3D self-assembly of cyclic peptides into multilayered nanosheets

The hierarchical self-assembly of three-dimensional (3D) supramolecular materials presents a significant challenge in molecular design. This process requires monomers with specific packing geometries and orthogonal contacts to enable multidimensional elongation. Here, we describe a new cyclic peptid...

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Detalles Bibliográficos
Autores: Díaz Arias, Sandra Natalia, Sánchez Fernández, Adrián, Granja Guillán, Juan Ramón, Insua López, Ignacio, Montenegro García, Javier
Tipo de recurso: artículo
Fecha de publicación:2026
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:dnet:minerva_____::8f32bc73ab7e47685535ec018c4b7174
Acceso en línea:https://hdl.handle.net/10347/46806
Access Level:acceso abierto
Palabra clave:3303 ingeniería y tecnología químicas
Descripción
Sumario:The hierarchical self-assembly of three-dimensional (3D) supramolecular materials presents a significant challenge in molecular design. This process requires monomers with specific packing geometries and orthogonal contacts to enable multidimensional elongation. Here, we describe a new cyclic peptide design that allows hierarchical self-assembly in all three spatial dimensions to produce nanosheets composed of ordered nanotube layers. The uniformity of the nanosheet aspect ratio and thickness is consistent with the high packing order of the monomers observed in this 3D assembly.