Prognostic and biological implications of genetic abnormalities in multiple myeloma undergoing autologous stem cell transplantation: t(4;14) is the most relevant adverse prognostic factor, whereas RB deletion as a unique abnormality is not associated with adverse prognosis

[EN]Fluorescence in situ hybridization (FISH) has become a powerful technique for prognostic assessment in multiple myeloma (MM). However, the existence of associations between cytogenetic abnormalities compels us to re-assess the value of each abnormality. A total of 260 patients with MM at the tim...

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Detalles Bibliográficos
Autores: Gutiérrez Gutiérrez, Norma Carmen, Castellanos, M. V., Martín, M. L., Mateos Manteca, María Victoria, Hernández, J. M., Fernández, M., Carrera, D., Rosiñol, Laura, Ribera, J. M., Ojanguren, J. M., Palomera, Luis, Gardella, S., Escoda, L., Hernández-Boluda, J. C., Bello, J. L., De la Rubia, Javier, Lahuerta, Juan José, San Miguel Izquierdo, Jesús Fernando
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2006
País:España
Institución:Universidad de Salamanca (USAL)
Repositorio:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/154372
Acceso en línea:http://hdl.handle.net/10366/154372
Access Level:acceso embargado
Palabra clave:Multiple myeloma
Genetic abnormalities
FISH
RB deletion
Multiple Myeloma
mieloma múltiple
Descripción
Sumario:[EN]Fluorescence in situ hybridization (FISH) has become a powerful technique for prognostic assessment in multiple myeloma (MM). However, the existence of associations between cytogenetic abnormalities compels us to re-assess the value of each abnormality. A total of 260 patients with MM at the time of diagnosis, enrolled in the GEM-2000 Spanish transplant protocol, have been analyzed by FISH in order to ascertain the independent influence on myeloma prognosis of IGH translocations, as well as RB and P53 deletions. Survival analyses showed that patients with t(4;14), RB or P53 deletions had a significantly shorter survival than patients without these abnormalities. However, patients with RB deletions without other abnormalities in FISH analysis, displayed a similar outcome to those patients without genetic changes by FISH (46 vs 54 months, P ¼ 0.3). In the multivariate analysis the presence of t(4;14), RB deletion associated with other abnormalities, age 460 years, high proportion of S-phase cells and advanced stage of the disease according to the International Staging System retained their independent prognostic influence. In summary, RB deletion as a sole abnormality does not lead to a shortening in the survival of MM patients, whereas t(4;14) confers the worst prognosis in MM patients treated with high-dose chemotherapy.

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