Plasma irisin depletion under energy restriction is associated with improvements in lipid profile in metabolic syndrome patients

Objective A recently discovered myokine, irisin, may have an important role in energy metabolism. This study aimed to evaluate the relationship between this hormone and the lipid profile of Metabolic Syndrome (MetS) patients following a hypocaloric diet. Design Ninety-three Caucasian adults (52 men/...

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Autores: Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131, Zulet, M.A. (María Ángeles)|||/items/0a10c4f7-ed81-4b2e-bffe-fbcb7fccd239, Casanueva, F.F. (Felipe F.)|||/items/6e2fea43-337d-4897-84ed-7feead87f59f, Pardo, M. (M.)|||/items/e8a7e482-114c-43c8-84a7-f3893f07a0a2, Crujeiras, A.B. (Ana B.)|||/items/63af043e-dbbb-4859-a9a7-11317aadb9de, Lopez-Legarrea, P. (Patricia)|||/items/4783fc8c-2687-4fc4-84df-57e7662a8c57, Iglesia, R. (Rocío) de la|||/items/8f8a7cd3-8633-455e-a533-a4ce490c2aca
Tipo de recurso: artículo
Fecha de publicación:2014
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/35862
Acceso en línea:https://hdl.handle.net/10171/35862
Access Level:acceso abierto
Palabra clave:Apolipoprotein B
Cholesterol
Atherogenic
Hypocaloric
RESMENA
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repository_id_str
spelling Plasma irisin depletion under energy restriction is associated with improvements in lipid profile in metabolic syndrome patientsMartinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131Zulet, M.A. (María Ángeles)|||/items/0a10c4f7-ed81-4b2e-bffe-fbcb7fccd239Casanueva, F.F. (Felipe F.)|||/items/6e2fea43-337d-4897-84ed-7feead87f59fPardo, M. (M.)|||/items/e8a7e482-114c-43c8-84a7-f3893f07a0a2Crujeiras, A.B. (Ana B.)|||/items/63af043e-dbbb-4859-a9a7-11317aadb9deLopez-Legarrea, P. (Patricia)|||/items/4783fc8c-2687-4fc4-84df-57e7662a8c57Iglesia, R. (Rocío) de la|||/items/8f8a7cd3-8633-455e-a533-a4ce490c2acaApolipoprotein BCholesterolAtherogenicHypocaloricRESMENAObjective A recently discovered myokine, irisin, may have an important role in energy metabolism. This study aimed to evaluate the relationship between this hormone and the lipid profile of Metabolic Syndrome (MetS) patients following a hypocaloric diet. Design Ninety-three Caucasian adults (52 men/41 women) diagnosed with MetS followed an 8-week-long energy restricted programme (-30% of the energy requirements). Anthropometric measurements, biochemical markers and plasma irisin levels were analysed before and after the nutritional intervention. Results Global plasma irisin levels were significantly reduced at the end of the study (-72•0 ± 100•9 ng/mL, p < 0•001) accompanying the weight loss (-6•9%). The depletion of irisin significantly correlated with changes in some atherogenic-related variables: total cholesterol (B = 0•106, p = 0•018), total cholesterol/high density lipoprotein-cholesterol ratio (B = 0•002, p = 0•036), low density lipoprotein-cholesterol (B = 0•085, p = 0•037) and apolipoprotein B (B = 0•052, p = 0•002), independently of changes in body weight. Conclusions An association between the reduction of plasma irisin levels and the depletion of important lipid metabolism biomarkers was observed in patients with MetS undergoing an energy restricted programme.WileyDadun. Depósito Académico Digital Universidad de Navarra20142014-05-1420142014-01-0120142014-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/35862reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/358622026-06-21T12:47:57Z
dc.title.none.fl_str_mv Plasma irisin depletion under energy restriction is associated with improvements in lipid profile in metabolic syndrome patients
title Plasma irisin depletion under energy restriction is associated with improvements in lipid profile in metabolic syndrome patients
spellingShingle Plasma irisin depletion under energy restriction is associated with improvements in lipid profile in metabolic syndrome patients
Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131
Apolipoprotein B
Cholesterol
Atherogenic
Hypocaloric
RESMENA
title_short Plasma irisin depletion under energy restriction is associated with improvements in lipid profile in metabolic syndrome patients
title_full Plasma irisin depletion under energy restriction is associated with improvements in lipid profile in metabolic syndrome patients
title_fullStr Plasma irisin depletion under energy restriction is associated with improvements in lipid profile in metabolic syndrome patients
title_full_unstemmed Plasma irisin depletion under energy restriction is associated with improvements in lipid profile in metabolic syndrome patients
title_sort Plasma irisin depletion under energy restriction is associated with improvements in lipid profile in metabolic syndrome patients
dc.creator.none.fl_str_mv Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131
Zulet, M.A. (María Ángeles)|||/items/0a10c4f7-ed81-4b2e-bffe-fbcb7fccd239
Casanueva, F.F. (Felipe F.)|||/items/6e2fea43-337d-4897-84ed-7feead87f59f
Pardo, M. (M.)|||/items/e8a7e482-114c-43c8-84a7-f3893f07a0a2
Crujeiras, A.B. (Ana B.)|||/items/63af043e-dbbb-4859-a9a7-11317aadb9de
Lopez-Legarrea, P. (Patricia)|||/items/4783fc8c-2687-4fc4-84df-57e7662a8c57
Iglesia, R. (Rocío) de la|||/items/8f8a7cd3-8633-455e-a533-a4ce490c2aca
author Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131
author_facet Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131
Zulet, M.A. (María Ángeles)|||/items/0a10c4f7-ed81-4b2e-bffe-fbcb7fccd239
Casanueva, F.F. (Felipe F.)|||/items/6e2fea43-337d-4897-84ed-7feead87f59f
Pardo, M. (M.)|||/items/e8a7e482-114c-43c8-84a7-f3893f07a0a2
Crujeiras, A.B. (Ana B.)|||/items/63af043e-dbbb-4859-a9a7-11317aadb9de
Lopez-Legarrea, P. (Patricia)|||/items/4783fc8c-2687-4fc4-84df-57e7662a8c57
Iglesia, R. (Rocío) de la|||/items/8f8a7cd3-8633-455e-a533-a4ce490c2aca
author_role author
author2 Zulet, M.A. (María Ángeles)|||/items/0a10c4f7-ed81-4b2e-bffe-fbcb7fccd239
Casanueva, F.F. (Felipe F.)|||/items/6e2fea43-337d-4897-84ed-7feead87f59f
Pardo, M. (M.)|||/items/e8a7e482-114c-43c8-84a7-f3893f07a0a2
Crujeiras, A.B. (Ana B.)|||/items/63af043e-dbbb-4859-a9a7-11317aadb9de
Lopez-Legarrea, P. (Patricia)|||/items/4783fc8c-2687-4fc4-84df-57e7662a8c57
Iglesia, R. (Rocío) de la|||/items/8f8a7cd3-8633-455e-a533-a4ce490c2aca
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv Apolipoprotein B
Cholesterol
Atherogenic
Hypocaloric
RESMENA
topic Apolipoprotein B
Cholesterol
Atherogenic
Hypocaloric
RESMENA
description Objective A recently discovered myokine, irisin, may have an important role in energy metabolism. This study aimed to evaluate the relationship between this hormone and the lipid profile of Metabolic Syndrome (MetS) patients following a hypocaloric diet. Design Ninety-three Caucasian adults (52 men/41 women) diagnosed with MetS followed an 8-week-long energy restricted programme (-30% of the energy requirements). Anthropometric measurements, biochemical markers and plasma irisin levels were analysed before and after the nutritional intervention. Results Global plasma irisin levels were significantly reduced at the end of the study (-72•0 ± 100•9 ng/mL, p < 0•001) accompanying the weight loss (-6•9%). The depletion of irisin significantly correlated with changes in some atherogenic-related variables: total cholesterol (B = 0•106, p = 0•018), total cholesterol/high density lipoprotein-cholesterol ratio (B = 0•002, p = 0•036), low density lipoprotein-cholesterol (B = 0•085, p = 0•037) and apolipoprotein B (B = 0•052, p = 0•002), independently of changes in body weight. Conclusions An association between the reduction of plasma irisin levels and the depletion of important lipid metabolism biomarkers was observed in patients with MetS undergoing an energy restricted programme.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-05-14
2014
2014-01-01
2014
2014-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10171/35862
url https://hdl.handle.net/10171/35862
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra
instname:Universidad de Navarra
instname_str Universidad de Navarra
reponame_str Dadun. Depósito Académico Digital de la Universidad de Navarra
collection Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301629

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