A Shortcut from Metabolic-Associated Fatty Liver Disease (MAFLD) to Hepatocellular Carcinoma (HCC): c-MYC a Promising Target for Preventative Strategies and Individualized Therapy

Metabolic-associated fatty liver disease (MAFLD) has risen as one of the leading etiologies for hepatocellular carcinoma (HCC). Oncogenes have been suggested to be responsible for the high risk of MAFLD-related HCC. We analyzed the impact of the proto-oncogene c-MYC in the development of human and m...

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Detalles Bibliográficos
Autores: Guo, Feifei, Estévez-Vázquez, Olga, Benedé-Ubieto, Raquel, Maya-Miles, Douglas, Zheng, Kang, Gallego-Durán, Rocío, Rojas, Ángela, Ampuero, Javier, Romero-Gómez, Manuel, Philip, Kaye, Egbuniwe, Isioma U., Chen, Chaobo, Simon, Jorge, Delgado, Teresa C., Martínez-Chantar, María Luz, Sun, Jie, Reissing, Johanna, Bruns, Tony, Lamas-Paz, Arantza, Gómez del Moral, Manuel, Woitok, Marius Maximilian, Vaquero, Javier, Regueiro, José R., Liedtke, Christian, Trautwein, Christian, Bañares, Rafael, Cubero, Javier, Nevzorova, Yulia A.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/296122
Acceso en línea:http://hdl.handle.net/10261/296122
https://api.elsevier.com/content/abstract/scopus_id/85122071976
Access Level:acceso abierto
Palabra clave:Tumorigenesis
C-myc
Metabolic-associated fatty liver disease
Metformin
Oncogene
Descripción
Sumario:Metabolic-associated fatty liver disease (MAFLD) has risen as one of the leading etiologies for hepatocellular carcinoma (HCC). Oncogenes have been suggested to be responsible for the high risk of MAFLD-related HCC. We analyzed the impact of the proto-oncogene c-MYC in the development of human and murine MAFLD and MAFLD-associated HCC.

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