Network interdigitations of Tau and amyloid-beta deposits define cognitive levels in aging

Amyloid-beta (A beta) plaques and tau neurofibrillary tangles are pathological hallmarks of Alzheimer's disease (AD); their contribution to neurodegeneration and clinical manifestations are critical in understanding preclinical AD. At present, the mechanisms related to A beta and tau pathogenes...

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Detalhes bibliográficos
Autores: Kim, CM, Montal, V, Diez, I, Orwig, W, Sepulcre, J, Alzheimer's Dis Neuroimaging
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2021
País:España
Recursos:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositório:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p4733
Acesso em linha:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4733
https://ddd.uab.cat/record/243795
Access Level:Acceso aberto
Palavra-chave:aging
Alzheimer&apos
s disease
amyloid PET
cognition
connectivity analysis
Tau PET
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spelling Network interdigitations of Tau and amyloid-beta deposits define cognitive levels in agingKim, CMMontal, VDiez, IOrwig, WSepulcre, JAlzheimer's Dis NeuroimagingagingAlzheimer&aposs diseaseamyloid PETcognitionconnectivity analysisTau PETAmyloid-beta (A beta) plaques and tau neurofibrillary tangles are pathological hallmarks of Alzheimer's disease (AD); their contribution to neurodegeneration and clinical manifestations are critical in understanding preclinical AD. At present, the mechanisms related to A beta and tau pathogenesis leading to cognitive decline in older adults remain largely unknown. Here, we examined graph theory-based positron emission tomography (PET) analytical approaches, within and between tau and A beta PET modalities, and tested the effects on cognitive changes in cognitively normal older adults (CN). Particularly, we focused on the network interdigitations of A beta and tau deposits, along with cognitive test scores in CN at both baseline and 2-year follow-up (FU). We found highly significant A beta-tau network integrations in AD vulnerable areas, as well as significant associations between those A beta-tau interdigitations and general cognitive impairment in CN at baseline and FU. Our findings suggest a distinctive contribution of interlinking network relationships between A beta and tau deposits in heteromodal areas of the human brain. They support a network-based interaction between A beta and tau accumulations as a key factor for cognitive deterioration in CN prior to dementia.WILEY2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4733https://ddd.uab.cat/record/243795HUMAN BRAIN MAPPINGISSN: 10659471ISSNe: 10970193reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p47332026-06-14T12:41:47Z
dc.title.none.fl_str_mv Network interdigitations of Tau and amyloid-beta deposits define cognitive levels in aging
title Network interdigitations of Tau and amyloid-beta deposits define cognitive levels in aging
spellingShingle Network interdigitations of Tau and amyloid-beta deposits define cognitive levels in aging
Kim, CM
aging
Alzheimer&apos
s disease
amyloid PET
cognition
connectivity analysis
Tau PET
title_short Network interdigitations of Tau and amyloid-beta deposits define cognitive levels in aging
title_full Network interdigitations of Tau and amyloid-beta deposits define cognitive levels in aging
title_fullStr Network interdigitations of Tau and amyloid-beta deposits define cognitive levels in aging
title_full_unstemmed Network interdigitations of Tau and amyloid-beta deposits define cognitive levels in aging
title_sort Network interdigitations of Tau and amyloid-beta deposits define cognitive levels in aging
dc.creator.none.fl_str_mv Kim, CM
Montal, V
Diez, I
Orwig, W
Sepulcre, J
Alzheimer's Dis Neuroimaging
author Kim, CM
author_facet Kim, CM
Montal, V
Diez, I
Orwig, W
Sepulcre, J
Alzheimer's Dis Neuroimaging
author_role author
author2 Montal, V
Diez, I
Orwig, W
Sepulcre, J
Alzheimer's Dis Neuroimaging
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv aging
Alzheimer&apos
s disease
amyloid PET
cognition
connectivity analysis
Tau PET
topic aging
Alzheimer&apos
s disease
amyloid PET
cognition
connectivity analysis
Tau PET
description Amyloid-beta (A beta) plaques and tau neurofibrillary tangles are pathological hallmarks of Alzheimer's disease (AD); their contribution to neurodegeneration and clinical manifestations are critical in understanding preclinical AD. At present, the mechanisms related to A beta and tau pathogenesis leading to cognitive decline in older adults remain largely unknown. Here, we examined graph theory-based positron emission tomography (PET) analytical approaches, within and between tau and A beta PET modalities, and tested the effects on cognitive changes in cognitively normal older adults (CN). Particularly, we focused on the network interdigitations of A beta and tau deposits, along with cognitive test scores in CN at both baseline and 2-year follow-up (FU). We found highly significant A beta-tau network integrations in AD vulnerable areas, as well as significant associations between those A beta-tau interdigitations and general cognitive impairment in CN at baseline and FU. Our findings suggest a distinctive contribution of interlinking network relationships between A beta and tau deposits in heteromodal areas of the human brain. They support a network-based interaction between A beta and tau accumulations as a key factor for cognitive deterioration in CN prior to dementia.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4733
https://ddd.uab.cat/record/243795
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4733
https://ddd.uab.cat/record/243795
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv WILEY
publisher.none.fl_str_mv WILEY
dc.source.none.fl_str_mv HUMAN BRAIN MAPPING
ISSN: 10659471
ISSNe: 10970193
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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