Polymeric nanocapsules loaded with poly(I:C) and resiquimod to reprogram tumor-associated macrophages for the treatment of solid tumors

Anfray, Clément; Fernández Varela, Carmen; Ummarino, Aldo; Maeda, Akihiro; Sironi, Marina; Gandoy, Sara; Brea Floriani, José Manuel; Loza García, María Isabel; León, Sergio; Calvo, Alfonso; Correa Chinea, Juan Francisco; Fernández Megía, Eduardo; Alonso Fernández, María José; Allavena, Paola; Crecente Campo, José; Torres Andón, Fernando

Polymeric nanocapsules loaded with poly(I:C) and resiquimod to reprogram tumor-associated macrophages for the treatment of solid tumors

In the tumor microenvironment (TME), tumor-associated macrophages (TAMs) play a key immunosuppressive role that limits the ability of the immune system to fight cancer. Toll-like receptors (TLRs) ligands, such as poly(I:C) or resiquimod (R848) are able to reprogram TAMs towards M1-like antitumor eff...

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Detalles Bibliográficos
Autores:	Anfray, Clément, Fernández Varela, Carmen, Ummarino, Aldo, Maeda, Akihiro, Sironi, Marina, Gandoy, Sara, Brea Floriani, José Manuel, Loza García, María Isabel, León, Sergio, Calvo, Alfonso, Correa Chinea, Juan Francisco, Fernández Megía, Eduardo, Alonso Fernández, María José, Allavena, Paola, Crecente Campo, José, Torres Andón, Fernando
Tipo de recurso:	artículo
Fecha de publicación:	2024
País:	España
Institución:	Universidad de Santiago de Compostela (USC)
Repositorio:	Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:	inglés
OAI Identifier:	oai:minerva.usc.gal:10347/43311
Acceso en línea:	https://hdl.handle.net/10347/43311
Access Level:	acceso abierto
Palabra clave:	Polymeric nanocapsules Poly(I:C) Resiquimod (R848) Tumor-associated macrophages (TAMs) Toll-like receptor (TLR) Antitumoral immunotherapy Immunotoxicology Cancer 2306 Química orgánica

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network_name_str	España
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spelling	Polymeric nanocapsules loaded with poly(I:C) and resiquimod to reprogram tumor-associated macrophages for the treatment of solid tumorsAnfray, ClémentFernández Varela, CarmenUmmarino, AldoMaeda, AkihiroSironi, MarinaGandoy, SaraBrea Floriani, José ManuelLoza García, María IsabelLeón, SergioCalvo, AlfonsoCorrea Chinea, Juan FranciscoFernández Megía, EduardoAlonso Fernández, María JoséAllavena, PaolaCrecente Campo, JoséTorres Andón, FernandoPolymeric nanocapsulesPoly(I:C)Resiquimod (R848)Tumor-associated macrophages (TAMs)Toll-like receptor (TLR)Antitumoral immunotherapyImmunotoxicologyCancer2306 Química orgánicaIn the tumor microenvironment (TME), tumor-associated macrophages (TAMs) play a key immunosuppressive role that limits the ability of the immune system to fight cancer. Toll-like receptors (TLRs) ligands, such as poly(I:C) or resiquimod (R848) are able to reprogram TAMs towards M1-like antitumor effector cells. The objective of our work has been to develop and evaluate polymeric nanocapsules (NCs) loaded with poly(I:C)+R848, to improve drug stability and systemic toxicity, and evaluate their targeting and therapeutic activity towards TAMs in the TME of solid tumorsFrontiersUniversidade de Santiago de Compostela. Departamento de Química OrgánicaUniversidade de Santiago de Compostela. Centro de Investigación en Medicina Molecular e Enfermidades Crónicas (CiMUS)Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS)20242024-01-0820242024-01-08journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10347/43311reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:minerva.usc.gal:10347/433112026-06-15T12:47:27Z
dc.title.none.fl_str_mv	Polymeric nanocapsules loaded with poly(I:C) and resiquimod to reprogram tumor-associated macrophages for the treatment of solid tumors
title	Polymeric nanocapsules loaded with poly(I:C) and resiquimod to reprogram tumor-associated macrophages for the treatment of solid tumors
spellingShingle	Polymeric nanocapsules loaded with poly(I:C) and resiquimod to reprogram tumor-associated macrophages for the treatment of solid tumors Anfray, Clément Polymeric nanocapsules Poly(I:C) Resiquimod (R848) Tumor-associated macrophages (TAMs) Toll-like receptor (TLR) Antitumoral immunotherapy Immunotoxicology Cancer 2306 Química orgánica
title_short	Polymeric nanocapsules loaded with poly(I:C) and resiquimod to reprogram tumor-associated macrophages for the treatment of solid tumors
title_full	Polymeric nanocapsules loaded with poly(I:C) and resiquimod to reprogram tumor-associated macrophages for the treatment of solid tumors
title_fullStr	Polymeric nanocapsules loaded with poly(I:C) and resiquimod to reprogram tumor-associated macrophages for the treatment of solid tumors
title_full_unstemmed	Polymeric nanocapsules loaded with poly(I:C) and resiquimod to reprogram tumor-associated macrophages for the treatment of solid tumors
title_sort	Polymeric nanocapsules loaded with poly(I:C) and resiquimod to reprogram tumor-associated macrophages for the treatment of solid tumors
dc.creator.none.fl_str_mv	Anfray, Clément Fernández Varela, Carmen Ummarino, Aldo Maeda, Akihiro Sironi, Marina Gandoy, Sara Brea Floriani, José Manuel Loza García, María Isabel León, Sergio Calvo, Alfonso Correa Chinea, Juan Francisco Fernández Megía, Eduardo Alonso Fernández, María José Allavena, Paola Crecente Campo, José Torres Andón, Fernando
author	Anfray, Clément
author_facet	Anfray, Clément Fernández Varela, Carmen Ummarino, Aldo Maeda, Akihiro Sironi, Marina Gandoy, Sara Brea Floriani, José Manuel Loza García, María Isabel León, Sergio Calvo, Alfonso Correa Chinea, Juan Francisco Fernández Megía, Eduardo Alonso Fernández, María José Allavena, Paola Crecente Campo, José Torres Andón, Fernando
author_role	author
author2	Fernández Varela, Carmen Ummarino, Aldo Maeda, Akihiro Sironi, Marina Gandoy, Sara Brea Floriani, José Manuel Loza García, María Isabel León, Sergio Calvo, Alfonso Correa Chinea, Juan Francisco Fernández Megía, Eduardo Alonso Fernández, María José Allavena, Paola Crecente Campo, José Torres Andón, Fernando
author2_role	author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Universidade de Santiago de Compostela. Departamento de Química Orgánica Universidade de Santiago de Compostela. Centro de Investigación en Medicina Molecular e Enfermidades Crónicas (CiMUS) Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS)
dc.subject.none.fl_str_mv	Polymeric nanocapsules Poly(I:C) Resiquimod (R848) Tumor-associated macrophages (TAMs) Toll-like receptor (TLR) Antitumoral immunotherapy Immunotoxicology Cancer 2306 Química orgánica
topic	Polymeric nanocapsules Poly(I:C) Resiquimod (R848) Tumor-associated macrophages (TAMs) Toll-like receptor (TLR) Antitumoral immunotherapy Immunotoxicology Cancer 2306 Química orgánica
description	In the tumor microenvironment (TME), tumor-associated macrophages (TAMs) play a key immunosuppressive role that limits the ability of the immune system to fight cancer. Toll-like receptors (TLRs) ligands, such as poly(I:C) or resiquimod (R848) are able to reprogram TAMs towards M1-like antitumor effector cells. The objective of our work has been to develop and evaluate polymeric nanocapsules (NCs) loaded with poly(I:C)+R848, to improve drug stability and systemic toxicity, and evaluate their targeting and therapeutic activity towards TAMs in the TME of solid tumors
publishDate	2024
dc.date.none.fl_str_mv	2024 2024-01-08 2024 2024-01-08
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/10347/43311
url	https://hdl.handle.net/10347/43311
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Frontiers
publisher.none.fl_str_mv	Frontiers
dc.source.none.fl_str_mv	reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela instname:Universidad de Santiago de Compostela (USC)
instname_str	Universidad de Santiago de Compostela (USC)
reponame_str	Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection	Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15.811543

Polymeric nanocapsules loaded with poly(I:C) and resiquimod to reprogram tumor-associated macrophages for the treatment of solid tumors

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