Bioactive properties of blueberry extracts obtained by different drying techniques against Helicobacter pylori

Helicobacter pylori (H. pylori) is widely recognised as one of the most prevalent human pathogens, which infects more than 50% of the population worldwide. Chronic inflammation of the gastric mucosa is one of the main consequences of this infection and is related to the risk of developing gastric ca...

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Autores: Silván, José Manuel, Michalska-Ciechanowska, Anna, Villalva, Marisol, Brzezowska, Jessica, Díaz, Soledad, Martínez-Rodríguez, Adolfo J.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/285066
Acceso en línea:http://hdl.handle.net/10261/285066
Access Level:acceso abierto
Palabra clave:Helicobacter
Anti-inflammatory activity
Blueberry extracts
Antibacterial activity
Drying methods
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spelling Bioactive properties of blueberry extracts obtained by different drying techniques against Helicobacter pyloriSilván, José ManuelMichalska-Ciechanowska, AnnaVillalva, MarisolBrzezowska, JessicaDíaz, SoledadMartínez-Rodríguez, Adolfo J.HelicobacterAnti-inflammatory activityBlueberry extractsAntibacterial activityDrying methodsHelicobacter pylori (H. pylori) is widely recognised as one of the most prevalent human pathogens, which infects more than 50% of the population worldwide. Chronic inflammation of the gastric mucosa is one of the main consequences of this infection and is related to the risk of developing gastric cancer. Currently, due to the high association between H. pylori infection and the progression of gastric cancer, most therapeutic treatments aim to eradicate the bacteria using different antibiotics in combination with a proton pump inhibitor in triple or quadruple therapy. However, resistant strains have increased significantly, requiring new therapeutic tools. Blueberries are rich in different bioactive compounds with antibacterial and anti-inflammatory properties that could contribute to reducing the problems associated with H. pylori infection. The aim of this research was to analyse the antibacterial and anti-inflammatory properties of different blueberry extracts (from Bluejay, Berkley, and Bluecrop varieties) obtained by different drying methods (freeze-drying (FD), vacuum drying at 50 °C, 70 °C and 90 °C (VD), and spray drying (SD)) against H. pylori infection. The results showed that all blueberry extracts exhibited antibacterial effects against H. pylori, with some of these extracts being bactericidal, while the rest reduced bacterial growth by more than 5 log CFU/mL. The Bluecrop extracts were the most active because all the extracts obtained by the different drying methods were bactericidal. The extracts obtained by vacuum drying (VD) at 50ºC were the most effective since the extracts of the three varieties were bactericidal. Regarding anti-inflammatory activity, all blueberry extracts reduced IL-8 secretion in the H. pylori-infected gastric cells. The Bluecrop extracts obtained by VD at 70 °C and 90 °C reduced IL-8 production by 30% and 32%, respectively. These results suggest that the blueberry extracts used in the present work and obtained by different drying methods could constitute a useful alternative for controlling H. pylori growth and in the modulation of the gastric inflammatory process induced in H. pylori infection.This research was funded by MINECO (Spain), Project HELIFOOD (AGL2017-89566-R).Peer reviewedMultidisciplinary Digital Publishing InstituteMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)Ministerio de Economía y Competitividad (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202220222022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/285066reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2017-89566-RThe underlying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.3390/Foods2022-13013https://doi.org/10.3390/Foods2022-13013Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2850662026-05-22T06:33:51Z
dc.title.none.fl_str_mv Bioactive properties of blueberry extracts obtained by different drying techniques against Helicobacter pylori
title Bioactive properties of blueberry extracts obtained by different drying techniques against Helicobacter pylori
spellingShingle Bioactive properties of blueberry extracts obtained by different drying techniques against Helicobacter pylori
Silván, José Manuel
Helicobacter
Anti-inflammatory activity
Blueberry extracts
Antibacterial activity
Drying methods
title_short Bioactive properties of blueberry extracts obtained by different drying techniques against Helicobacter pylori
title_full Bioactive properties of blueberry extracts obtained by different drying techniques against Helicobacter pylori
title_fullStr Bioactive properties of blueberry extracts obtained by different drying techniques against Helicobacter pylori
title_full_unstemmed Bioactive properties of blueberry extracts obtained by different drying techniques against Helicobacter pylori
title_sort Bioactive properties of blueberry extracts obtained by different drying techniques against Helicobacter pylori
dc.creator.none.fl_str_mv Silván, José Manuel
Michalska-Ciechanowska, Anna
Villalva, Marisol
Brzezowska, Jessica
Díaz, Soledad
Martínez-Rodríguez, Adolfo J.
author Silván, José Manuel
author_facet Silván, José Manuel
Michalska-Ciechanowska, Anna
Villalva, Marisol
Brzezowska, Jessica
Díaz, Soledad
Martínez-Rodríguez, Adolfo J.
author_role author
author2 Michalska-Ciechanowska, Anna
Villalva, Marisol
Brzezowska, Jessica
Díaz, Soledad
Martínez-Rodríguez, Adolfo J.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
Ministerio de Economía y Competitividad (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Helicobacter
Anti-inflammatory activity
Blueberry extracts
Antibacterial activity
Drying methods
topic Helicobacter
Anti-inflammatory activity
Blueberry extracts
Antibacterial activity
Drying methods
description Helicobacter pylori (H. pylori) is widely recognised as one of the most prevalent human pathogens, which infects more than 50% of the population worldwide. Chronic inflammation of the gastric mucosa is one of the main consequences of this infection and is related to the risk of developing gastric cancer. Currently, due to the high association between H. pylori infection and the progression of gastric cancer, most therapeutic treatments aim to eradicate the bacteria using different antibiotics in combination with a proton pump inhibitor in triple or quadruple therapy. However, resistant strains have increased significantly, requiring new therapeutic tools. Blueberries are rich in different bioactive compounds with antibacterial and anti-inflammatory properties that could contribute to reducing the problems associated with H. pylori infection. The aim of this research was to analyse the antibacterial and anti-inflammatory properties of different blueberry extracts (from Bluejay, Berkley, and Bluecrop varieties) obtained by different drying methods (freeze-drying (FD), vacuum drying at 50 °C, 70 °C and 90 °C (VD), and spray drying (SD)) against H. pylori infection. The results showed that all blueberry extracts exhibited antibacterial effects against H. pylori, with some of these extracts being bactericidal, while the rest reduced bacterial growth by more than 5 log CFU/mL. The Bluecrop extracts were the most active because all the extracts obtained by the different drying methods were bactericidal. The extracts obtained by vacuum drying (VD) at 50ºC were the most effective since the extracts of the three varieties were bactericidal. Regarding anti-inflammatory activity, all blueberry extracts reduced IL-8 secretion in the H. pylori-infected gastric cells. The Bluecrop extracts obtained by VD at 70 °C and 90 °C reduced IL-8 production by 30% and 32%, respectively. These results suggest that the blueberry extracts used in the present work and obtained by different drying methods could constitute a useful alternative for controlling H. pylori growth and in the modulation of the gastric inflammatory process induced in H. pylori infection.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/285066
url http://hdl.handle.net/10261/285066
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2017-89566-R
The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.3390/Foods2022-13013
https://doi.org/10.3390/Foods2022-13013
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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