Deletions and rearrangements of cyclin-dependent kinase 4 inhibitor gene p16 are associated with poor prognosis in B cell non-Hodgkin’s lymphomas
Fue un artículo que incidió en el mal pronóstico de los pacientes con linfoma que tenían deleción del gen p16, también denominado Multitumor Supressor-1 (MTS-1) mieloma hiperdiploide, identificando un pequeño grupo de pacientes que debería recibir un tratamiento seleccionado. Estos resultados han si...
| Autores: | , , , , , , , |
|---|---|
| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 1997 |
| País: | España |
| Recursos: | Universidad de Salamanca (USAL) |
| Repositorio: | GREDOS. Repositorio Institucional de la Universidad de Salamanca |
| OAI Identifier: | oai:gredos.usal.es:10366/155212 |
| Acesso em linha: | http://hdl.handle.net/10366/155212 |
| Access Level: | acceso embargado |
| Palavra-chave: | Myeloma p16 CDK4 Rarrangement Deletion Immunophenotyping Gene Deletion Adult Chromosome Deletion Humans Genes Prognosis Lymphoma Multiple Myeloma Mutation Gene Rearrangement Survival Analysis Cyclin-Dependent Kinase Inhibitor p16 3207.08 Hematología linfoma humanos mutación deleción génica mieloma múltiple inhibidor p16 de cinasas dependientes de ciclinas reordenamiento génico genes inmunofenotipificación pronóstico deleción cromosómica adulto análisis de supervivencia |
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Deletions and rearrangements of cyclin-dependent kinase 4 inhibitor gene p16 are associated with poor prognosis in B cell non-Hodgkin’s lymphomasGarcía Sanz, RamónGonzález Díaz, MarcosVargas, MChillón Santos, María del CarmenBalanzategui, ABarbón, MFlores, M TSan Miguel Izquierdo, Jesús FernandoMyelomap16CDK4RarrangementDeletionImmunophenotypingGene DeletionAdultChromosome DeletionHumansGenesPrognosisLymphomaMultiple MyelomaMutationGene RearrangementSurvival AnalysisCyclin-Dependent Kinase Inhibitor p163207.08 Hematologíalinfomahumanosmutacióndeleción génicamieloma múltipleinhibidor p16 de cinasas dependientes de ciclinasreordenamiento génicogenesinmunofenotipificaciónpronósticodeleción cromosómicaadultoanálisis de supervivenciaFue un artículo que incidió en el mal pronóstico de los pacientes con linfoma que tenían deleción del gen p16, también denominado Multitumor Supressor-1 (MTS-1) mieloma hiperdiploide, identificando un pequeño grupo de pacientes que debería recibir un tratamiento seleccionado. Estos resultados han sido confirmados luego con otras metodologías y el marcador pronóstico ha sido validado para otros propósitos.[EN]In the present study we examined by southern blot analysis the presence of deletions and rearrangements of the p16 tumour-supressor gene in B-cell Non-HodgkinÕs Lymphomas (NHLs) in order to determine wether or not these changes can be related with a particular histological subtype and the different clinico-biological and prognostic characteristics of the disease. 103 untreated patients were enrolled in the study. Seven cases displayed alterations in the p16 gene: four cases with homozygous deletions and three with gene rearrangement. The presence of these abnormalities did not correlate with any specific histological subtype: three cases were small lymphocytic lymphomas (two of them reclassified as mantle cell lymphoma on the basis of the REAL classification), two diffuse large cell lymphomas and two small non-cleaved cell lymphomas (one of them considered to be a Burkitt-like lymphoma according to the REAL). These seven cases showed a trend towards worse prognostic indicators than the remaining patients, an this was confirmed in the survival analysis, since the presence of p16 gene abnormalities was associated with a shorter survival (10 vs 81 months, p=0.0006). In the multivariate analysis, p16 abnormalities were selected as an independent prognostic factor together with the LDH and b2microglobulin. These findings support a role for the p16 gene in the pathogenesis of B-cell NHLs and suggest an association of p16 abnormalities with aggresive forms of the disease that could be useful to predict the prognosis of patients.Hospital Universitario de Salamanca Universidad de SalamancaHospital Universitario de SalamancaSpringer Natureinfo202420241997info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10366/155212reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)InglésFIS-SS 94/1564FIS-SS 96/1233Attribution-NonCommercial-NoDerivatives 4.0 Internacionalinfo:eu-repo/semantics/embargoedAccessoai:gredos.usal.es:10366/1552122026-06-07T06:28:51Z |
| dc.title.none.fl_str_mv |
Deletions and rearrangements of cyclin-dependent kinase 4 inhibitor gene p16 are associated with poor prognosis in B cell non-Hodgkin’s lymphomas |
| title |
Deletions and rearrangements of cyclin-dependent kinase 4 inhibitor gene p16 are associated with poor prognosis in B cell non-Hodgkin’s lymphomas |
| spellingShingle |
Deletions and rearrangements of cyclin-dependent kinase 4 inhibitor gene p16 are associated with poor prognosis in B cell non-Hodgkin’s lymphomas García Sanz, Ramón Myeloma p16 CDK4 Rarrangement Deletion Immunophenotyping Gene Deletion Adult Chromosome Deletion Humans Genes Prognosis Lymphoma Multiple Myeloma Mutation Gene Rearrangement Survival Analysis Cyclin-Dependent Kinase Inhibitor p16 3207.08 Hematología linfoma humanos mutación deleción génica mieloma múltiple inhibidor p16 de cinasas dependientes de ciclinas reordenamiento génico genes inmunofenotipificación pronóstico deleción cromosómica adulto análisis de supervivencia |
| title_short |
Deletions and rearrangements of cyclin-dependent kinase 4 inhibitor gene p16 are associated with poor prognosis in B cell non-Hodgkin’s lymphomas |
| title_full |
Deletions and rearrangements of cyclin-dependent kinase 4 inhibitor gene p16 are associated with poor prognosis in B cell non-Hodgkin’s lymphomas |
| title_fullStr |
Deletions and rearrangements of cyclin-dependent kinase 4 inhibitor gene p16 are associated with poor prognosis in B cell non-Hodgkin’s lymphomas |
| title_full_unstemmed |
Deletions and rearrangements of cyclin-dependent kinase 4 inhibitor gene p16 are associated with poor prognosis in B cell non-Hodgkin’s lymphomas |
| title_sort |
Deletions and rearrangements of cyclin-dependent kinase 4 inhibitor gene p16 are associated with poor prognosis in B cell non-Hodgkin’s lymphomas |
| dc.creator.none.fl_str_mv |
García Sanz, Ramón González Díaz, Marcos Vargas, M Chillón Santos, María del Carmen Balanzategui, A Barbón, M Flores, M T San Miguel Izquierdo, Jesús Fernando |
| author |
García Sanz, Ramón |
| author_facet |
García Sanz, Ramón González Díaz, Marcos Vargas, M Chillón Santos, María del Carmen Balanzategui, A Barbón, M Flores, M T San Miguel Izquierdo, Jesús Fernando |
| author_role |
author |
| author2 |
González Díaz, Marcos Vargas, M Chillón Santos, María del Carmen Balanzategui, A Barbón, M Flores, M T San Miguel Izquierdo, Jesús Fernando |
| author2_role |
author author author author author author author |
| dc.subject.none.fl_str_mv |
Myeloma p16 CDK4 Rarrangement Deletion Immunophenotyping Gene Deletion Adult Chromosome Deletion Humans Genes Prognosis Lymphoma Multiple Myeloma Mutation Gene Rearrangement Survival Analysis Cyclin-Dependent Kinase Inhibitor p16 3207.08 Hematología linfoma humanos mutación deleción génica mieloma múltiple inhibidor p16 de cinasas dependientes de ciclinas reordenamiento génico genes inmunofenotipificación pronóstico deleción cromosómica adulto análisis de supervivencia |
| topic |
Myeloma p16 CDK4 Rarrangement Deletion Immunophenotyping Gene Deletion Adult Chromosome Deletion Humans Genes Prognosis Lymphoma Multiple Myeloma Mutation Gene Rearrangement Survival Analysis Cyclin-Dependent Kinase Inhibitor p16 3207.08 Hematología linfoma humanos mutación deleción génica mieloma múltiple inhibidor p16 de cinasas dependientes de ciclinas reordenamiento génico genes inmunofenotipificación pronóstico deleción cromosómica adulto análisis de supervivencia |
| description |
Fue un artículo que incidió en el mal pronóstico de los pacientes con linfoma que tenían deleción del gen p16, también denominado Multitumor Supressor-1 (MTS-1) mieloma hiperdiploide, identificando un pequeño grupo de pacientes que debería recibir un tratamiento seleccionado. Estos resultados han sido confirmados luego con otras metodologías y el marcador pronóstico ha sido validado para otros propósitos. |
| publishDate |
1997 |
| dc.date.none.fl_str_mv |
1997 2024 2024 info |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10366/155212 |
| url |
http://hdl.handle.net/10366/155212 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
FIS-SS 94/1564 FIS-SS 96/1233 |
| dc.rights.none.fl_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 Internacional info:eu-repo/semantics/embargoedAccess |
| rights_invalid_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
| eu_rights_str_mv |
embargoedAccess |
| dc.publisher.none.fl_str_mv |
Springer Nature |
| publisher.none.fl_str_mv |
Springer Nature |
| dc.source.none.fl_str_mv |
reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca instname:Universidad de Salamanca (USAL) |
| instname_str |
Universidad de Salamanca (USAL) |
| reponame_str |
GREDOS. Repositorio Institucional de la Universidad de Salamanca |
| collection |
GREDOS. Repositorio Institucional de la Universidad de Salamanca |
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1869405760766607360 |
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15.300719 |