90 years of progesterone: molecular mechanisms of progesterone receptor action on the breast cancer genome

First, the authors thank all the members of the Chromatin and Gene Expression Group, who had performed most of the experiments commented in this review and have made suggestions for the text. The authors also thank their collaborators, most of them cited as authors of the referenced papers. The auth...

Descripción completa

Detalles Bibliográficos
Autores: Beato, Miguel, Wright, Roni, Le Dily, François
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:20.500.12328/3008
Acceso en línea:http://hdl.handle.net/20.500.12328/3008
https://dx.doi.org/10.1530/JME-19-0266
Access Level:acceso abierto
Palabra clave:Hormones esteroides
Mecanismes moleculars
Receptor de progesterona
Càncer de mama
Genoma
Hormonas esteroides
Mecanismos moleculares
Cáncer de mama
Steroid hormones
Molecular mechanisms
Progesterone receptor
Breast cancer
Genome
61
616
id ES_36198fa5d4ac047cd41cecbdb228dbe2
oai_identifier_str oai:recercat.cat:20.500.12328/3008
network_acronym_str ES
network_name_str España
repository_id_str
spelling 90 years of progesterone: molecular mechanisms of progesterone receptor action on the breast cancer genomeBeato, MiguelWright, RoniLe Dily, FrançoisHormones esteroidesMecanismes molecularsReceptor de progesteronaCàncer de mamaGenomaHormonas esteroidesMecanismos molecularesReceptor de progesteronaCáncer de mamaGenomaSteroid hormonesMolecular mechanismsProgesterone receptorBreast cancerGenome61616First, the authors thank all the members of the Chromatin and Gene Expression Group, who had performed most of the experiments commented in this review and have made suggestions for the text. The authors also thank their collaborators, most of them cited as authors of the referenced papers. The authors thank the CRG for the continuous support of the group and for the availability of essential core facilities. The experimental work mentioned was supported by the core funding of the CRG, the European Research Council (Project ‘4D Genome’ 609989), the Ministerio de Economía y Competitividad (Project G62426937) and the Generalitat de Catalunya (Project AGAUR SGR 575). We acknowledge support of the Spanish Ministry of Economy, Industry and Competitiveness (MEIC) to the EMBL partnership, the Centro de Excelencia Severo Ochoa as well as CERCA Programme / Generalitat de Catalunya.Gene regulation by steroid hormones has been at the forefront in elucidating the intricacies of transcriptional regulation in eukaryotes ever since the discovery by Karlson and Clever that the insect steroid hormone ecdysone induces chromatin puffs in giant chromosomes. After the successful cloning of the hormone receptors toward the end of the past century, detailed mechanistic insight emerged in some model systems, in particular the MMTV provirus. With the arrival of next generation DNA sequencing and the omics techniques, we have gained even further insight into the global cellular response to steroid hormones that in the past decades also extended to the function of the 3D genome topology. More recently, advances in high resolution microcopy, single cell genomics and the new vision of liquid-liquid phase transitions in the context of nuclear space bring us closer than ever to unravelling the logic of gene regulation and its complex integration of global cellular signaling networks. Using the function of progesterone and its cellular receptor in breast cancer cells, we will briefly summarize the history and describe the present extent of our knowledge on how regulatory proteins deal with the chromatin structure to gain access to DNA sequences and interpret the genomic instructions that enable cells to respond selectively to external signals by reshaping their gene regulatory networks.info:eu-repo/semantics/publishedVersionBioscientifica Ltd.2020info:eu-repo/semantics/article15http://hdl.handle.net/20.500.12328/3008https://dx.doi.org/10.1530/JME-19-0266reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésJournal of Molecular Endocrinology65;1© 2020 The authors. Published by Bioscientifica Ltd. Printed in Great Britain. This work is licensed under a Creative Commons Attribution 4.0 International License.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:20.500.12328/30082026-05-29T05:05:01Z
dc.title.none.fl_str_mv 90 years of progesterone: molecular mechanisms of progesterone receptor action on the breast cancer genome
title 90 years of progesterone: molecular mechanisms of progesterone receptor action on the breast cancer genome
spellingShingle 90 years of progesterone: molecular mechanisms of progesterone receptor action on the breast cancer genome
Beato, Miguel
Hormones esteroides
Mecanismes moleculars
Receptor de progesterona
Càncer de mama
Genoma
Hormonas esteroides
Mecanismos moleculares
Receptor de progesterona
Cáncer de mama
Genoma
Steroid hormones
Molecular mechanisms
Progesterone receptor
Breast cancer
Genome
61
616
title_short 90 years of progesterone: molecular mechanisms of progesterone receptor action on the breast cancer genome
title_full 90 years of progesterone: molecular mechanisms of progesterone receptor action on the breast cancer genome
title_fullStr 90 years of progesterone: molecular mechanisms of progesterone receptor action on the breast cancer genome
title_full_unstemmed 90 years of progesterone: molecular mechanisms of progesterone receptor action on the breast cancer genome
title_sort 90 years of progesterone: molecular mechanisms of progesterone receptor action on the breast cancer genome
dc.creator.none.fl_str_mv Beato, Miguel
Wright, Roni
Le Dily, François
author Beato, Miguel
author_facet Beato, Miguel
Wright, Roni
Le Dily, François
author_role author
author2 Wright, Roni
Le Dily, François
author2_role author
author
dc.subject.none.fl_str_mv Hormones esteroides
Mecanismes moleculars
Receptor de progesterona
Càncer de mama
Genoma
Hormonas esteroides
Mecanismos moleculares
Receptor de progesterona
Cáncer de mama
Genoma
Steroid hormones
Molecular mechanisms
Progesterone receptor
Breast cancer
Genome
61
616
topic Hormones esteroides
Mecanismes moleculars
Receptor de progesterona
Càncer de mama
Genoma
Hormonas esteroides
Mecanismos moleculares
Receptor de progesterona
Cáncer de mama
Genoma
Steroid hormones
Molecular mechanisms
Progesterone receptor
Breast cancer
Genome
61
616
description First, the authors thank all the members of the Chromatin and Gene Expression Group, who had performed most of the experiments commented in this review and have made suggestions for the text. The authors also thank their collaborators, most of them cited as authors of the referenced papers. The authors thank the CRG for the continuous support of the group and for the availability of essential core facilities. The experimental work mentioned was supported by the core funding of the CRG, the European Research Council (Project ‘4D Genome’ 609989), the Ministerio de Economía y Competitividad (Project G62426937) and the Generalitat de Catalunya (Project AGAUR SGR 575). We acknowledge support of the Spanish Ministry of Economy, Industry and Competitiveness (MEIC) to the EMBL partnership, the Centro de Excelencia Severo Ochoa as well as CERCA Programme / Generalitat de Catalunya.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12328/3008
https://dx.doi.org/10.1530/JME-19-0266
url http://hdl.handle.net/20.500.12328/3008
https://dx.doi.org/10.1530/JME-19-0266
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Journal of Molecular Endocrinology
65;1
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 15
dc.publisher.none.fl_str_mv Bioscientifica Ltd.
publisher.none.fl_str_mv Bioscientifica Ltd.
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869405936560373760
score 15,811543

Similares en LA Referencia