoarthritis Regenerative medicine Stem cell therapy |
| title_short |
Long-term efficacy of autologous bone marrow mesenchymal stromal cells for treatment of knee osteoarthritis |
| title_full |
Long-term efficacy of autologous bone marrow mesenchymal stromal cells for treatment of knee osteoarthritis |
| title_fullStr |
Long-term efficacy of autologous bone marrow mesenchymal stromal cells for treatment of knee osteoarthritis |
| title_full_unstemmed |
Long-term efficacy of autologous bone marrow mesenchymal stromal cells for treatment of knee osteoarthritis |
| title_sort |
Long-term efficacy of autologous bone marrow mesenchymal stromal cells for treatment of knee osteoarthritis |
| dc.creator.none.fl_str_mv |
Lamo-de-Espinosa-Vázquez-de-Sola, J.M. (José María)|||/items/75feb837-6d53-41fe-808d-4b70661db44e Prosper-Cardoso, F. (Felipe)|||/items/3d1b0b82-06c3-4e63-8280-e903dc4dc0c1 Blanco‐Libreros, J.F. (Juan F.)|||/items/e0f931b1-805f-46ba-8190-9ec1f0657344 Sanchez-Guijo, F.M. (Fermín M.)|||/items/b31fe6cf-bc6a-42fb-8a92-116c4f62dd49 Alberca, M. (Mercedes)|||/items/4f3494b9-bdc5-459c-a852-390b600f4e14 García-Díaz, V. (Verónica)|||/items/9be6712d-2429-4af3-8d46-5f2cec6754e6 González‑Vallinas, M. (Margarita)|||/items/af3d91b5-081d-40f1-b4d4-f1cf5f1ca306 García-Sancho, J. (Javier)|||/items/7cc25a28-bc44-4622-8011-76df4682eada |
| author |
Lamo-de-Espinosa-Vázquez-de-Sola, J.M. (José María)|||/items/75feb837-6d53-41fe-808d-4b70661db44e |
| author_facet |
Lamo-de-Espinosa-Vázquez-de-Sola, J.M. (José María)|||/items/75feb837-6d53-41fe-808d-4b70661db44e Prosper-Cardoso, F. (Felipe)|||/items/3d1b0b82-06c3-4e63-8280-e903dc4dc0c1 Blanco‐Libreros, J.F. (Juan F.)|||/items/e0f931b1-805f-46ba-8190-9ec1f0657344 Sanchez-Guijo, F.M. (Fermín M.)|||/items/b31fe6cf-bc6a-42fb-8a92-116c4f62dd49 Alberca, M. (Mercedes)|||/items/4f3494b9-bdc5-459c-a852-390b600f4e14 García-Díaz, V. (Verónica)|||/items/9be6712d-2429-4af3-8d46-5f2cec6754e6 González‑Vallinas, M. (Margarita)|||/items/af3d91b5-081d-40f1-b4d4-f1cf5f1ca306 García-Sancho, J. (Javier)|||/items/7cc25a28-bc44-4622-8011-76df4682eada |
| author_role |
author |
| author2 |
Prosper-Cardoso, F. (Felipe)|||/items/3d1b0b82-06c3-4e63-8280-e903dc4dc0c1 Blanco‐Libreros, J.F. (Juan F.)|||/items/e0f931b1-805f-46ba-8190-9ec1f0657344 Sanchez-Guijo, F.M. (Fermín M.)|||/items/b31fe6cf-bc6a-42fb-8a92-116c4f62dd49 Alberca, M. (Mercedes)|||/items/4f3494b9-bdc5-459c-a852-390b600f4e14 García-Díaz, V. (Verónica)|||/items/9be6712d-2429-4af3-8d46-5f2cec6754e6 González‑Vallinas, M. (Margarita)|||/items/af3d91b5-081d-40f1-b4d4-f1cf5f1ca306 García-Sancho, J. (Javier)|||/items/7cc25a28-bc44-4622-8011-76df4682eada |
| author2_role |
author author author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
Intraarticular injection Mesenchymal stem cells Osteoarthritis Regenerative medicine Stem cell therapy |
| topic |
Intraarticular injection Mesenchymal stem cells Osteoarthritis Regenerative medicine Stem cell therapy |
| description |
Knee osteoarthritis is the most prevalent joint disease and a frequent cause of pain, functional loss and disability. Conventional treatments have demonstrated only modest clinical benefits whereas cell-based therapies have shown encouraging results, but important details, such as dose needed, long-term evolution or number of applications required are scarcely known. Here we have reanalyzed results from two recent pilot trials with autologous bone marrow-derived mesenchymal stromal cells using the Huskisson plot to enhance quantification of efficacy and comparability. We find that cell doses of 10, 40 and 100 million autologous cells per knee provided quite similar healing results and that much of the effect attained 1 year after cell application remained after 2 and 4 years. These results are encouraging because they indicate that, apart from safety and simplicity: (i) the beneficial effect is both significant and sizeable, (ii) it can be achieved with a single injection of cells, and (iii) the effect is perdurable for years.Trial registration: EudraCT 2009-017405-11; NCT02123368. Registered 25 April 2014-Prospectively registered, https://clinicaltrials.gov/ct2/show/NCT02123368?term=02123368&draw=2&rank=1. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2021-01-01 2021 2021-01-01 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/116024 |
| url |
https://hdl.handle.net/10171/116024 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Springer Nature |
| publisher.none.fl_str_mv |
Springer Nature |
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reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
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Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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1869406005876490240 |
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15,811543 |