Efficacy of cognitive rehabilitation in cognition and brain networks: A randomised clinical trial in patients with multiple sclerosis

This study evaluated the efficacy of the computerised Guttmann, NeuroPersonalTrainer (R)(GNPT) cognitive rehabilitation (CR) and characterised the induced changes in cerebral networks in patients with multiple sclerosis (MS). This multicentre, double-blind, randomised clinical trial compared upward...

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Autores: Lopez-Soley, E, Martinez-Heras, E, Vivo, F, Calvi, A, Alba-Arbalat, S, Romero-Pinel, L, Martínez-Yélamos, S, Ramo-Tello, C, Presas-Rodríguez, S, Munteis, E, Martínez-Rodríguez, JE, Sastre-Garriga, J, Anglada, E, Meza-Murillo, ER, Arévalo, MJ, Sanchez-Carrión, R, Pelayo, R, Bernabeu, M, Sola-Valls, N, Hervas, M, Sepulveda, M, Saiz, A, Blanco, Y, Solana, E, Llufriu, S
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Institut d'Investigació i Innovació Parc Taulí (I3PT)
Repositorio:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
OAI Identifier:oai:i3pt.fundanetsuite.com:p6320
Acceso en línea:https://i3pt.portalinvestigacion.com/publicaciones/6320
Access Level:acceso abierto
Palabra clave:Cognitive rehabilitation
Cognition
MRI
Structural networks
Multiple sclerosis
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spelling Efficacy of cognitive rehabilitation in cognition and brain networks: A randomised clinical trial in patients with multiple sclerosisLopez-Soley, EMartinez-Heras, EVivo, FCalvi, AAlba-Arbalat, SRomero-Pinel, LMartínez-Yélamos, SRamo-Tello, CPresas-Rodríguez, SMunteis, EMartínez-Rodríguez, JESastre-Garriga, JAnglada, EMeza-Murillo, ERArévalo, MJSanchez-Carrión, RPelayo, RBernabeu, MSola-Valls, NHervas, MSepulveda, MSaiz, ABlanco, YSolana, ELlufriu, SCognitive rehabilitationCognitionMRIStructural networksMultiple sclerosisThis study evaluated the efficacy of the computerised Guttmann, NeuroPersonalTrainer (R)(GNPT) cognitive rehabilitation (CR) and characterised the induced changes in cerebral networks in patients with multiple sclerosis (MS). This multicentre, double-blind, randomised clinical trial compared upward intensity training (active treatment) to low-intensity static training (static treatment). Cognition was assessed using the Brief Repeatable battery before and after 12 weeks of training and at 10-months follow-up, and patients were classified as having a mild or severe cognitive impairment (CI). Brain MRI pre-and post-CR were analysed using an advanced tractography algorithm, based on multishell diffusion MRI, to obtain node-based graph metrics (local efficiency and strength) from microscopic fractional anisotropy. Seventy MS patients completed the study (age 48.9 +/- 8.8, disease duration 16.8 +/- 9.0 years); active treatment: 36, static treatment: 34. Verbal memory improved significantly post-CR in both groups (55 % active; 34 % static treatment), accompanied by increases in local efficiency and strength in multimodal regions. At follow-up, verbal memory declined in both groups but remained above the pre-CR assessment (-25 % and-17 %, respectively). Patients with severe-CI (n = 36) showed improvement only with active treatment, while those with mild-CI (n = 34) improved regardless of intensity treatment. Network changes were more pronounced in patients in active treatment and in those with severe-CI. Quality of life did not change at post-CR, and cognitive improvement was influenced by cognitive reserve (p = 0.011). In MS, GNPT temporarily improves verbal memory and increases network connectivity, reinforcing the CR as a valuable tool for enhancing cognitive skills and promoting neuronal plasticity.ELSEVIER SCI LTD2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://i3pt.portalinvestigacion.com/publicaciones/6320NeuroImage-ClinicalISSN: 22131582reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulíinstname:Institut d'Investigació i Innovació Parc Taulí (I3PT)Inglésinfo:eu-repo/semantics/openAccessoai:i3pt.fundanetsuite.com:p63202026-06-21T15:30:37Z
dc.title.none.fl_str_mv Efficacy of cognitive rehabilitation in cognition and brain networks: A randomised clinical trial in patients with multiple sclerosis
title Efficacy of cognitive rehabilitation in cognition and brain networks: A randomised clinical trial in patients with multiple sclerosis
spellingShingle Efficacy of cognitive rehabilitation in cognition and brain networks: A randomised clinical trial in patients with multiple sclerosis
Lopez-Soley, E
Cognitive rehabilitation
Cognition
MRI
Structural networks
Multiple sclerosis
title_short Efficacy of cognitive rehabilitation in cognition and brain networks: A randomised clinical trial in patients with multiple sclerosis
title_full Efficacy of cognitive rehabilitation in cognition and brain networks: A randomised clinical trial in patients with multiple sclerosis
title_fullStr Efficacy of cognitive rehabilitation in cognition and brain networks: A randomised clinical trial in patients with multiple sclerosis
title_full_unstemmed Efficacy of cognitive rehabilitation in cognition and brain networks: A randomised clinical trial in patients with multiple sclerosis
title_sort Efficacy of cognitive rehabilitation in cognition and brain networks: A randomised clinical trial in patients with multiple sclerosis
dc.creator.none.fl_str_mv Lopez-Soley, E
Martinez-Heras, E
Vivo, F
Calvi, A
Alba-Arbalat, S
Romero-Pinel, L
Martínez-Yélamos, S
Ramo-Tello, C
Presas-Rodríguez, S
Munteis, E
Martínez-Rodríguez, JE
Sastre-Garriga, J
Anglada, E
Meza-Murillo, ER
Arévalo, MJ
Sanchez-Carrión, R
Pelayo, R
Bernabeu, M
Sola-Valls, N
Hervas, M
Sepulveda, M
Saiz, A
Blanco, Y
Solana, E
Llufriu, S
author Lopez-Soley, E
author_facet Lopez-Soley, E
Martinez-Heras, E
Vivo, F
Calvi, A
Alba-Arbalat, S
Romero-Pinel, L
Martínez-Yélamos, S
Ramo-Tello, C
Presas-Rodríguez, S
Munteis, E
Martínez-Rodríguez, JE
Sastre-Garriga, J
Anglada, E
Meza-Murillo, ER
Arévalo, MJ
Sanchez-Carrión, R
Pelayo, R
Bernabeu, M
Sola-Valls, N
Hervas, M
Sepulveda, M
Saiz, A
Blanco, Y
Solana, E
Llufriu, S
author_role author
author2 Martinez-Heras, E
Vivo, F
Calvi, A
Alba-Arbalat, S
Romero-Pinel, L
Martínez-Yélamos, S
Ramo-Tello, C
Presas-Rodríguez, S
Munteis, E
Martínez-Rodríguez, JE
Sastre-Garriga, J
Anglada, E
Meza-Murillo, ER
Arévalo, MJ
Sanchez-Carrión, R
Pelayo, R
Bernabeu, M
Sola-Valls, N
Hervas, M
Sepulveda, M
Saiz, A
Blanco, Y
Solana, E
Llufriu, S
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cognitive rehabilitation
Cognition
MRI
Structural networks
Multiple sclerosis
topic Cognitive rehabilitation
Cognition
MRI
Structural networks
Multiple sclerosis
description This study evaluated the efficacy of the computerised Guttmann, NeuroPersonalTrainer (R)(GNPT) cognitive rehabilitation (CR) and characterised the induced changes in cerebral networks in patients with multiple sclerosis (MS). This multicentre, double-blind, randomised clinical trial compared upward intensity training (active treatment) to low-intensity static training (static treatment). Cognition was assessed using the Brief Repeatable battery before and after 12 weeks of training and at 10-months follow-up, and patients were classified as having a mild or severe cognitive impairment (CI). Brain MRI pre-and post-CR were analysed using an advanced tractography algorithm, based on multishell diffusion MRI, to obtain node-based graph metrics (local efficiency and strength) from microscopic fractional anisotropy. Seventy MS patients completed the study (age 48.9 +/- 8.8, disease duration 16.8 +/- 9.0 years); active treatment: 36, static treatment: 34. Verbal memory improved significantly post-CR in both groups (55 % active; 34 % static treatment), accompanied by increases in local efficiency and strength in multimodal regions. At follow-up, verbal memory declined in both groups but remained above the pre-CR assessment (-25 % and-17 %, respectively). Patients with severe-CI (n = 36) showed improvement only with active treatment, while those with mild-CI (n = 34) improved regardless of intensity treatment. Network changes were more pronounced in patients in active treatment and in those with severe-CI. Quality of life did not change at post-CR, and cognitive improvement was influenced by cognitive reserve (p = 0.011). In MS, GNPT temporarily improves verbal memory and increases network connectivity, reinforcing the CR as a valuable tool for enhancing cognitive skills and promoting neuronal plasticity.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://i3pt.portalinvestigacion.com/publicaciones/6320
url https://i3pt.portalinvestigacion.com/publicaciones/6320
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ELSEVIER SCI LTD
publisher.none.fl_str_mv ELSEVIER SCI LTD
dc.source.none.fl_str_mv NeuroImage-Clinical
ISSN: 22131582
reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
instname:Institut d'Investigació i Innovació Parc Taulí (I3PT)
instname_str Institut d'Investigació i Innovació Parc Taulí (I3PT)
reponame_str r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
collection r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
repository.name.fl_str_mv
repository.mail.fl_str_mv
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