Differential Detection of Amyloid Aggregates in Old Animals Using Gold Nanorods by Computerized Tomography: A Pharmacokinetic and Bioaccumulation Study

The development of new materials and tools for radiology is key to the implementation of this diagnostic technique in clinics. In this work, we evaluated the differential accumulation of peptide-functionalized GNRs in a transgenic animal model (APPswe/PSENd1E9) of Alzheimer's disease (AD) by co...

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Detalles Bibliográficos
Autores: Jara-Guajardo, Pedro, Morales-Zavala, Francisco, Bolaños, Karen, Giralt, Ernest, Araya, Eyleen, Acosta, Gerardo A., Albericio, Fernando, Alvarez, Alejandra R., Kogan, Marcelo J.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/342384
Acceso en línea:http://hdl.handle.net/10261/342384
https://api.elsevier.com/content/abstract/scopus_id/85181448309
Access Level:acceso abierto
Palabra clave:Gold nanorods
Alzheimer’s disease
Aβ
amyloid-beta
Computed tomography
Diagnostic
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Descripción
Sumario:The development of new materials and tools for radiology is key to the implementation of this diagnostic technique in clinics. In this work, we evaluated the differential accumulation of peptide-functionalized GNRs in a transgenic animal model (APPswe/PSENd1E9) of Alzheimer's disease (AD) by computed tomography (CT) and measured the pharmacokinetic parameters and bioaccumulation of the nanosystem.

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