Multiomic‐based immune response profiling in migraine, vestibular migraine and Meniere's disease

[EN]Migraine (MI) is the most common neurological disease, affecting with 20% of the world population. A subset of 25% of MI patients showcase concurrent vestibular symptoms, which may classify as vestibular migraine (VM). Meniere's disease (MD) is a complex inner ear disorder defined by episod...

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Autores: Cruz‐Granados, Pablo, Frejo, Lidia, Perez‐Carpena, Patricia, Amor‐Dorado, Juan Carlos, Dominguez‐Duran, Emilio, Fernandez‐Nava, Maria Jose, Batuecas Caletrio, Ángel, Haro‐Hernandez, Elisheba, Martinez‐Martinez, Marta, Lopez‐Escamez, Jose A.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Universidad de Salamanca (USAL)
Repositorio:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/163538
Acceso en línea:http://hdl.handle.net/10366/163538
Access Level:acceso abierto
Palabra clave:Meniere disease
Autoinflammation
Cytokines
Migraine
Monocytes
2412 Inmunología
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repository_id_str
spelling Multiomic‐based immune response profiling in migraine, vestibular migraine and Meniere's diseaseCruz‐Granados, PabloFrejo, LidiaPerez‐Carpena, PatriciaAmor‐Dorado, Juan CarlosDominguez‐Duran, EmilioFernandez‐Nava, Maria JoseBatuecas Caletrio, ÁngelHaro‐Hernandez, ElishebaMartinez‐Martinez, MartaLopez‐Escamez, Jose A.Meniere diseaseAutoinflammationCytokinesMigraineMonocytes2412 Inmunología[EN]Migraine (MI) is the most common neurological disease, affecting with 20% of the world population. A subset of 25% of MI patients showcase concurrent vestibular symptoms, which may classify as vestibular migraine (VM). Meniere's disease (MD) is a complex inner ear disorder defined by episodes of vertigo associated with tinnitus and sensorineural hearing loss with a significant autoimmune/autoinflammatory contribution, which symptoms overlap with VM. Blood samples from 18 patients with MI (5), VM (5) and MD (8) and 6 controls were collected and compared in a case–control study. Droplet-isolated nuclei from mononuclear cells used to generate scRNAseq and scATACseq data sets from MI, VM and MD. MI and VM have no differences in their immune transcriptome; therefore, they were considered as a single cluster for further analyses. Natural Killer (NK) cells transcriptomic data support a polarisation triggered by Type 1 innate immune cells via the release of interleukin (IL)-12, IL-15 and IL-18. According to the monocyte scRNAseq data, there were two MD clusters, one inactive and one driven by monocytes. The unique pathways of the MI + VM cluster were cellular responses to metal ions, whereas MD monocyte-driven cluster pathways showed responses to biotic stimuli. MI and MD have different immune responses. These findings support that MI and VM have a Type 1 immune lymphoid cell response, and that there are two clusters of MD patients, one inactive and one Monocyte-driven.wiley202520252024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10366/163538reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)Inglésinfo:eu-repo/semantics/openAccessoai:gredos.usal.es:10366/1635382026-06-07T06:28:51Z
dc.title.none.fl_str_mv Multiomic‐based immune response profiling in migraine, vestibular migraine and Meniere's disease
title Multiomic‐based immune response profiling in migraine, vestibular migraine and Meniere's disease
spellingShingle Multiomic‐based immune response profiling in migraine, vestibular migraine and Meniere's disease
Cruz‐Granados, Pablo
Meniere disease
Autoinflammation
Cytokines
Migraine
Monocytes
2412 Inmunología
title_short Multiomic‐based immune response profiling in migraine, vestibular migraine and Meniere's disease
title_full Multiomic‐based immune response profiling in migraine, vestibular migraine and Meniere's disease
title_fullStr Multiomic‐based immune response profiling in migraine, vestibular migraine and Meniere's disease
title_full_unstemmed Multiomic‐based immune response profiling in migraine, vestibular migraine and Meniere's disease
title_sort Multiomic‐based immune response profiling in migraine, vestibular migraine and Meniere's disease
dc.creator.none.fl_str_mv Cruz‐Granados, Pablo
Frejo, Lidia
Perez‐Carpena, Patricia
Amor‐Dorado, Juan Carlos
Dominguez‐Duran, Emilio
Fernandez‐Nava, Maria Jose
Batuecas Caletrio, Ángel
Haro‐Hernandez, Elisheba
Martinez‐Martinez, Marta
Lopez‐Escamez, Jose A.
author Cruz‐Granados, Pablo
author_facet Cruz‐Granados, Pablo
Frejo, Lidia
Perez‐Carpena, Patricia
Amor‐Dorado, Juan Carlos
Dominguez‐Duran, Emilio
Fernandez‐Nava, Maria Jose
Batuecas Caletrio, Ángel
Haro‐Hernandez, Elisheba
Martinez‐Martinez, Marta
Lopez‐Escamez, Jose A.
author_role author
author2 Frejo, Lidia
Perez‐Carpena, Patricia
Amor‐Dorado, Juan Carlos
Dominguez‐Duran, Emilio
Fernandez‐Nava, Maria Jose
Batuecas Caletrio, Ángel
Haro‐Hernandez, Elisheba
Martinez‐Martinez, Marta
Lopez‐Escamez, Jose A.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Meniere disease
Autoinflammation
Cytokines
Migraine
Monocytes
2412 Inmunología
topic Meniere disease
Autoinflammation
Cytokines
Migraine
Monocytes
2412 Inmunología
description [EN]Migraine (MI) is the most common neurological disease, affecting with 20% of the world population. A subset of 25% of MI patients showcase concurrent vestibular symptoms, which may classify as vestibular migraine (VM). Meniere's disease (MD) is a complex inner ear disorder defined by episodes of vertigo associated with tinnitus and sensorineural hearing loss with a significant autoimmune/autoinflammatory contribution, which symptoms overlap with VM. Blood samples from 18 patients with MI (5), VM (5) and MD (8) and 6 controls were collected and compared in a case–control study. Droplet-isolated nuclei from mononuclear cells used to generate scRNAseq and scATACseq data sets from MI, VM and MD. MI and VM have no differences in their immune transcriptome; therefore, they were considered as a single cluster for further analyses. Natural Killer (NK) cells transcriptomic data support a polarisation triggered by Type 1 innate immune cells via the release of interleukin (IL)-12, IL-15 and IL-18. According to the monocyte scRNAseq data, there were two MD clusters, one inactive and one driven by monocytes. The unique pathways of the MI + VM cluster were cellular responses to metal ions, whereas MD monocyte-driven cluster pathways showed responses to biotic stimuli. MI and MD have different immune responses. These findings support that MI and VM have a Type 1 immune lymphoid cell response, and that there are two clusters of MD patients, one inactive and one Monocyte-driven.
publishDate 2024
dc.date.none.fl_str_mv 2024
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10366/163538
url http://hdl.handle.net/10366/163538
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv wiley
publisher.none.fl_str_mv wiley
dc.source.none.fl_str_mv reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname:Universidad de Salamanca (USAL)
instname_str Universidad de Salamanca (USAL)
reponame_str GREDOS. Repositorio Institucional de la Universidad de Salamanca
collection GREDOS. Repositorio Institucional de la Universidad de Salamanca
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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