Polymeric nanocapsules loaded with poly(I:C) and resiquimod to reprogram tumor-associated macrophages for the treatment of solid tumors

In the tumor microenvironment (TME), tumor-associated macrophages (TAMs) play a key immunosuppressive role that limits the ability of the immune system to fight cancer. Toll-like receptors (TLRs) ligands, such as poly(I:C) or resiquimod (R848) are able to reprogram TAMs towards M1-like antitumor eff...

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Detalles Bibliográficos
Autores: Anfray, Clément, Fernández Varela, Carmen, Ummarino, Aldo, Maeda, Akihiro, Sironi, Marina, Gandoy, Sara, Brea Floriani, José Manuel, Loza García, María Isabel, León, Sergio, Calvo, Alfonso, Correa Chinea, Juan Francisco, Fernández Megía, Eduardo, Alonso Fernández, María José, Allavena, Paola, Crecente Campo, José, Torres Andón, Fernando
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/43311
Acceso en línea:https://hdl.handle.net/10347/43311
Access Level:acceso abierto
Palabra clave:Polymeric nanocapsules
Poly(I:C)
Resiquimod (R848)
Tumor-associated macrophages (TAMs)
Toll-like receptor (TLR)
Antitumoral immunotherapy
Immunotoxicology
Cancer
2306 Química orgánica
Descripción
Sumario:In the tumor microenvironment (TME), tumor-associated macrophages (TAMs) play a key immunosuppressive role that limits the ability of the immune system to fight cancer. Toll-like receptors (TLRs) ligands, such as poly(I:C) or resiquimod (R848) are able to reprogram TAMs towards M1-like antitumor effector cells. The objective of our work has been to develop and evaluate polymeric nanocapsules (NCs) loaded with poly(I:C)+R848, to improve drug stability and systemic toxicity, and evaluate their targeting and therapeutic activity towards TAMs in the TME of solid tumors

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