Differential Detection of Amyloid Aggregates in Old Animals Using Gold Nanorods by Computerized Tomography: A Pharmacokinetic and Bioaccumulation Study

The development of new materials and tools for radiology is key to the implementation of this diagnostic technique in clinics. In this work, we evaluated the differential accumulation of peptide-functionalized GNRs in a transgenic animal model (APPswe/PSENd1E9) of Alzheimer's disease (AD) by co...

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Detalles Bibliográficos
Autores: Jara-Guajardo, Pedro, Morales-Zavala, Francisco, Bolaños, Karen, Giralt, Ernest, Araya, Eyleen, Acosta, Gerardo A., Albericio, Fernando, Alvarez, Alejandra R., Kogan, Marcelo J.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/342384
Acceso en línea:http://hdl.handle.net/10261/342384
https://api.elsevier.com/content/abstract/scopus_id/85181448309
Access Level:acceso abierto
Palabra clave:Gold nanorods
Alzheimer’s disease
Aβ
amyloid-beta
Computed tomography
Diagnostic
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
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spelling Differential Detection of Amyloid Aggregates in Old Animals Using Gold Nanorods by Computerized Tomography: A Pharmacokinetic and Bioaccumulation StudyJara-Guajardo, PedroMorales-Zavala, FranciscoBolaños, KarenGiralt, ErnestAraya, EyleenAcosta, Gerardo A.Albericio, FernandoAlvarez, Alejandra R.Kogan, Marcelo J.Gold nanorodsAlzheimer’s diseaseAβamyloid-betaComputed tomographyDiagnostichttp://metadata.un.org/sdg/3Ensure healthy lives and promote well-being for all at all agesThe development of new materials and tools for radiology is key to the implementation of this diagnostic technique in clinics. In this work, we evaluated the differential accumulation of peptide-functionalized GNRs in a transgenic animal model (APPswe/PSENd1E9) of Alzheimer's disease (AD) by computed tomography (CT) and measured the pharmacokinetic parameters and bioaccumulation of the nanosystem.We thank Plataforma Experimental Bio-CT, Faculty of Dentistry from Universidad de Chile (FONDEQUIP EQM150010) for performing the Micro-CT analysis. We thank Dr. Javier Morales Montecinos for the assessment of the pharmacokinetic studies. Peptide synthesis was performed at the NANBIOSIS–CIBER BBN Peptide Synthesis Unit (U3).This study was funded by the following projects: FONDECYT 1211482 (MK), FONDEQUIP EQM170111, FONDAP 15130011 (MK), Anillo ACT 210068, Beca Doctorado 21180739 (PJ), FONDECYT 3190547 (FM), FONDECYT 3220587 (KB), FONDECYT 1201668 (AA), FONDEF ID21I10347 (AA), and Program ICM-ANID-ICN2021 045 (AA).Peer reviewedTaylor & FrancisConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/342384https://api.elsevier.com/content/abstract/scopus_id/85181448309reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésInternational journal of nanomedicinehttps://doi.org/10.2147/IJN.S435472Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3423842026-05-22T06:33:51Z
dc.title.none.fl_str_mv Differential Detection of Amyloid Aggregates in Old Animals Using Gold Nanorods by Computerized Tomography: A Pharmacokinetic and Bioaccumulation Study
title Differential Detection of Amyloid Aggregates in Old Animals Using Gold Nanorods by Computerized Tomography: A Pharmacokinetic and Bioaccumulation Study
spellingShingle Differential Detection of Amyloid Aggregates in Old Animals Using Gold Nanorods by Computerized Tomography: A Pharmacokinetic and Bioaccumulation Study
Jara-Guajardo, Pedro
Gold nanorods
Alzheimer’s disease
Aβ
amyloid-beta
Computed tomography
Diagnostic
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
title_short Differential Detection of Amyloid Aggregates in Old Animals Using Gold Nanorods by Computerized Tomography: A Pharmacokinetic and Bioaccumulation Study
title_full Differential Detection of Amyloid Aggregates in Old Animals Using Gold Nanorods by Computerized Tomography: A Pharmacokinetic and Bioaccumulation Study
title_fullStr Differential Detection of Amyloid Aggregates in Old Animals Using Gold Nanorods by Computerized Tomography: A Pharmacokinetic and Bioaccumulation Study
title_full_unstemmed Differential Detection of Amyloid Aggregates in Old Animals Using Gold Nanorods by Computerized Tomography: A Pharmacokinetic and Bioaccumulation Study
title_sort Differential Detection of Amyloid Aggregates in Old Animals Using Gold Nanorods by Computerized Tomography: A Pharmacokinetic and Bioaccumulation Study
dc.creator.none.fl_str_mv Jara-Guajardo, Pedro
Morales-Zavala, Francisco
Bolaños, Karen
Giralt, Ernest
Araya, Eyleen
Acosta, Gerardo A.
Albericio, Fernando
Alvarez, Alejandra R.
Kogan, Marcelo J.
author Jara-Guajardo, Pedro
author_facet Jara-Guajardo, Pedro
Morales-Zavala, Francisco
Bolaños, Karen
Giralt, Ernest
Araya, Eyleen
Acosta, Gerardo A.
Albericio, Fernando
Alvarez, Alejandra R.
Kogan, Marcelo J.
author_role author
author2 Morales-Zavala, Francisco
Bolaños, Karen
Giralt, Ernest
Araya, Eyleen
Acosta, Gerardo A.
Albericio, Fernando
Alvarez, Alejandra R.
Kogan, Marcelo J.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Gold nanorods
Alzheimer’s disease
Aβ
amyloid-beta
Computed tomography
Diagnostic
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
topic Gold nanorods
Alzheimer’s disease
Aβ
amyloid-beta
Computed tomography
Diagnostic
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
description The development of new materials and tools for radiology is key to the implementation of this diagnostic technique in clinics. In this work, we evaluated the differential accumulation of peptide-functionalized GNRs in a transgenic animal model (APPswe/PSENd1E9) of Alzheimer's disease (AD) by computed tomography (CT) and measured the pharmacokinetic parameters and bioaccumulation of the nanosystem.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/342384
https://api.elsevier.com/content/abstract/scopus_id/85181448309
url http://hdl.handle.net/10261/342384
https://api.elsevier.com/content/abstract/scopus_id/85181448309
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv International journal of nanomedicine
https://doi.org/10.2147/IJN.S435472
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869405784585011200
score 15,811543

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