A Shortcut from Metabolic-Associated Fatty Liver Disease (MAFLD) to Hepatocellular Carcinoma (HCC): c-MYC a Promising Target for Preventative Strategies and Individualized Therapy

Metabolic-associated fatty liver disease (MAFLD) has risen as one of the leading etiologies for hepatocellular carcinoma (HCC). Oncogenes have been suggested to be responsible for the high risk of MAFLD-related HCC. We analyzed the impact of the proto-oncogene c-MYC in the development of human and m...

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Autores: Guo, Feifei, Estévez-Vázquez, Olga, Benedé-Ubieto, Raquel, Maya-Miles, Douglas, Zheng, Kang, Gallego-Durán, Rocío, Rojas, Ángela, Ampuero, Javier, Romero-Gómez, Manuel, Philip, Kaye, Egbuniwe, Isioma U., Chen, Chaobo, Simon, Jorge, Delgado, Teresa C., Martínez-Chantar, María Luz, Sun, Jie, Reissing, Johanna, Bruns, Tony, Lamas-Paz, Arantza, Gómez del Moral, Manuel, Woitok, Marius Maximilian, Vaquero, Javier, Regueiro, José R., Liedtke, Christian, Trautwein, Christian, Bañares, Rafael, Cubero, Javier, Nevzorova, Yulia A.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/296122
Acceso en línea:http://hdl.handle.net/10261/296122
https://api.elsevier.com/content/abstract/scopus_id/85122071976
Access Level:acceso abierto
Palabra clave:Tumorigenesis
C-myc
Metabolic-associated fatty liver disease
Metformin
Oncogene
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dc.title.none.fl_str_mv A Shortcut from Metabolic-Associated Fatty Liver Disease (MAFLD) to Hepatocellular Carcinoma (HCC): c-MYC a Promising Target for Preventative Strategies and Individualized Therapy
title A Shortcut from Metabolic-Associated Fatty Liver Disease (MAFLD) to Hepatocellular Carcinoma (HCC): c-MYC a Promising Target for Preventative Strategies and Individualized Therapy
spellingShingle A Shortcut from Metabolic-Associated Fatty Liver Disease (MAFLD) to Hepatocellular Carcinoma (HCC): c-MYC a Promising Target for Preventative Strategies and Individualized Therapy
Guo, Feifei
Tumorigenesis
C-myc
Metabolic-associated fatty liver disease
Metformin
Oncogene
title_short A Shortcut from Metabolic-Associated Fatty Liver Disease (MAFLD) to Hepatocellular Carcinoma (HCC): c-MYC a Promising Target for Preventative Strategies and Individualized Therapy
title_full A Shortcut from Metabolic-Associated Fatty Liver Disease (MAFLD) to Hepatocellular Carcinoma (HCC): c-MYC a Promising Target for Preventative Strategies and Individualized Therapy
title_fullStr A Shortcut from Metabolic-Associated Fatty Liver Disease (MAFLD) to Hepatocellular Carcinoma (HCC): c-MYC a Promising Target for Preventative Strategies and Individualized Therapy
title_full_unstemmed A Shortcut from Metabolic-Associated Fatty Liver Disease (MAFLD) to Hepatocellular Carcinoma (HCC): c-MYC a Promising Target for Preventative Strategies and Individualized Therapy
title_sort A Shortcut from Metabolic-Associated Fatty Liver Disease (MAFLD) to Hepatocellular Carcinoma (HCC): c-MYC a Promising Target for Preventative Strategies and Individualized Therapy
dc.creator.none.fl_str_mv Guo, Feifei
Estévez-Vázquez, Olga
Benedé-Ubieto, Raquel
Maya-Miles, Douglas
Zheng, Kang
Gallego-Durán, Rocío
Rojas, Ángela
Ampuero, Javier
Romero-Gómez, Manuel
Philip, Kaye
Egbuniwe, Isioma U.
Chen, Chaobo
Simon, Jorge
Delgado, Teresa C.
Martínez-Chantar, María Luz
Sun, Jie
Reissing, Johanna
Bruns, Tony
Lamas-Paz, Arantza
Gómez del Moral, Manuel
Woitok, Marius Maximilian
Vaquero, Javier
Regueiro, José R.
Liedtke, Christian
Trautwein, Christian
Bañares, Rafael
Cubero, Javier
Nevzorova, Yulia A.
author Guo, Feifei
author_facet Guo, Feifei
Estévez-Vázquez, Olga
Benedé-Ubieto, Raquel
Maya-Miles, Douglas
Zheng, Kang
Gallego-Durán, Rocío
Rojas, Ángela
Ampuero, Javier
Romero-Gómez, Manuel
Philip, Kaye
Egbuniwe, Isioma U.
Chen, Chaobo
Simon, Jorge
Delgado, Teresa C.
Martínez-Chantar, María Luz
Sun, Jie
Reissing, Johanna
Bruns, Tony
Lamas-Paz, Arantza
Gómez del Moral, Manuel
Woitok, Marius Maximilian
Vaquero, Javier
Regueiro, José R.
Liedtke, Christian
Trautwein, Christian
Bañares, Rafael
Cubero, Javier
Nevzorova, Yulia A.
author_role author
author2 Estévez-Vázquez, Olga
Benedé-Ubieto, Raquel
Maya-Miles, Douglas
Zheng, Kang
Gallego-Durán, Rocío
Rojas, Ángela
Ampuero, Javier
Romero-Gómez, Manuel
Philip, Kaye
Egbuniwe, Isioma U.
Chen, Chaobo
Simon, Jorge
Delgado, Teresa C.
Martínez-Chantar, María Luz
Sun, Jie
Reissing, Johanna
Bruns, Tony
Lamas-Paz, Arantza
Gómez del Moral, Manuel
Woitok, Marius Maximilian
Vaquero, Javier
Regueiro, José R.
Liedtke, Christian
Trautwein, Christian
Bañares, Rafael
Cubero, Javier
Nevzorova, Yulia A.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Comunidad de Madrid
Fundación Caixa Galicia
Universidad Complutense de Madrid
Asociación Española Contra el Cáncer
German Research Foundation
Gilead Research Scholars
China Scholarship Council
Banco Santander
Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (España)
Junta de Andalucía
Instituto de Salud Carlos III
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Tumorigenesis
C-myc
Metabolic-associated fatty liver disease
Metformin
Oncogene
topic Tumorigenesis
C-myc
Metabolic-associated fatty liver disease
Metformin
Oncogene
description Metabolic-associated fatty liver disease (MAFLD) has risen as one of the leading etiologies for hepatocellular carcinoma (HCC). Oncogenes have been suggested to be responsible for the high risk of MAFLD-related HCC. We analyzed the impact of the proto-oncogene c-MYC in the development of human and murine MAFLD and MAFLD-associated HCC.
publishDate 2021
dc.date.none.fl_str_mv 2021
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
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Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/296122
https://api.elsevier.com/content/abstract/scopus_id/85122071976
url http://hdl.handle.net/10261/296122
https://api.elsevier.com/content/abstract/scopus_id/85122071976
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
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Guo, Feifei; Estévez-Vázquez, Olga; Benedé-Ubieto, Raquel; Maya-Miles, Douglas; Zheng, Kang; Gallego-Durán, Rocío; Rojas, Ángela; Ampuero, Javier; Romero-Gómez, Manuel; Philip, Kaye; Egbuniwe, Isioma U.; Chen, Chaobo; Simon, Jorge; Delgado, Teresa C.; Martínez-Chantar, María Luz; Sun, Jie; Reissing, Johanna; Bruns, Tony; Lamas-Paz, Arantza; Gómez del Moral, Manuel; Woitok, Marius Maximilian; Vaquero, Javier; Regueiro, José R.; Liedtke, Christian; Trautwein, Christian; Bañares, Rafael; Cubero, Javier; Nevzorova, Yulia A.; 2021; Supplementary materials: A Shortcut from Metabolic-Associated Fatty Liver Disease (MAFLD) to Hepatocellular Carcinoma (HCC): c-MYC a Promising Target for Preventative Strategies and Individualized Therapy [Dataset]; Multidisciplinary Digital Publishing Institute; https://doi.org/10.3390/cancers14010192/s1
https://doi.org/10.3390/cancers14010192
Sí
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dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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spelling A Shortcut from Metabolic-Associated Fatty Liver Disease (MAFLD) to Hepatocellular Carcinoma (HCC): c-MYC a Promising Target for Preventative Strategies and Individualized TherapyGuo, FeifeiEstévez-Vázquez, OlgaBenedé-Ubieto, RaquelMaya-Miles, DouglasZheng, KangGallego-Durán, RocíoRojas, ÁngelaAmpuero, JavierRomero-Gómez, ManuelPhilip, KayeEgbuniwe, Isioma U.Chen, ChaoboSimon, JorgeDelgado, Teresa C.Martínez-Chantar, María LuzSun, JieReissing, JohannaBruns, TonyLamas-Paz, ArantzaGómez del Moral, ManuelWoitok, Marius MaximilianVaquero, JavierRegueiro, José R.Liedtke, ChristianTrautwein, ChristianBañares, RafaelCubero, JavierNevzorova, Yulia A.TumorigenesisC-mycMetabolic-associated fatty liver diseaseMetforminOncogeneMetabolic-associated fatty liver disease (MAFLD) has risen as one of the leading etiologies for hepatocellular carcinoma (HCC). Oncogenes have been suggested to be responsible for the high risk of MAFLD-related HCC. We analyzed the impact of the proto-oncogene c-MYC in the development of human and murine MAFLD and MAFLD-associated HCC.This work was supported by the MINECO Retos SAF2016-78711, SAF2017-87919-R, PID2020-117827RB-IOO, PID2020-117941RB-IOO, PID2020-117116RB-I00, EXOHEP-CM S2017/BMD-3727, NanoLiver-CM Y2018/NMT-4949, AMMF 2018/117, COST Action CA17112 and UCM-25/2019, La Caixa Foundation Program HR17-00601; Asociación Española Contra el Cáncer (AECC PROYE20084REGU); the German Research Foundation (SFB1382 Project ID 403224013/A02). FJC and YAN are Ramón y Cajal Researchers RYC-2014-15242 and RYC-2015-17438, respectively. FJC is a Gilead Liver Research Scholar. The research group belongs to the validated Research Groups Ref. 970935 “Liver Pathophysiology”, 920631 “Lymphocyte immunobiology”, 920361 “Inmunogenética e inmunología de las mucosas” and IBL-6 (imas12-associated). FG and KZ are Chinese Scholarship Council (CSC) fellows. O.E.-V is supported by Beca FPI associated to MINECO SAR2017-87919R and R.B.-U by programa de Financiación de Universidad Complutense de Madrid—Banco Santander, CT63/19. DMM contract is supported by CIBEREHD. DMM, MRG, AR, JA and RG receive support from the Andalusian government (Proyectos Estratégicos-Fondos Feder PE-0451-2018) and from the Instituto de Salud Carlos III (PI16/01842, PI19/01404; PI19/00589). TB is supported by the German Research Foundation (SFB1382 Project ID 403224013/B07).Peer reviewedMultidisciplinary Digital Publishing InstituteMinisterio de Economía y Competitividad (España)Comunidad de MadridFundación Caixa GaliciaUniversidad Complutense de MadridAsociación Española Contra el CáncerGerman Research FoundationGilead Research ScholarsChina Scholarship CouncilBanco SantanderCentro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (España)Junta de AndalucíaInstituto de Salud Carlos IIIConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202320232021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/296122https://api.elsevier.com/content/abstract/scopus_id/85122071976reponame:DIGITAL.CSIC. 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